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The inclusion of fresh fruits and vegetables rich in (poly)phenols has been encouraged by the World Health Organization (WHO) as part of the daily choices to ameliorate endothelial dysfunction and ease the socio\u2010economic burden of diabetes. Research in Food, Nutrition, and Cell Metabolism areas is revealing that the health benefits of (poly)phenol\u2010rich foods go beyond their antioxidant properties and are in fact key modulators of redox and glycaemia status, and inflammatory response contributing to improved endothelial function and vascular health in diabetes. Other beneficial aspects include appetite modulation, regulation of hydrolytic enzymes involved in sugar and lipid metabolism, and mediation of cell\u2013cell aggregation events. This work overviews the current knowledge on the biological properties of ingested (poly)phenols in cultured endothelial cells with emphasis on the circulating (poly)phenols, providing support to (poly)phenol\u2010rich diets as alternatives to drug\u2010based therapies in the prevention, treatment, and management of diabetes. A critical evaluation on the caveats and challenges involve in current experimental cell\u2010based designs and approaches adopted is also discussed.<\/jats:p>","DOI":"10.1002\/mnfr.202001130","type":"journal-article","created":{"date-parts":[[2021,5,29]],"date-time":"2021-05-29T15:55:11Z","timestamp":1622303711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["(Poly)phenol\u2010Rich Diets in the Management of Endothelial Dysfunction in Diabetes Mellitus: Biological Properties in Cultured Endothelial Cells"],"prefix":"10.1002","volume":"65","author":[{"given":"Sara","family":"Rocha","sequence":"first","affiliation":[{"name":"REQUIMTE\/LAQV Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  Rua do Campo Alegre Porto 4169\u2010007 Portugal"}]},{"given":"Olga","family":"Oskolkova","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry 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