{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:50:41Z","timestamp":1791359441314,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK127984"],"award-info":[{"award-number":["P30DK127984"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Obesity Science &amp; Practice"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) are effective treatments for obesity, but discontinuation is common due to cost, insurance coverage limitations, side effects, patient preference, and other factors. Weight regain often occurs rapidly after cessation, yet few evidence\u2010based strategies exist to support weight maintenance during this transition. This pilot randomized trial examined whether a digital wellness application or medically tailored meals (MTM) could mitigate weight gain during the first 4\u00a0months after GLP\u20101 cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this pilot randomized trial, adults with prior GLP\u20101\u2010induced weight loss were randomized to usual care, wellness application, or MTM at the time of GLP\u20101 cessation. Surveys assessed adherence and satisfaction (primary outcome) as well as exploratory outcomes, diet quality, and perceived health. Weight (exploratory) was measured monthly using validated Bluetooth scales.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a039) were randomized to control (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a014), digital wellness application (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a012), or MTM (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a013) and had a mean baseline BMI 31.4 (SD 6.3) kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Diet quality, perceived health, adherence, and satisfaction did not significantly differ by group, though some estimates suggested possible trends favoring the wellness application. Relative to control, both the wellness application and MTM groups had less total weight gain: Wellness application \u22127.16% (95% CI: \u221212.27, \u22122.04) and MTM \u22127.17% (\u221212.20, \u22122.14).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that structured support may attenuate early weight gain after GLP\u20101 cessation. Larger, more diverse trials with longer follow\u2010up and clinical outcomes are needed to confirm results and clarify mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/osp4.70194","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:01:59Z","timestamp":1791356519000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preventing Weight Regain After Glucagon\u2010Like Peptide\u20111 Therapy Discontinuation: A Pilot Randomized Controlled Trial"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0243-2830","authenticated-orcid":false,"given":"Kelseanna","family":"Hollis\u2010Hansen","sequence":"first","affiliation":[{"name":"Food is Medicine Institute Tufts University Friedman School of Nutrition Science and Policy  Boston Massachusetts 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