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The present approach shows the significant outcomes such as yield up to 94%, catalyst\u2010free reaction, easy workup procedure and shorter period of reaction time. In this work we also highlighted the comparison of the yields obtained under both neat and solvent media as well. The anti\u2010proliferative activity of all newly synthesized compounds has been assessed against six human solid tumor cell lines. Seven compounds show good activity against single cell line whereas, compounds having a pyridine scaffold showed significant anti\u2010proliferative activity.<\/jats:p>","DOI":"10.1002\/slct.201802537","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T10:49:36Z","timestamp":1542624576000},"page":"12163-12168","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Anti\u2010Proliferative 1,4\u2010Dihydropyridine and Pyridine Derivatives Synthesized through a Catalyst\u2010Free, One\u2010Pot Multi\u2010Component Reaction"],"prefix":"10.1002","volume":"3","author":[{"given":"Mayank G.","family":"Sharma","sequence":"first","affiliation":[{"name":"Sardar Patel University Department of Chemistry University Campus  Vallabh Vidyanagr- 388 120 Gujarat India"}]},{"given":"Ruturajsinh M.","family":"Vala","sequence":"additional","affiliation":[{"name":"Sardar Patel University Department of Chemistry University Campus  Vallabh Vidyanagr- 388 120 Gujarat India"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4740-7329","authenticated-orcid":false,"given":"Divyang M.","family":"Patel","sequence":"additional","affiliation":[{"name":"Sardar Patel University Department of Chemistry University Campus  Vallabh Vidyanagr- 388 120 Gujarat India"}]},{"given":"Irene","family":"Lagunes","sequence":"additional","affiliation":[{"name":"BioLab Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez CIBICAN Universidad de La Laguna  Avda. Astrof\u00edsico Francisco S\u00e1nchez 2 38206 La Laguna Spain."}]},{"given":"Miguel X.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"BioLab Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez CIBICAN Universidad de La Laguna  Avda. Astrof\u00edsico Francisco S\u00e1nchez 2 38206 La Laguna Spain."}]},{"given":"Jos\u00e9 M.","family":"Padr\u00f3n","sequence":"additional","affiliation":[{"name":"Sardar Patel University Department of Chemistry University Campus  Vallabh Vidyanagr- 388 120 Gujarat India"},{"name":"BioLab Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez CIBICAN Universidad de La Laguna  Avda. Astrof\u00edsico Francisco S\u00e1nchez 2 38206 La Laguna Spain."},{"name":"Present address: BioLab Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez, CIBICAN, Universidad de La Laguna  Avda. 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