{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:49:59Z","timestamp":1771008599654,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T00:00:00Z","timestamp":1300924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Scope:<\/jats:bold> Previous results suggested that the effects of <jats:italic>Salvia fruticosa<\/jats:italic> tea (SFT) drinking on glucose regulation might be at the intestinal level. Here we aim to characterize the effects of SFT treatment and of its main phenolic constituent \u2013 rosmarinic acid (RA) \u2013 on the levels and localization of the intestinal Na+\/glucose cotransporter\u20101 (SGLT1), the facilitative glucose transporter 2 and glucagon\u2010like peptide\u20101 (GLP\u20101).<\/jats:p><jats:p><jats:bold>Methods and results:<\/jats:bold> Two models of SGLT1 induction in rats were used: through diabetes induction with streptozotocin (STZ) and through dietary carbohydrate manipulation. Drinking water was replaced with SFT or RA and blood parameters, liver glycogen and the levels of different proteins in enterocytes quantified. Two weeks of SFT treatment stabilized fasting blood glucose levels in STZ\u2010diabetic animals. The increase in SGLT1 localized to the enterocyte brush\u2010border membrane (BBM) induced by STZ treatment was significantly abrogated by treatment with SFT, without significant changes in total cellular transporter protein levels. No effects were observed on glucose transporter 2, Na<jats:sup>+<\/jats:sup>\/K<jats:sup>+<\/jats:sup>\u2010ATPase or glucagon\u2010like peptide\u20101 levels by SFT. Additionally, SFT and RA for 4 days significantly inhibited the carbohydrate\u2010induced adaptive increase of SGLT1 in BBM.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> SFT and RA modulate the trafficking of SGLT1 to the BBM and may contribute to the control of plasma glucose.<\/jats:p>","DOI":"10.1002\/mnfr.201000472","type":"journal-article","created":{"date-parts":[[2011,3,24]],"date-time":"2011-03-24T14:25:52Z","timestamp":1300976752000},"source":"Crossref","is-referenced-by-count":33,"title":["Rosmarinic acid, major phenolic constituent of Greek sage herbal tea, modulates rat intestinal SGLT1 levels with effects on blood glucose"],"prefix":"10.1002","volume":"55","author":[{"given":"Marisa F.","family":"Azevedo","sequence":"first","affiliation":[]},{"given":"Cristovao F.","family":"Lima","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Fernandes\u2010Ferreira","sequence":"additional","affiliation":[]},{"given":"Maria Judite","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Jonathan M.","family":"Wilson","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Pereira\u2010Wilson","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2011,3,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/414788a"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.12.3215"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.4.1277"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2005.05.001"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.08.059"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90030-H"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20061832"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.275.5.G879"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i29.4614"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1984.sp015165"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00310.2001"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117010"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2006.01746.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08905-5"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381517-0.00015-1"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102125.2010.03711.x"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.11.029"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9452(02)00052-3"},{"key":"e_1_2_6_20_2","unstructured":"Azevedo M. 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