{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:35:33Z","timestamp":1769027733111,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004907","name":"IHI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004907","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020098","name":"Innovative Health Initiative","doi-asserted-by":"publisher","award":["101034369"],"award-info":[{"award-number":["101034369"]}],"id":[{"id":"10.13039\/100020098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A better understanding of patients' adherence to treatment is a prerequisite to maximize the benefit of healthcare provision for patients, reduce treatment costs, and is a key factor in a variety of subsequent health outcomes. We aim to understand the state of the art of scientific evidence about which factors influence patients' adherence to treatment. A systematic literature review was conducted using PRISMA guidelines in five separate electronic databases of scientific publications: PubMed, PsycINFO (ProQuest), Cochrane library (Ovid), Google Scholar, and Web of Science. The search focused on literature reporting the significance of factors in adherence to treatment between 2011 and 2021, including only experimental studies (e.g., randomized controlled trials [RCT], clinical trials, etc.). We included 47 experimental studies. The results of the systematic review (SR) are grouped according to predetermined categories of the World Health Organization (WHO): socioeconomic, treatment, condition, personal, and healthcare\u2010related factors. This review gives an actual overview of evidence\u2010based studies on adherence and analyzed the significance of factors defined by the WHO classification. By showing the strength of certain factors in several independent studies and concomitantly uncovering gaps in research, these insights could serve as a basis for the design of future adherence studies and models.<\/jats:p>","DOI":"10.1002\/prp2.1166","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T08:38:40Z","timestamp":1704962320000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A systematic review on experimental studies about patient adherence to treatment"],"prefix":"10.1002","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7602-3792","authenticated-orcid":false,"given":"Frans","family":"Folkvord","sequence":"first","affiliation":[{"name":"PredictBy  Barcelona Spain"},{"name":"Tilburg Center for Cognition and Communication (TiCC), Department of Communication and Cognition Tilburg University  Tilburg The Netherlands"}]},{"given":"Ana Roca\u2010Umbert","family":"W\u00fcrth","sequence":"additional","affiliation":[{"name":"PredictBy  Barcelona Spain"}]},{"given":"Karlijn","family":"van Houten","sequence":"additional","affiliation":[{"name":"PredictBy  Barcelona Spain"}]},{"given":"Aad R.","family":"Liefveld","sequence":"additional","affiliation":[{"name":"Link2Trials  Hilversum The Netherlands"}]},{"given":"Jim Ingebretsen","family":"Carlson","sequence":"additional","affiliation":[{"name":"PredictBy  Barcelona Spain"}]},{"given":"Nadine","family":"Bol","sequence":"additional","affiliation":[{"name":"Tilburg Center for Cognition and Communication (TiCC), Department of Communication and Cognition Tilburg University  Tilburg The Netherlands"}]},{"given":"Emiel","family":"Krahmer","sequence":"additional","affiliation":[{"name":"Tilburg Center for Cognition and Communication (TiCC), Department of Communication and Cognition Tilburg University  Tilburg The Netherlands"}]},{"given":"Gwenn","family":"Beets","sequence":"additional","affiliation":[{"name":"Tilburg Center for Cognition and Communication (TiCC), Department of Communication and Cognition Tilburg University  Tilburg The Netherlands"}]},{"given":"Rachel Drbohlav","family":"Ollerton","sequence":"additional","affiliation":[{"name":"Tilburg Center for Cognition and Communication (TiCC), Department of Communication and Cognition Tilburg University  Tilburg The Netherlands"}]},{"given":"Eva","family":"Turk","sequence":"additional","affiliation":[{"name":"Institute for Health and Society University of Oslo  Oslo Norway"}]},{"given":"Harald","family":"Hrubos\u2010Str\u00f8m","sequence":"additional","affiliation":[{"name":"Akershus University Hospital  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}]},{"given":"Hamza","family":"Nahoui","sequence":"additional","affiliation":[{"name":"Akershus University Hospital  L\u00f8renskog Norway"}]},{"given":"Gunnar","family":"Einvik","sequence":"additional","affiliation":[{"name":"Akershus University Hospital  L\u00f8renskog Norway"}]},{"given":"Henrik","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Akershus University Hospital  L\u00f8renskog Norway"}]},{"given":"Anne","family":"Moen","sequence":"additional","affiliation":[{"name":"Institute for Health and Society University of Oslo  Oslo Norway"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2582-0203","authenticated-orcid":false,"given":"Jaime","family":"Barrio\u2010Cortes","sequence":"additional","affiliation":[{"name":"Foundation for Biosanitary Research and Innovation in Primary Care  Madrid Spain"},{"name":"Research Unit, Primary Healthcare Management, Madrid Health Service  Madrid Spain"},{"name":"University Camilo Jos\u00e9 Cela  Madrid Spain"}]},{"given":"Beatriz","family":"Merino\u2010Barbancho","sequence":"additional","affiliation":[{"name":"Universidad Polit\u00e9cnica de Madrid, Life Supporting Technologies Research Group  Madrid Spain"}]},{"given":"Pe\u00f1a","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Universidad Polit\u00e9cnica de Madrid, Life Supporting Technologies Research Group  Madrid Spain"}]},{"given":"Giuseppe","family":"Fico","sequence":"additional","affiliation":[{"name":"Universidad Polit\u00e9cnica de Madrid, Life Supporting Technologies Research Group  Madrid Spain"}]},{"given":"Lu\u00eds","family":"Mid\u00e3o","sequence":"additional","affiliation":[{"name":"Associate Laboratory i4HB \u2013 Institute for Health and Bioeconomy, UCIBIO \u2013 Applied Molecular Biosciences Unit, Porto4Ageing \u2013 Competence Centre on Active and Healthy Ageing, Faculty of Pharmacy of the University of Porto  Porto Portugal"}]},{"given":"Rute","family":"Sampaio","sequence":"additional","affiliation":[{"name":"CINTESIS@RISE, Department of Biomedicine Faculty of Medicine of the University of Porto  Porto Portugal"}]},{"given":"Jo\u00e3o A.","family":"Fonseca","sequence":"additional","affiliation":[{"name":"MEDIDA, Medicina, EDuca\u00e7\u00e3o, I&amp;D e Avalia\u00e7\u00e3o Lda  Portugal"},{"name":"MEDCIDS, Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine University of Porto  Porto Portugal"}]},{"given":"Katja","family":"Geipel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Heinrich\u2010Heine\u2010University  D\u00fcsseldorf Germany"}]},{"given":"Kathrin","family":"Scheckenbach","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Heinrich\u2010Heine\u2010University  D\u00fcsseldorf Germany"}]},{"given":"Laura E.","family":"de Ruiter","sequence":"additional","affiliation":[{"name":"Behavioral Science Consortium, Astellas Pharma  Northbrook Illinois USA"}]},{"given":"Francisco","family":"Lupi\u00e1\u00f1ez\u2010Villanueva","sequence":"additional","affiliation":[{"name":"PredictBy  Barcelona Spain"},{"name":"Universidad Oberta de Catalunya, Information and Communication Sciences  Barcelona Spain"}]}],"member":"311","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016982"},{"key":"e_1_2_14_3_1","first-page":"189","article-title":"The challenge of patient adherence","volume":"1","author":"Martin LR","year":"2005","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_14_4_1","doi-asserted-by":"crossref","unstructured":"OECD & European Union.Health at a Glance: Europe 2018: State of Health in the EU Cycle.2018. doi:10.1787\/health_glance_eur-2018-en","DOI":"10.1787\/health_glance_eur-2018-en"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlr.0000114908.90348.f9"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0090-2021"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12582"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(99)00468-2"},{"key":"e_1_2_14_9_1","volume-title":"Interventions for the Treatment of Obstructive Sleep Apnea in Adults: a Health Technology Assessment","author":"Kim J","year":"2017"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41562-020-0884-z"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42256-020-00287-7"},{"key":"e_1_2_14_12_1","unstructured":"Sabat\u00e9E.Adherence to Long\u2010Term Therapies. Vol30.World Health Organization;2003. Accessed November 11 2022.https:\/\/apps.who.int\/iris\/handle\/10665\/42682"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1474515114537024"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-016-3858-0"},{"key":"e_1_2_14_15_1","doi-asserted-by":"crossref","unstructured":"SiregarFA AndayaniLS.Analysis social determinant of adherence to treatment in pulmonary tuberculosis patients in Medan City. Proceedings of the International Conference of Science Technology Engineering Environmental and Ramification Research (942\u2010945)2020. doi:10.5220\/0010104709420945","DOI":"10.5220\/0010104709420945"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2015.21.6.479"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-012-2195-1"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-018-4702-7"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105395"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.2446"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-016-3492-0"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcn.0000000000000702"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.68.8895"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155147"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18084308"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399811666150722130232"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-019-00896-2"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14610"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-020-05224-y"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2018\/e325"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.12140"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijpp.12598"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.01.006"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-015-0471-5"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.05.010"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcn.0000000000000631"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2018.04.024"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.30"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12965"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.04.045"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.31128\/AFP-10-17-4351"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.7399\/fh.11325"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-014546"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mib.0000437500.60546.2a"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0b013e3182725532"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hct121"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.2012.01411.x"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-014-3072-x"},{"issue":"12","key":"e_1_2_14_49_1","first-page":"e547","article-title":"Improving medication understanding among Latinos through illustrated medication lists","volume":"20","author":"Mohan A","year":"2014","journal-title":"Am J Manag Care"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2012.02571.x"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-014-0958-x"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2013.19.5.396"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.1166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T09:43:30Z","timestamp":1708076610000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.1166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/prp2.1166"],"URL":"https:\/\/doi.org\/10.1002\/prp2.1166","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]},"assertion":[{"value":"2023-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1166"}}