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SAHAquines are novel hybrid compounds that combine moieties of suberoylanilide hydroxamic acid (SAHA), an anticancer agent with weak antiplasmodial activity, and PQ, an antimalarial drug with low antiproliferative activity. The preparation of SAHAquines is simple, cheap, and high yielding. It includes the following steps: coupling reaction between primaquine and a dicarboxylic acid monoester, hydrolysis, a new coupling reaction with <jats:italic>O<\/jats:italic>\u2010protected hydroxylamine, and deprotection. SAHAquines <jats:bold>5\u2009a<\/jats:bold>\u2013<jats:bold>d<\/jats:bold> showed significant reduction in cell viability. Among the three human cancer cell lines (U2OS, HepG2, and MCF\u20107), the most responsive were the MCF\u20107 cells. The antibodies against acetylated histone H3K9\/H3K14 in MCF\u20107 cells revealed a significant enhancement following treatment with <jats:italic>N<\/jats:italic>\u2010hydroxy\u2010<jats:italic>N<\/jats:italic>\u2032\u2010{4\u2010[(6\u2010methoxyquinolin\u20108\u2010yl)amino]pentyl}pentanediamide (<jats:bold>5\u2009b<\/jats:bold>). Ethyl (2<jats:italic>E<\/jats:italic>)\u20103\u2010({4\u2010[(6\u2010methoxyquinolin\u20108\u2010yl)amino]pentyl}carbamoyl)prop\u20102\u2010enoate (<jats:bold>2\u2009b<\/jats:bold>) and SAHAquines were the most active compounds against both the hepatic and erythrocytic stages of <jats:italic>Plasmodium<\/jats:italic> parasites, some of them at sub\u2010micromolar concentrations. The results of our research suggest that SAHAquines are promising leads for new anticancer and antimalarial agents.<\/jats:p>","DOI":"10.1002\/open.201800117","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T14:27:51Z","timestamp":1534948071000},"page":"624-638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["SAHAquines, Novel Hybrids Based on SAHA and Primaquine Motifs, as Potential Cytostatic and Antiplasmodial Agents"],"prefix":"10.1002","volume":"7","author":[{"given":"Maja","family":"Beus","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry University of Zagreb  A. Kova\u010di\u0107a 1 10 000 Zagreb Croatia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1223-1116","authenticated-orcid":false,"given":"Zrinka","family":"Raji\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Biochemistry University of Zagreb  A. 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