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The hit compounds were confirmed by pharmacological evaluation at the 5\u2010HT<jats:sub>2A<\/jats:sub>receptor and complemented by the selection of other representatives of the same chemical family within our chemical library. A promising scaffold of 6\u2010(pyperazin\u20101\u2010yl) purine was identified, and the binding mode is illustrated with an automated docking exploration on a homology built model of the 5\u2010HT<jats:sub>2A<\/jats:sub>receptor. 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