{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:59:33Z","timestamp":1792465173492,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Increases in adiposity and adverse changes in adipose distribution commonly occur in women during midlife and with the onset of menopause. This post hoc analysis assessed body weight changes with tirzepatide by reproductive stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Women participants from SURMOUNT\u20101, \u20103, and\u2009\u20104 randomized to tirzepatide (15\u2009mg or maximum tolerated dose) or placebo were retrospectively categorized as being in the pre\u2010, peri\u2010, or post\u2010menopause stages. Body weight and waist circumference changes, the proportion of participants achieving body weight\u2010reduction thresholds, and waist to height ratio (WHtR) category shift among those with baseline BMI\u2009&lt;\u200935 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were assessed at end of study treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In SURMOUNT\u20101, significantly greater body weight reductions from baseline were observed with tirzepatide versus placebo in women in the premenopause (26% vs. 2%), perimenopause (23% vs. 3%), and postmenopause stages (23% vs. 3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Greater waist circumference reductions were also observed with tirzepatide across the subgroups (22 vs. 4\u2009cm, 20 vs. 5\u2009cm, and 20 vs. 4\u2009cm, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Across the reproductive stage subgroups, 97% to 98% of participants achieved body weight reductions that were \u22655% with tirzepatide versus 29% to 33% with placebo. Furthermore, 30% to 52% of women among the reproductive stage subgroups who had baseline BMI\u2009&lt;\u200935 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      reached WHtR\u2009\u2264\u20090.49 (low central adiposity) with tirzepatide. Similar results were observed in SURMOUNT\u20103 and \u20104.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this post hoc analysis, tirzepatide treatment was associated with significant body weight, waist circumference, and WHtR reductions versus placebo in women living with obesity or overweight and without type 2 diabetes, irrespective of reproductive stage.<\/jats:p>\n                    <jats:p>\n                      <jats:boxed-text content-type=\"graphic\" position=\"anchor\">\n                        <jats:graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" mimetype=\"image\/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic\/oby24254-gra-0001-m.png\">\n                          <jats:alt-text>image<\/jats:alt-text>\n                        <\/jats:graphic>\n                      <\/jats:boxed-text>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/oby.24254","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T23:58:37Z","timestamp":1741823917000},"page":"851-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Body weight reduction in women treated with tirzepatide by reproductive stage: a post hoc analysis from the\n                    <scp>SURMOUNT<\/scp>\n                    program"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2955-8089","authenticated-orcid":false,"given":"Beverly G.","family":"Tchang","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Comprehensive Weight Control Center Weill Cornell Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea Ciudin","family":"Mihai","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Vall d'Hebron Institut de Recerca (VHIR; Vall d'Hebron Research Institute), Hospital Universitari Vall d'Hebron (Vall d'Hebron University Hospital) Vall d'Hebron Barcelona Campus Hospitalari (Vall d'Hebron Barcelona Hospital Campus)  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Stefanski","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis\u2010Emilio","family":"Garc\u00eda\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Mojdami","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Jouravskaya","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirel","family":"Gurbuz","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Taylor","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrisanthi A.","family":"Karanikas","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-0183","authenticated-orcid":false,"given":"Julia P.","family":"Dunn","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh299"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz273"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124556"},{"issue":"1","key":"e_1_2_11_5_1","first-page":"22","article-title":"Cardiometabolic risk in pre\u2010 and post\u2010menopausal women with special reference to insulin resistance: a cross\u2010sectional study","volume":"11","author":"Kirtikar U","year":"2020","journal-title":"J Midlife Health"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obpill.2023.100072"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35656"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2206038"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01200-X"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02597-w"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.24945"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-0243"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05682-4"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-022-01336-7"},{"key":"e_1_2_11_15_1","volume-title":"National Institute for Health and Care Excellence. 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