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In order to attain a comprehensive description of hCSC receptome and overcoming the inability demonstrated by other technologies applied in receptor identification, mainly due to the transmembrane nature, high hydrophobic character and relative low concentration of these proteins, we have exploited and improved a proteomics workflow. This approach was based on the enrichment of hCSC plasma membrane fraction and addition of prefractionation steps prior to MS analysis. More than 100 plasma membrane receptors were identified. The data reported herein constitute a valuable source of information to further understand cardiac stem cells activation mechanisms and the subsequent cardiac repair process. All MS data have been deposited in the ProteomeXchange with identifier PXD001117 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/proteomecentral.proteomexchange.org\/dataset\/PXD001117\">http:\/\/proteomecentral.proteomexchange.org\/dataset\/PXD001117<\/jats:ext-link>).<\/jats:p>","DOI":"10.1002\/pmic.201400318","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T06:37:46Z","timestamp":1418366266000},"page":"1332-1337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring analytical proteomics platforms toward the definition of human cardiac stem cells receptome"],"prefix":"10.1002","volume":"15","author":[{"given":"Patr\u00edcia","family":"Gomes\u2010Alves","sequence":"first","affiliation":[{"name":"iBET Instituto de Biologia Experimental e Tecnol\u00f3gica  Oeiras Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Universidade Nova de Lisboa  Oeiras Portugal"}]},{"given":"Margarida","family":"Serra","sequence":"additional","affiliation":[{"name":"iBET Instituto de Biologia Experimental e Tecnol\u00f3gica  Oeiras Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Universidade Nova de Lisboa  Oeiras Portugal"}]},{"given":"Catarina","family":"Brito","sequence":"additional","affiliation":[{"name":"iBET Instituto de Biologia Experimental e Tecnol\u00f3gica  Oeiras Portugal"},{"name":"Instituto de Tecnologia Qu\u00edmica e Biol\u00f3gica Universidade Nova de Lisboa  Oeiras Portugal"}]},{"given":"Luis","family":"R.\u2010Borlado","sequence":"additional","affiliation":[{"name":"Coretherapix  Tres\u2010Cantos, Madrid Spain"}]},{"given":"Juan A.","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Prote\u00f3mica Cardiovascular and Unidad de Prote\u00f3mica Centro Nacional de Investigaciones Cardiovasculares  Madrid Spain"}]},{"given":"Jes\u00fas","family":"V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Laboratorio de Prote\u00f3mica Cardiovascular and Unidad de Prote\u00f3mica Centro Nacional de Investigaciones Cardiovasculares  Madrid Spain"}]},{"given":"Manuel J. 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