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Isolated quercetin is also marketed as a dietary supplement, mostly as the free quercetin aglycone, and frequently in daily doses of up to 1000\u00a0mg\u00a0d<jats:sup>\u20131<\/jats:sup>exceeding usual dietary intake levels. The present review is dedicated to safety aspects of isolated quercetin used as single compound in dietary supplements. Among the numerous published human intervention studies, adverse effects following supplemental quercetin intake have been rarely reported and any such effects were mild in nature. Published adequate scientific data for safety assessment in regard to the long\u2010term use (&gt;12 weeks) of high supplemental quercetin doses (\u22651000\u00a0mg) are currently not available. Based on animal studies involving oral quercetin application some possible critical safety aspects could be identified such as the potential of quercetin to enhance nephrotoxic effects in the predamaged kidney or to promote tumor development especially in estrogen\u2010dependent cancer. Furthermore, animal and human studies with single time or short\u2010term supplemental quercetin application revealed interactions between quercetin and certain drugs leading to altered drug bioavailability. 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