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We evaluate the effects of denoising strategies on model fitting and parameter estimation when accounting for the dispersion of the label bolus through the vasculature in cerebrovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed multi\u2010delay ASL data from 17 cerebral small vessel disease patients (50\u2009\u00b1\u20099\u2009y) and 13 healthy controls (52\u2009\u00b1\u20098\u2009y), by fitting an extended kinetic model with or without bolus dispersion. We considered two denoising strategies: removal of structured noise sources by independent component analysis (ICA) of the control\u2010label image timeseries; and averaging the repetitions of the control\u2010label images prior to model fitting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Modeling bolus dispersion improved estimation precision and impacted parameter values, but these effects strongly depended on whether repetitions were averaged before model fitting. In general, repetition averaging improved model fitting but adversely affected parameter values, particularly CBF and aCBV near arterial locations in patients. This suggests that using all repetitions allows better noise estimation at the earlier delays. In contrast, ICA denoising improved model fitting and estimation precision while leaving parameter values unaffected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results support the use of ICA denoising to improve model fitting to multi\u2010delay ASL and suggest that using all control\u2010label repetitions improves the estimation of macrovascular signal contributions and hence perfusion quantification near arterial locations. This is important when modeling flow dispersion in cerebrovascular pathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29783","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T11:10:51Z","timestamp":1688037051000},"page":"1889-1904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Brain perfusion imaging by multi\u2010delay arterial spin labeling: Impact of modeling dispersion and interaction with denoising strategies and pathology"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-5535","authenticated-orcid":false,"given":"Sara","family":"Pires Monteiro","sequence":"first","affiliation":[{"name":"Department of Bioengineering Institute for Systems and Robotics\u00a0\u2013\u00a0Lisboa, Instituto Superior T\u00e9cnico\u00a0\u2013\u00a0Universidade de Lisboa  Lisbon 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