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They reveal diverse biological activities, especially antiviral and antitumor properties. From <jats:italic>Piper cubeba<\/jats:italic>, lignans of several classes can be isolated from the roots, rhizomes, stems, leaves, seeds, and fruits. Among its various chemical constituents, (\u2212)\u2010cubebin and (\u2212)\u2010hinokinin are found in significant quantities. Although they have been known for some time, during the last few decades their biological properties have been studied by several research groups. The cubebins have been identified as a lactol monomer and dimers as a mixture of diastereoisomers. Recently, their structural characterization and the synthesis of the possible structures have led to the correction of some earlier structural proposals. This review describes the more recent developments in the study of the medicinal attributes of cubebin and hinokinin extracted from <jats:italic>Piper cubeba<\/jats:italic> and the synthesis and biological testing of some analogues.<\/jats:p>","DOI":"10.1002\/open.201700182","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T07:08:48Z","timestamp":1519801728000},"page":"180-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Medicinal Attributes of Lignans Extracted from <i>Piper Cubeba<\/i>: Current Developments"],"prefix":"10.1002","volume":"7","author":[{"given":"Regiane","family":"Godoy\u2005de\u2005Lima","sequence":"first","affiliation":[{"name":"LAQV, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia Universidade Nova de Lisboa  2829-516 Caparica Portugal), Tel. 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