{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:19:38Z","timestamp":1773350378072,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistrySelect"],"published-print":{"date-parts":[[2020,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This work reports the half maximal inhibitory concentrations, IC\n                    <jats:sub>50<\/jats:sub>\n                    , for conventional anti\u2010cancer drug oxaliplatin (OXA) and potential new drugs Pt\n                    <jats:sub>2<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    Spm (Pt\n                    <jats:sub>2<\/jats:sub>\n                    Spm) and Pd\n                    <jats:sub>2<\/jats:sub>\n                    Cl\n                    <jats:sub>2<\/jats:sub>\n                    Spm (Pd\n                    <jats:sub>2<\/jats:sub>\n                    Spm) (Spm=Spermine) against osteosarcoma (OS). IC\n                    <jats:sub>50<\/jats:sub>\n                    values provided by the (3\u2010(4,5\u2010dimethylthiazol\u20102\u2010yl)\u20102,5\u2010diphenyltetrazolium bromide\u2005(MTT) and Alamar Blue (AB) viability assays and cell density Sulforhodamine B (SRB) test were compared. Values obtained with MTT and AB were generally in agreement, and a tendency for lower IC\n                    <jats:sub>50<\/jats:sub>\n                    values was noted by SRB, for OXA and Pd\n                    <jats:sub>2<\/jats:sub>\n                    Spm. The relative suitability of different assays is discussed for each chelate. The IC\n                    <jats:sub>50<\/jats:sub>\n                    trend: cisplatin (cDDP)\u2248Pd\n                    <jats:sub>2<\/jats:sub>\n                    Spm&lt;OXA&lt;Pt\n                    <jats:sub>2<\/jats:sub>\n                    Spm, confirmed cDDP as the most cytotoxic Pt\n                    <jats:sup>II<\/jats:sup>\n                    \u2010agent against OS and revealed a promising performance for Pd\n                    <jats:sub>2<\/jats:sub>\n                    Spm. Metal chelates were also tested in combination with doxorubicin and methotrexate, the results showing that, in general, cocktails achieved comparable end\u2010performances to that of combined cDDP, indicating that drug combination may circumvent low single\u2010drug cytotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/slct.202001361","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T15:39:12Z","timestamp":1590593952000},"page":"5993-6000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cytotoxicity of Platinum and Palladium Chelates against Osteosarcoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Ana S.","family":"Martins","sequence":"first","affiliation":[{"name":"University of Coimbra Unidade\u2005de\u2005I&amp;D Qu\u00edmica-F\u00edsica Molecular, Department of Chemistry, Rua Larga  3004-535 Coimbra Portugal"},{"name":"CICECO-Aveiro Institute of Materials (CICECO\/UA), Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de\u2005Santiago  3810-193 Aveiro Portugal"}]},{"given":"Ana L.M.","family":"Batista de Carvalho","sequence":"additional","affiliation":[{"name":"University of Coimbra Unidade\u2005de\u2005I&amp;D Qu\u00edmica-F\u00edsica Molecular, Department of Chemistry, Rua Larga  3004-535 Coimbra Portugal"}]},{"given":"In\u00eas","family":"Lamego","sequence":"additional","affiliation":[{"name":"University of Coimbra Unidade\u2005de\u2005I&amp;D Qu\u00edmica-F\u00edsica Molecular, Department of Chemistry, Rua Larga  3004-535 Coimbra Portugal"},{"name":"CICECO-Aveiro Institute of Materials (CICECO\/UA), Department of Chemistry University of Aveiro, Campus Universit\u00e1rio de\u2005Santiago  3810-193 Aveiro Portugal"}]},{"given":"M.\u25aa Paula. 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