{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T16:41:28Z","timestamp":1771692088838,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T00:00:00Z","timestamp":1547510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistrySelect"],"published-print":{"date-parts":[[2019,1,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, presenting the most devastating consequences on human health and life quality. Coumarin\u2010quinoline hybrids were synthesized following a very efficient and versatile strategy. Small structural variations contributed to dual acetyl\/butyrylcholinesterases (AChE\/BuChE) activity or selectivity towards one of these enzymes. In addition, some of the studied compounds are interesting iron chelators, presenting a tendency to be neuroprotective. Moreover, the compounds are not cytotoxic for SH\u2010SY5Y neuroblastoma cells. Compound\n                    <jats:bold>\n                      9\n                      <jats:sub>c<\/jats:sub>\n                    <\/jats:bold>\n                    proved to be the most interesting compound of the studied series. This compound is selective against AChE and proved to be an excellent iron chelating agent (iron chelation at 100\u2005\u03bcM=72.87%). Molecular docking studies were performed to establish the nature of the interaction between the studied compounds and the binding pockets, leading to a rationalization of structure\u2013activity relationships. Compound\n                    <jats:bold>\n                      9\n                      <jats:sub>c<\/jats:sub>\n                    <\/jats:bold>\n                    forms a well\u2010defined \u03c0\u2010stacking interaction with Phe330 and interacts with Tyr121 residue via a hydrogen bond, while the inactive compounds cannot establish these interactions. Important preliminary results against different targets, as well as some structure\u2013activity relationships, were concluded from the experimental results.\n                  <\/jats:p>","DOI":"10.1002\/slct.201803222","type":"journal-article","created":{"date-parts":[[2019,1,15]],"date-time":"2019-01-15T08:37:12Z","timestamp":1547541432000},"page":"551-558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Novel Coumarin\u2010Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease"],"prefix":"10.1002","volume":"4","author":[{"given":"Yorley","family":"Duarte","sequence":"first","affiliation":[{"name":"Laboratorio de S\u00edntesis Org\u00e1nica y Actividad Biol\u00f3gica Instituto de Qu\u00edmica de Recursos Naturales Universidad de Talca, Casilla 747  3460000 Talca Chile"},{"name":"Center for Bioinformatics and Integrative Biology Facultad de Ciencias de la Vida Universidad Andr\u00e9s Bello  Santiago 8370146 Chile"}]},{"given":"Andr\u00e9","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  15782 Santiago de Compostela Espa\u00f1a"}]},{"given":"Margarita","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Laboratorio de S\u00edntesis Org\u00e1nica y Actividad Biol\u00f3gica Instituto de Qu\u00edmica de Recursos Naturales Universidad de Talca, Casilla 747  3460000 Talca Chile"}]},{"given":"Francisco","family":"Adasme\u2010Carre\u00f1o","sequence":"additional","affiliation":[{"name":"Centro de Bioinform\u00e1tica y Simulaci\u00f3n Molecular Universidad de Talca, Casilla 721  3460000 Talca Chile"}]},{"given":"Camila","family":"Mu\u00f1oz\u2010Gutierrez","sequence":"additional","affiliation":[{"name":"Centro de Bioinform\u00e1tica y Simulaci\u00f3n Molecular Universidad de Talca, Casilla 721  3460000 Talca Chile"}]},{"given":"Jans","family":"Alzate\u2010Morales","sequence":"additional","affiliation":[{"name":"Centro de Bioinform\u00e1tica y Simulaci\u00f3n Molecular Universidad de Talca, Casilla 721  3460000 Talca Chile"}]},{"given":"Lourdes","family":"Santana","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  15782 Santiago de Compostela Espa\u00f1a"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  15782 Santiago de Compostela Espa\u00f1a"},{"name":"Instituto de Ciencias Qu\u00edmicas Aplicadas Universidad Aut\u00f3noma de Chile  7500912 Santiago Chile"}]},{"given":"Roc\u00edo","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology Faculty of Pharmacy Universidad de Valpara\u00edso  Gran Breta\u00f1a 1093 2360102 Valpara\u00edso Chile"},{"name":"Centro de Investigaci\u00f3n Farmacopea Chilena (CIFAR), Valpara\u00edso  Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-8299","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Matos","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultad de Farmacia Universidade de Santiago de Compostela  15782 Santiago de Compostela Espa\u00f1a"}]}],"member":"311","published-online":{"date-parts":[[2019,1,15]]},"reference":[{"key":"e_1_2_6_1_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.66.2.137"},{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02940"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1132814"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0022-3565(24)39312-7","volume":"293","author":"Xie W. 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