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Despite the well\u2010established phenotypic alterations, the molecular mechanisms underlying exercise\u2010induced skeletal muscle remodeling are poorly characterized. Proteomics based on mass spectrometry have been successfully applied for the characterization of skeletal muscle proteome, representing a pivotal approach for the wide characterization of the molecular networks that lead to skeletal muscle remodeling. Nevertheless, few studies were performed to characterize the exercise\u2010induced proteome remodeling of skeletal muscle, with only six research papers focused on the cross\u2010talk between exercise and pathophysiological conditions. In order to add new insights on the impact of distinct exercise programs on skeletal muscle proteome, molecular network analysis was performed with bioinformatics tools. This analysis highlighted an exercise\u2010related proteome signature characterized by the up\u2010regulation of the capacity for ATP generation, oxygen delivery, antioxidant capacity and regulation of mitochondrial protein synthesis. Chronic endurance training up\u2010regulates the tricarboxylic acid cycle and oxidative phosphorylation system, whereas the release of calcium ion into cytosol and amino acid metabolism are the biological processes up\u2010regulated by a single bout of exercise. Other issues as exercise intensity, load, mode and regimen as well as muscle type also influence the exercise\u2010induced proteome signature. The comprehensive analysis of the molecular networks modulated by exercise training in health and disease, taking in consideration all these variables, might not only support the therapeutic effect of exercise but also highlight novel targets for the development of enhanced pharmacological strategies.<\/jats:p>","DOI":"10.1002\/pmic.201500382","type":"journal-article","created":{"date-parts":[[2015,12,3]],"date-time":"2015-12-03T04:28:37Z","timestamp":1449116917000},"page":"816-830","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Uncovering the exercise\u2010related proteome signature in skeletal muscle"],"prefix":"10.1002","volume":"16","author":[{"given":"Ana Isabel","family":"Padr\u00e3o","sequence":"first","affiliation":[{"name":"QOPNA Department of Chemistry University of Aveiro  Aveiro Portugal"},{"name":"CIAFEL Faculty of Sports University of Porto  Porto Portugal"}]},{"given":"Rita","family":"Ferreira","sequence":"additional","affiliation":[{"name":"QOPNA Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Francisco","family":"Amado","sequence":"additional","affiliation":[{"name":"QOPNA Department of Chemistry University of Aveiro  Aveiro Portugal"}]},{"given":"Rui","family":"Vitorino","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences and Institute for Biomedicine \u2013 iBiMED University of Aveiro  Aveiro Portugal"},{"name":"Department of Physiology and Cardiothoracic Surgery Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"Jos\u00e9 Alberto","family":"Duarte","sequence":"additional","affiliation":[{"name":"CIAFEL Faculty of Sports University of Porto  Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.051351"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000233795.39282.33"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000597"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1586\/epr.11.17"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02149"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02182"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1681.2002.03623.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.74.2.911"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00120.2002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.6.2250"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1992.72.2.484"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90428.2008"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2002.034850"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00247.2004"},{"key":"e_1_2_10_16_1","first-page":"395","article-title":"Growth of capillaries during long\u2010term activity in skeletal muscle","volume":"11","author":"Cotter M.","year":"1973","journal-title":"Biblioth. 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