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To make the most of these data, one of the first things that should be done is the functional annotation of the protein\u2010coding genes. But it used to be a slow and tedious step that can involve the characterization of thousands of sequences. Sma3s is an accurate computational tool for annotating proteins in an unattended way. Now, we have developed a completely new version, which includes functionalities that will be of utility for fundamental and applied science. Currently, the results provide functional categories such as biological processes, which become useful for both characterizing particular sequence datasets and comparing results from different projects. But one of the most important implemented innovations is that it has now low computational requirements, and the complete annotation of a simple proteome or transcriptome usually takes around 24 hours in a personal computer. Sma3s has been tested with a large amount of complete proteomes and transcriptomes, and it has demonstrated its potential in health science and other specific projects.<\/jats:p>","DOI":"10.1002\/pmic.201700071","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T17:58:12Z","timestamp":1495562292000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":92,"title":["Sma3s: A universal tool for easy functional annotation of proteomes and transcriptomes"],"prefix":"10.1002","volume":"17","author":[{"given":"Carlos S.","family":"Casimiro\u2010Soriguer","sequence":"first","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD\u2010CSIC\u2010JA) Universidad Pablo de Olavide  Sevilla Spain"}]},{"given":"Antonio","family":"Mu\u00f1oz\u2010M\u00e9rida","sequence":"additional","affiliation":[{"name":"CIBIO\u2010InBIO, Research Network in Biodiversity and Evolutionary Biology Universidade do Porto  Vair\u00e3o Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3343-2822","authenticated-orcid":false,"given":"Antonio J.","family":"P\u00e9rez\u2010Pulido","sequence":"additional","affiliation":[{"name":"Centro Andaluz de Biolog\u00eda del Desarrollo (CABD\u2010CSIC\u2010JA) Universidad Pablo de Olavide  Sevilla Spain"}]}],"member":"311","published-online":{"date-parts":[[2017,6,20]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37536"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2225-6"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000615"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1188800"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-41"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2340"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063754"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu851"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti610"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1883"},{"key":"e_1_2_4_12_1","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1471-2164-13-S7-S9","article-title":"FastAnnotator\u2014an efficient transcript annotation web tool","volume":"13","author":"Chen T.\u2010W.","year":"2012","journal-title":"BMC Genomics"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg566"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/dsu001"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-016-2411-1"},{"key":"e_1_2_4_16_1","first-page":"454","article-title":"Genomic survey of a hyperparasitic microsporidian Amphiamblys sp. 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