{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:46:59Z","timestamp":1791830819705,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Prostate"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Homologous recombination repair (HRR) testing is increasingly relevant in prostate cancer because it identifies patients who may benefit from biomarker\u2010guided treatment strategies, including poly(ADP\u2010ribose) polymerase inhibitors (PARPi). However, real\u2010world implementation of HRR testing remains variable across countries and clinical settings, and the extent to which current testing pathways capture actionable alterations is not well defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ARON\u20103 is a multinational, multicentre, retrospective real\u2010world study of patients with prostate cancer. In this subanalysis, we assessed genomic testing uptake within the overall ARON\u20103 cohort and characterised HRR testing pathways and detected pathogenic alterations among patients with available genomic results. Genomic testing included germline, somatic tumour, and\/or circulating tumour DNA (ctDNA) assays performed in routine practice across participating centres. Multivariable logistic regression was used to identify clinicopathologic factors associated with undergoing genomic HRR testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 2,192 patients included in ARON\u20103, genomic testing results were available for 719 (33%). Among tested patients, 660 (92%) underwent germline testing and 610 (85%) somatic testing; 549 (77%) underwent both, whereas 109 (15%) had germline\u2010only and 61 (8%) somatic\u2010only testing. In multivariable analysis, metastatic castration\u2010resistant prostate cancer, high\u2010volume disease, and Gleason score &gt;\u20098 were independently associated with higher odds of testing, while age \u2265\u200970 years was associated with lower odds of testing. Overall, 238 tested patients (33%) harboured pathogenic HRR alterations, corresponding to 11% of the entire ARON\u20103 cohort. Somatic pathogenic alterations were more frequent than germline alterations.\n                      <jats:italic>BRCA2<\/jats:italic>\n                      was the most frequently altered gene, while\n                      <jats:italic>non\u2010BRCA1\/2<\/jats:italic>\n                      alterations were also detected, particularly in centres using broader multigene panels. Most centres relied on\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      \u2010focused assays, and the use of liquid biopsy remained limited.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This multinational real\u2010world analysis demonstrates substantial heterogeneity in HRR testing uptake and testing pathways across participating ARON\u20103 centres. Testing was more commonly performed in patients with more advanced disease features, suggesting that clinically relevant subgroups may still be differentially selected for genomic assessment. Broader and more standardised implementation of comprehensive HRR profiling may improve the identification of actionable alterations and strengthen precision medicine in prostate cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/pros.70269","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:10:53Z","timestamp":1791828653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World HRR Testing Pathways and Patterns of Detected Alterations in Prostate Cancer From the Multinational ARON\u20103 Study"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1199-7286","authenticated-orcid":false,"given":"Lorena","family":"Incorvaia","sequence":"first","affiliation":[{"name":"Department of Precision Medicine in Medical Surgical and Critical Care (Me.Pre.C.C.), Section of Medical Oncology, University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5169-3631","authenticated-orcid":false,"given":"Veronica","family":"Mollica","sequence":"additional","affiliation":[{"name":"Medical Oncology, IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4096-7385","authenticated-orcid":false,"given":"Ond\u0159ej","family":"Fiala","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapeutics Faculty of Medicine and University Hospital in Pilsen, Charles University Pilsen Czech Republic"},{"name":"Biomedical Center, Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic"},{"name":"ARON Research Foundation ETS Macerata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6774-7497","authenticated-orcid":false,"given":"Kazutoshi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Urology, Faculty of Medicine Kindai University Kindai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-9887","authenticated-orcid":false,"given":"Y\u00fcksel","family":"\u00dcr\u00fcn","sequence":"additional","affiliation":[{"name":"Medical Oncology, Ankara University Medical Faculty Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bohuslav","family":"Melichar","sequence":"additional","affiliation":[{"name":"Department of Oncology Faculty of Medicine and Dentistry, Palack\u00fd University Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4616-0598","authenticated-orcid":false,"given":"Javier","family":"Molina\u2010Cerrillo","sequence":"additional","affiliation":[{"name":"ARON Research Foundation ETS Macerata Italy"},{"name":"Medical Oncology Department Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-7236","authenticated-orcid":false,"given":"Teresa","family":"Alonso\u2010Gordoa","sequence":"additional","affiliation":[{"name":"Medical Oncology Department Hospital Universitario Ram\u00f3n y Cajal Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-2177","authenticated-orcid":false,"given":"Umberto","family":"Basso","sequence":"additional","affiliation":[{"name":"Oncology 1 Unit, Department of Oncology Istituto Oncologico Veneto IOV IRCCS Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Bourlon","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-7472","authenticated-orcid":false,"given":"Emmanuel","family":"Seront","sequence":"additional","affiliation":[{"name":"Institut Roi Albert II, Department of Medical Oncology Cliniques Universitaires Saint Luc Brussel Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7520-2908","authenticated-orcid":false,"given":"Ugo De","family":"Giorgi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) \u201cDino Amadori\u201d Meldola Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9 Juan","family":"Fita","sequence":"additional","affiliation":[{"name":"Medical Oncology, Fundaci\u00f3n Instituto Valenciano de Oncolog\u00eda Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Rescigno","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Centre for Cancer Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7936-5245","authenticated-orcid":false,"given":"Tarek","family":"Taha","sequence":"additional","affiliation":[{"name":"Royal Marsden NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando C.","family":"Maluf","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"},{"name":"Hospital Benefic\u00eancia Portuguesa S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4698-9195","authenticated-orcid":false,"given":"Alexandr","family":"Poprach","sequence":"additional","affiliation":[{"name":"Masaryk Memorial Cancer Institute, Brno, Czech Republic \u2010 Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-3754","authenticated-orcid":false,"given":"Simona De","family":"Summa","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Diagnostica Molecolare e Farmacogenetica, IRCCS Istituto Tumori Giovanni Paolo II Bari Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-994X","authenticated-orcid":false,"given":"Tomas","family":"Buchler","sequence":"additional","affiliation":[{"name":"Department of Oncology Second Faculty of Medicine, Charles University and University Hospital Motol and Homolka Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Galli","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit 2, Azienda Ospedaliera Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4126-0410","authenticated-orcid":false,"given":"Jindrich","family":"Kopecky","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology and Radiotherapy University Hospital Hradec Kralove Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Aurilio","sequence":"additional","affiliation":[{"name":"Division of Cancer Prevention and Genetics, IRCCS European Institute of Oncology Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5388-8910","authenticated-orcid":false,"given":"Jakub","family":"Kucharz","sequence":"additional","affiliation":[{"name":"Department of Uro\u2010Oncology Maria Sklodowska\u2010Curie National Research Institute of Oncology Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7934-1419","authenticated-orcid":false,"given":"Carlo","family":"Messina","sequence":"additional","affiliation":[{"name":"Oncology Unit, A.R.N.A.S. Civico Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-6175","authenticated-orcid":false,"given":"Gabriel Berlingieri","family":"Polho","sequence":"additional","affiliation":[{"name":"Hospital Sirio\u2010Liban\u00eas de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5814-2296","authenticated-orcid":false,"given":"Sarah","family":"Scagliarini","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology AORN \u201cA. Cardarelli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6010-7604","authenticated-orcid":false,"given":"Francesco","family":"Grillone","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit Presidio Ospedaliero Pugliese Ciaccio, Azienda Ospedaliera Universitaria \u201cRenato Dulbecco\u201d Catanzaro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Assed","family":"Bastos","sequence":"additional","affiliation":[{"name":"Hospital Sirio\u2010Liban\u00eas de S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Formisano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4363-6274","authenticated-orcid":false,"given":"Gian Paolo","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Territorial Oncology Operative Complex Unit \u2010 Casa Della Salute di Aprilia \u2010 ASL Latina Latina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Mosca","sequence":"additional","affiliation":[{"name":"Oncology Department Candiolo Cancer Institute Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5257-8678","authenticated-orcid":false,"given":"Alessandro","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Bed Management Presa in Carico, TDM, IRCCS Istituto Tumori \u201cGiovanni Paolo II\u201d Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5996-7262","authenticated-orcid":false,"given":"Aristotelis","family":"Bamias","sequence":"additional","affiliation":[{"name":"Propaedeutic Department of Internal Medicine, ATTIKON University Hospital, School of Medicine National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6621-8251","authenticated-orcid":false,"given":"Fernando Sabino Marques","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Latin American Cooperative Oncology Group \u2010 LACOG Porto Alegre Brazil"},{"name":"Hospital S\u00edrio\u2010Liban\u00eas Bras\u00edlia Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6729","authenticated-orcid":false,"given":"Andrey","family":"Soares","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein S\u00e3o Paulo Brazil"},{"name":"Latin American Cooperative Oncology Group \u2010 LACOG Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6476-6871","authenticated-orcid":false,"given":"Francesco","family":"Massari","sequence":"additional","affiliation":[{"name":"Medical Oncology, IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna Bologna Italy"},{"name":"Department of Medical and Surgical Sciences (DIMEC) University of Bologna Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7012-1754","authenticated-orcid":false,"given":"Andrew J.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Santoni","sequence":"additional","affiliation":[{"name":"ARON Research Foundation ETS Macerata Italy"},{"name":"Medical Oncology Unit, Macerata Hospital Macerata Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2023.102650"},{"issue":"3","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2022.100459","article-title":"Implementation of Preventive and Predictive BRCA Testing in Patients With Breast, Ovarian, Pancreatic, and Prostate Cancer: A Position Paper of Italian Scientific Societies","volume":"7","author":"Russo A.","year":"2022","journal-title":"ESMO Open"},{"issue":"9","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdz192","article-title":"A Decade of Clinical Development of PARP Inhibitors in Perspective","volume":"30","author":"Mateo J.","year":"2019","journal-title":"Annals of Oncology"},{"issue":"4","key":"e_1_2_13_5_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100235","article-title":"Impact of Deleterious Variants in Other Genes Beyond BRCA1\/2 Detected in Breast\/Ovarian and Pancreatic Cancer Patients by NGS\u2010Based Multi\u2010Gene Panel Testing: Looking Over the Hedge","volume":"6","author":"Bono M.","year":"2021","journal-title":"ESMO Open"},{"issue":"14","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1200\/JCO.23.02105","article-title":"Efficacy of Poly(ADP\u2010Ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene\u2010Mutated Metastatic Castration\u2010Resistant Prostate Cancer: A US Food and Drug Administration Pooled Analysis","volume":"42","author":"Fallah J.","year":"2024","journal-title":"Journal of Clinical Oncology"},{"issue":"5","key":"e_1_2_13_7_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMoa1603144","article-title":"Inherited DNA\u2010Repair Gene Mutations in Men With Metastatic Prostate Cancer","volume":"375","author":"Pritchard C. C.","year":"2016","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.383"},{"issue":"5","key":"e_1_2_13_9_1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.cell.2015.05.001","article-title":"Integrative Clinical Genomics of Advanced Prostate Cancer","volume":"161","author":"Robinson D.","year":"2015","journal-title":"Cell"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.025"},{"issue":"14","key":"e_1_2_13_11_1","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1200\/JCO.2012.43.1882","article-title":"Germline BRCA Mutations Are Associated with Higher Risk of Nodal Involvement, Distant Metastasis, and Poor Survival Outcomes in Prostate Cancer","volume":"31","author":"Castro E.","year":"2013","journal-title":"Journal of Clinical Oncology"},{"issue":"6","key":"e_1_2_13_12_1","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.eururo.2019.08.019","article-title":"Interim Results From the IMPACT Study: Evidence for Prostate\u2010Specific Antigen Screening in BRCA2 Mutation Carriers","volume":"76","author":"Page E. C.","year":"2019","journal-title":"European Urology"},{"issue":"2","key":"e_1_2_13_13_1","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/sj.bjc.6604132","article-title":"Prostate Cancer in Male BRCA1 and BRCA2 Mutation Carriers Has a More Aggressive Phenotype","volume":"98","author":"Mitra A.","year":"2008","journal-title":"British Journal of Cancer"},{"issue":"6","key":"e_1_2_13_14_1","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1200\/JCO.18.00358","article-title":"PROREPAIR\u2010B: A Prospective Cohort Study of the Impact of Germline DNA Repair Mutations on the Outcomes of Patients With Metastatic Castration\u2010Resistant Prostate Cancer","volume":"37","author":"Castro E.","year":"2019","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"e_1_2_13_15_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41698-022-00284-6","article-title":"The Tumor Mutational Landscape of BRCA2\u2010deficient Primary and Metastatic Prostate Cancer","volume":"6","author":"Kensler K. H.","year":"2022","journal-title":"npj Precision Oncology"},{"issue":"24","key":"e_1_2_13_16_1","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1056\/NEJMoa2022485","article-title":"Survival With Olaparib in Metastatic Castration\u2010Resistant Prostate Cancer","volume":"383","author":"Hussain M.","year":"2020","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"e_1_2_13_17_1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.eururo.2020.09.024","article-title":"Efficacy of PARP Inhibition in Metastatic Castration\u2010Resistant Prostate Cancer Is Very Different With Non\u2010BRCA DNA Repair Alterations: Reconstructing Prespecified Endpoints for Cohort B From the Phase 3 PROfound Trial of Olaparib","volume":"79","author":"Stopsack K. H.","year":"2021","journal-title":"European Urology"},{"issue":"4","key":"e_1_2_13_18_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41585-022-00680-4","article-title":"Prostate Cancer Risk, Screening and Management in Patients with Germline BRCA1\/2 Mutations","volume":"20","author":"Rajwa P.","year":"2023","journal-title":"Nature Reviews Urology"},{"issue":"11","key":"e_1_2_13_19_1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/humu.20880","article-title":"Sequence Variant Classification and Reporting: Recommendations for Improving the Interpretation of Cancer Susceptibility Genetic Test Results","volume":"29","author":"Plon S. E.","year":"2008","journal-title":"Human Mutation"},{"key":"e_1_2_13_20_1","doi-asserted-by":"crossref","first-page":"D980","DOI":"10.1093\/nar\/gkt1113","article-title":"ClinVar: Public Archive of Relationships among Sequence Variation and Human Phenotype","volume":"42","author":"Landrum M. J.","year":"2014","journal-title":"Nucleic Acids Research"},{"issue":"6","key":"e_1_2_13_21_1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/humu.22981","article-title":"HGVS Recommendations for the Description of Sequence Variants: 2016 Update","volume":"37","author":"Dunnen J. T.","year":"2016","journal-title":"Human Mutation"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911440"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200043"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01055-3"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01649"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506859"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.039"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2010.05.026"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2024.04.005"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.014"},{"key":"e_1_2_13_31_1","unstructured":"EAU Guidelines. Edn. presented at the EAU Annual Congress Paris.2024."},{"key":"e_1_2_13_32_1","unstructured":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae) Version 1. 2025 \u2014 December 4 2024."},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.09.017"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-024-05188-7"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1200\/GO.24.00072"}],"container-title":["The Prostate"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/pros.70269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/pros.70269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:10:57Z","timestamp":1791828657000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/pros.70269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,12]]},"references-count":34,"alternative-id":["10.1002\/pros.70269"],"URL":"https:\/\/doi.org\/10.1002\/pros.70269","archive":["Portico"],"relation":{},"ISSN":["0270-4137","1097-0045"],"issn-type":[{"value":"0270-4137","type":"print"},{"value":"1097-0045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,12]]},"assertion":[{"value":"2026-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"pros.70269"}}