{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:24:51Z","timestamp":1760217891625,"version":"3.41.2"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/23\/B\/NZ7\/02350"],"award-info":[{"award-number":["2016\/23\/B\/NZ7\/02350"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Proteomics Clinical Apps"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Psoriatic skin lesions are associated with chronic inflammation related to immune cell activity. Therefore, the aim of this study is to compare changes in the proteome of psoriatic keratinocytes and lymphocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Design<\/jats:title><jats:p>A proteomics approach is used to analyze the expression of proteins in keratinocytes and lymphocytes from psoriatic patients and healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As a result 2119 proteins for keratinocytes and 1235 proteins for lymphocytes are identified. Psoriatic keratinocytes has 68 downregulated and 7 upregulated proteins and psoriatic lymphocytes has 106 downregulated and 67 upregulated proteins compared to healthy individuals. The list of downregulated proteins includes proteins involved in antioxidant homeostasis and, transcription regulation; upregulated proteins are involved in glycolytic processes and translation. These changes are accompanied by an increased level of 4\u2010Hydroxynonenal\u2010protein adducts; control cells are characterized by 4\u2010Hydroxynonenal\u2010Lysine adducts formed with structural and binding proteins, while in psoriatic cells 4\u2010Hydroxynonenal\u2010Lysine, 4\u2010Hydroxynonenal\u2010Histidine, and 4\u2010Hydroxynonenal\u2010Cysteine adducts with various molecular function proteins occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Clinical Relevance<\/jats:title><jats:p>This study highlights the changes in psoriatic keratinocytes and lymphocytes that can be directly involved in the development of psoriasis. In both cell types the most significant changes are associated with upregulation of phosphoglycerate mutase 1 and downregulation of thioredoxin reductase.<\/jats:p><\/jats:sec>","DOI":"10.1002\/prca.201800119","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T12:16:37Z","timestamp":1547640997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Proteomic Profile of Keratinocytes and Lymphocytes in Psoriatic Patients"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5397-7139","authenticated-orcid":false,"given":"Agnieszka","family":"G\u0119gotek","sequence":"first","affiliation":[{"name":"Department of Analytical Chemistry Medical University of Bialystok  15\u2010089 Bialystok Poland"}]},{"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[{"name":"Mass Spectrometry Center, QOPNA, Department of Chemistry University of Aveiro  3810\u2010193 Aveiro Portugal"}]},{"given":"Adam","family":"Wro\u0144ski","sequence":"additional","affiliation":[{"name":"Dermatological Specialized Center \u201cDERMAL\u201d NZOZ in Bialystok  15\u2010453 Bialystok Poland"}]},{"given":"Ewa","family":"Ambro\u017cewicz","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Medical University of Bialystok  15\u2010089 Bialystok Poland"}]},{"given":"El\u017cbieta","family":"Skrzydlewska","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Medical University of Bialystok  15\u2010089 Bialystok Poland"}]}],"member":"311","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_7_2_1","first-page":"194","volume":"198","author":"Jaiswal A. 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