{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:35:03Z","timestamp":1790033703124,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22\u201015\u201000064"],"award-info":[{"award-number":["22\u201015\u201000064"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Quercetin is a bioactive flavonoid, but the effect of it on cardiometabolic factors has remained uncertain and previous findings from meta\u2010analyses have been controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To provide an overview of the effects of Quercetin on cardiometabolic factors based on meta\u2010analyses of randomized controlled trials (RCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>MEDLINE, SciVerse Scopus, and Clarivate Analytics Web of Science databases were searched to identify eligible publications. As part of the umbrella review, we summarized pooled estimates, 95% CIs, heterogeneity, and publication bias. A GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach was used to rate the certainty of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Five meta\u2010analyses including 18 eligible RCTs plus 5 RCTs that were not included in previous meta\u2010analyses were found. The results indicated Quercetin does not affect diastolic blood pressure (DBP), lipid profile, inflammation, anthropometric indices, fasting plasma glucose (FBG), and homeostatic model assessment for insulin resistance (HOMA\u2010IR). However, Quercetin supplementation could significantly reduce systolic blood pressure (SBP) (weighted mean difference (WMD): \u22121.9, 95% CI\u2009=\u2009\u22123.2 to \u22120.6, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200988.3%) and insulin level (WMD: \u22121.07, 95% CI\u2009=\u2009\u22121.9 to \u22120.1, I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200975.0%). The certainty of evidence ranged from very low to moderate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quercetin supplementation has reducing effects on SBP and insulin levels but not other cardiometabolic parameters. More high\u2010quality trials with longer follow\u2010up durations may be required to obtain a more robust conclusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ptr.7971","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:24:44Z","timestamp":1693538684000},"page":"5080-5091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The effects of Quercetin supplementation on cardiometabolic outcomes: An umbrella review of meta\u2010analyses of randomized controlled trials"],"prefix":"10.1002","volume":"37","author":[{"given":"Seyyed Mostafa","family":"Arabi","sequence":"first","affiliation":[{"name":"Noncommunicable Diseases Research Center Neyshabur University of Medical Sciences  Neyshabur Iran"},{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Shahraki Jazinaki","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahla","family":"Chambari","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Neyshabur University of Medical Sciences  Neyshabur Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila Sadat","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Noncommunicable Diseases Research Center Neyshabur University of Medical Sciences  Neyshabur Iran"},{"name":"Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Maleki","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Medicine, Zahedan University of Medical Sciences  Zahedan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasily N.","family":"Sukhorukov","sequence":"additional","affiliation":[{"name":"Institute for Atherosclerosis Research  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Applied Biomedical Research Center Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Biotechnology School of Pharmacy, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.06.077"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.955"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102288"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666160909153707"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/91201079"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190829153552"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-2863(02)00208-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_10_13_1","volume-title":"& Welch","author":"Higgins J. 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