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In particularly, Cramer's steroid data set has become a benchmark for the assessment of novel QSAR methods. This data set has been used by several researchers using 3D\u2010QSAR approaches. Therefore, it is selected by us for the shake of comparability. In addition, to evaluate the effectiveness of this novel approach in drug design, we model the angiotensin\u2010converting enzyme inhibitory activity of perindoprilate's \u03c3\u2010stereoisomers combinatorial library, as well as codify information related to a pharmacological property, highly dependent on the molecular symmetry, of a set of seven pairs of chiral<jats:italic>N<\/jats:italic>\u2010alkylated 3\u2010(3\u2010hydroxyphenyl)\u2010piperidines, which bind \u03c3\u2010receptors. The validation of this method is achieved by comparison with earlier publications applied to the same data sets. The nonstochastic and stochastic bond\u2010based 3D\u2010chiral quadratic indices appear to provide a rather interesting alternative to other more common 3D\u2010QSAR descriptors.<\/jats:p>","DOI":"10.1002\/qsar.200960085","type":"journal-article","created":{"date-parts":[[2009,12,14]],"date-time":"2009-12-14T18:30:35Z","timestamp":1260815435000},"page":"1465-1477","source":"Crossref","is-referenced-by-count":13,"title":["Applications of Bond\u2010Based 3D\u2010Chiral Quadratic Indices in QSAR Studies Related to Central Chirality Codification"],"prefix":"10.1002","volume":"28","author":[{"given":"Juan\u2005A.","family":"Castillo\u2010Garit","sequence":"first","affiliation":[]},{"given":"Yovani","family":"Marrero\u2010Ponce","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Torrens","sequence":"additional","affiliation":[]},{"given":"Ramon","family":"Garc\u00eda\u2010Domenech","sequence":"additional","affiliation":[]},{"given":"J.\u2005Enrique","family":"Rodr\u00edguez\u2010Borges","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2009,12,22]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci000082a"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00401-7"},{"key":"e_1_2_1_3_2","author":"Potapov V. 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