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A cross\u2010sectional study included a convenience sample of 110 caregivers who answered: the Burden Assessment Scale, the Depression Anxiety Stress Scales, the Social Support Satisfaction Scale, the Family Assessment Device, and the Short Form Health Survey. Multiple linear hierarchical regressions were performed to identify the variables that contributed to the burden and the physical and mental quality of life. Differences in burden as well as physical and mental quality of life were found, according to several caregivers\u2019 sociodemographic characteristics. Lower social support, more <jats:italic>distress<\/jats:italic>, and caregiver's perception of the impact of caring on the family dynamics contributed to burden. Lower <jats:italic>distress<\/jats:italic> and not having a chronic illness besides diabetes explained the physical quality of life whereas exercise and lower <jats:italic>distress<\/jats:italic> explained mental quality of life. To promote quality of life in caregivers and reduce the burden associated with caregiving, interventions should focus on social support, distress, and the practice of exercise.<\/jats:p>","DOI":"10.1002\/pchj.341","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T01:01:00Z","timestamp":1580432460000},"page":"707-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Burden and quality of life in caregivers of patients with amputated diabetic foot"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3545-0613","authenticated-orcid":false,"given":"Suely","family":"Costa","sequence":"first","affiliation":[{"name":"School of Psychology University of Minho  Braga Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-1756","authenticated-orcid":false,"given":"\u00c2ngela","family":"Leite","sequence":"additional","affiliation":[{"name":"School of Psychology University of Minho  Braga Portugal"}]},{"given":"Mariana","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"School of Psychology University of Minho  Braga Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5771-562X","authenticated-orcid":false,"given":"Susana","family":"Pedras","sequence":"additional","affiliation":[{"name":"School of Psychology University of Minho  Braga Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-2562","authenticated-orcid":false,"given":"M. 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