{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:22:10Z","timestamp":1777476130902,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistrySelect"],"published-print":{"date-parts":[[2016,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Oxidative stress is involved in several parasitic diseases such as Chagas. Agents able to selectively modulate biochemical processes involved in the disease represent promising multifunctional agents for the delay or abolishment of the progression of this pathology. In the current work, differently substituted 3\u2010carboxamidocoumarins exerting both antioxidant and trypanocidal activities are described. Among the compounds synthesized, compound\n                    <jats:bold>3<\/jats:bold>\n                    (\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(4\u2010hydroxyphenyl)coumarin\u20103\u2010carboxamide) showed the most interesting antioxidant profile, presenting 53.2\u2009% superoxide radical scavenging and the highest ORAC\u2010FL value (ORAC\u2010FL=1.87) of the series. In the trypanocidal study, compounds\n                    <jats:bold>9<\/jats:bold>\n                    (\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(quinolin\u20106\u2010yl)coumarin\u20103\u2010carboxamide) and\n                    <jats:bold>10<\/jats:bold>\n                    (\n                    <jats:italic>N<\/jats:italic>\n                    \u2010(quinolin\u20103\u2010yl)coumarin\u20103\u2010carboxamide) presented high activity in epimastigote stage and low activity in trypomastigote stage, as well as low cytotoxic effects. Additionally, these compounds decreased mitochondrial transmembrane potential in epimastigote Dm28c. Based on these results, compounds\n                    <jats:bold>9<\/jats:bold>\n                    and\n                    <jats:bold>10<\/jats:bold>\n                    proved to be good candidates for further studies. Interestingly, the current study revealed that small structural changes in this scaffold allow modulating both activities, suggesting that these molecules present the desirable properties for the development of promising classes of antichagasic compounds.\n                  <\/jats:p>","DOI":"10.1002\/slct.201601336","type":"journal-article","created":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T14:00:54Z","timestamp":1475244054000},"page":"4957-4964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Antioxidant and Antitrypanosomal Properties of a Selected Series of Synthetic 3\u2010Carboxamidocoumarins"],"prefix":"10.1002","volume":"1","author":[{"given":"Andrea","family":"Mu\u00f1oz","sequence":"first","affiliation":[{"name":"Free Radical and Antioxidants Laboratory, Inorganic and Analytical Department Faculty of Chemical and Pharmaceutical Sciences, University of Chile  Sergio Livingstone Polhammer 1007, Independencia Santiago Chile"}]},{"given":"Andr\u00e9","family":"Fonseca","sequence":"additional","affiliation":[{"name":"CIQUP\/Departament of Chemistry and Biochemistry, Faculty of Sciences University of Porto  4169-007 Porto Portugal"},{"name":"Department of Organic Chemistry, Faculty of Pharmacy University of Santiago de Compostela  15806 Santiago de Compostela Spain"}]},{"given":"Maria J.","family":"Matos","sequence":"additional","affiliation":[{"name":"CIQUP\/Departament of Chemistry and Biochemistry, Faculty of Sciences University of Porto  4169-007 Porto Portugal"},{"name":"Department of Organic Chemistry, Faculty of Pharmacy University of Santiago de Compostela  15806 Santiago de Compostela Spain"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy University of Santiago de Compostela  15806 Santiago de Compostela Spain"}]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Pharmacy University of Santiago de Compostela  15806 Santiago de Compostela Spain"}]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Departament of Chemistry and Biochemistry, Faculty of Sciences University of Porto  4169-007 Porto Portugal"}]},{"given":"Roberto","family":"Figueroa","sequence":"additional","affiliation":[{"name":"Free Radical and Antioxidants Laboratory, Inorganic and Analytical Department Faculty of Chemical and Pharmaceutical Sciences, University of Chile  Sergio Livingstone Polhammer 1007, Independencia Santiago Chile"}]},{"given":"Claudio","family":"Olea\u2005Azar","sequence":"additional","affiliation":[{"name":"Free Radical and Antioxidants Laboratory, Inorganic and Analytical Department Faculty of Chemical and Pharmaceutical Sciences, University of Chile  Sergio Livingstone Polhammer 1007, Independencia Santiago Chile"}]}],"member":"311","published-online":{"date-parts":[[2016,9,30]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(00)00570-0"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.04.015"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2890"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2012.07.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150220113155"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.07.013"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.03.038"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573406412666160107111809"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.13.147"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2012.03.002"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.046"},{"key":"e_1_2_6_12_1","first-page":"297","volume-title":"Studies in Natural Products Chemistry, Vol. 39","author":"Muschietti L. 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