{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T05:59:57Z","timestamp":1770011997031,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,16]],"date-time":"2016-06-16T00:00:00Z","timestamp":1466035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009991","name":"Cranberry Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009991","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Susanne Bunnenberg Heart Foundation"},{"name":"Medical Research Committee University of Dusseldorf","award":["9772574"],"award-info":[{"award-number":["9772574"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Nutrition Food Res"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Scope<\/jats:title><jats:p>Cranberries are rich in potentially bioactive (poly)phenols. The aim of this paper was to investigate whether cranberry juice intake can improve vascular function in healthy men in a dose\u2010 and time\u2010dependent manner, and to understand which of the circulating (poly)phenol metabolites correlate with vascular effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>A double\u2010blind randomized controlled crossover trial was conducted in ten healthy males. Flow\u2010mediated dilation (FMD), blood pressure, pulse wave velocity and augmentation index were investigated at baseline, 1, 2, 4, 6, and 8 h post\u2010consumption of cranberry juices containing 409, 787, 1238, 1534, and 1910 mg of total cranberry (poly)phenols (TP), and a control drink. Plasma (poly)phenol metabolites were analyzed by UPLC\u2010Q\u2010TOF MS using authentic standards. We observed dose\u2010dependent increases in FMD at 1, 2, 4, 6, and 8 h with a peak at 4 h and maximal effects with juice containing 1238 mg TP. A total of 60 metabolites were quantified in plasma after cranberry consumption. Twelve (poly)phenol metabolites significantly correlated with the increases in FMD, including ferulic and caffeic acid sulfates, quercetin\u20103\u2010<jats:italic>O<\/jats:italic>\u2010\u00df\u2010D\u2010glucuronide and a \u03b3\u2010valerolactone sulfate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>(Poly)phenols in cranberry juice can improve vascular function in healthy males and this is linked to the presence of specific newly identified plasma metabolites.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mnfr.201600250","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T09:22:45Z","timestamp":1464686565000},"page":"2130-2140","source":"Crossref","is-referenced-by-count":112,"title":["Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double\u2010blind, randomized, controlled, dose\u2010response, crossover study"],"prefix":"10.1002","volume":"60","author":[{"given":"Ana","family":"Rodriguez\u2010Mateos","sequence":"first","affiliation":[{"name":"Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty University D\u00fcsseldorf  D\u00fcsseldorf Germany"}]},{"given":"Rodrigo P","family":"Feliciano","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty University D\u00fcsseldorf  D\u00fcsseldorf Germany"}]},{"given":"Albert","family":"Boeres","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty University D\u00fcsseldorf  D\u00fcsseldorf Germany"}]},{"given":"Timon","family":"Weber","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty University D\u00fcsseldorf  D\u00fcsseldorf Germany"}]},{"given":"Claudia Nunes","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa Avenida da Rep\u00fablica  Oeiras Portugal"},{"name":"Instituto de Biologia Experimental e Tecnol\u00f3gica  Oeiras Portugal"}]},{"given":"M. Rita","family":"Ventura","sequence":"additional","affiliation":[{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Ant\u00f3nio Xavier, Universidade Nova de Lisboa Avenida da Rep\u00fablica  Oeiras Portugal"}]},{"given":"Christian","family":"Heiss","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty University D\u00fcsseldorf  D\u00fcsseldorf Germany"}]}],"member":"311","published-online":{"date-parts":[[2016,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf403757g"},{"key":"e_1_2_9_3_1","first-page":"35","volume-title":"Nutraceutical Beverages: Chemistry, Nutrition, and Health Effects, ACS Symposium Series 871","author":"Cunningham D. 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