{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T05:02:52Z","timestamp":1698469372054},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,12,14]],"date-time":"2005-12-14T00:00:00Z","timestamp":1134518400000},"content-version":"vor","delay-in-days":3849,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Prenatal Diagnosis"],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal diagnosis in a pregnancy at risk for a juvenile B1 variant of GM<jats:sub>2<\/jats:sub>\u2010gangliosidosis was carried out. The biochemical study of the cultured amniocytes and the affected fetal brain is reported. The results obtained show that the sulphated artificial substrate can be used in the diagnosis of B1 variant, but not the neutral one. The accumulation of GM<jats:sub>2<\/jats:sub>\u2010ganglioside in the fetal brain of the B1 juvenile form and an infantile form of GM<jats:sub>2<\/jats:sub>\u2010gangliosidosis (0 variant) was compared.<\/jats:p>","DOI":"10.1002\/pd.1970150614","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T11:18:31Z","timestamp":1173007111000},"page":"585-588","source":"Crossref","is-referenced-by-count":5,"title":["Prenatal diagnosis of GM<sub>2<\/sub>\u2010gangliosidosis B1 variant"],"prefix":"10.1002","volume":"15","author":[{"given":"M.","family":"Lemos","sequence":"first","affiliation":[]},{"given":"R.","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"G.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"H.","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"L.","family":"Lopes","sequence":"additional","affiliation":[]},{"given":"M. C. 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