{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:07:19Z","timestamp":1761484039647,"version":"build-2065373602"},"reference-count":24,"publisher":"Wiley","issue":"37","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistrySelect"],"published-print":{"date-parts":[[2021,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The main etiological agents in dermatophytosis of human skin and nails are Trichophyton, in particular\n                    <jats:italic>Trichophyton rubrum<\/jats:italic>\n                    (\n                    <jats:italic>T. rubrum<\/jats:italic>\n                    ) and\n                    <jats:italic>Trichophyton mentagrophytes<\/jats:italic>\n                    (\n                    <jats:italic>T. mentagrophytes<\/jats:italic>\n                    ). A new series of twenty\u2010three 3\u2010 and 4\u2010arylcoumarins was synthesized and the antifungal activities against clinical isolates of\n                    <jats:italic>T. rubrum<\/jats:italic>\n                    and\n                    <jats:italic>T. mentagrophytes<\/jats:italic>\n                    were evaluated. Sixteen out of twenty\u2010three molecules exhibited antifungal activity against one or both fungi strains. In some cases, the activity against\n                    <jats:italic>T. rubrum<\/jats:italic>\n                    has been comparable to fluconazole, one of the standards, being 8\u2010methoxy\u20103\u2010(4\u2019\u2010nitrophenyl)coumarin (\n                    <jats:bold>16<\/jats:bold>\n                    ) the best compound within this series (minimum inhibitory concentration, MIC=6.25\u2005\u03bcg\/mL). The preliminary structure\u2010activity relationship study showed that the antifungal activity depends on the position and nature of the substitution patterns. The cytotoxicity of eleven compounds on D\u2010384 (astrocytoma), A\u2010549 (lung cancer) and RKO (colorectal cancer) cell lines was also performed. With the aim of deeply understand the potential of these molecules as hits to develop new drugs, the theoretical absorption, distribution, metabolism and excretion (ADME) properties of the active compounds were calculated.\n                  <\/jats:p>","DOI":"10.1002\/slct.202103099","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T08:05:47Z","timestamp":1633507547000},"page":"9981-9989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Study of a Selected Series of 3\u2010 and 4\u2010Arylcoumarins as Antifungal Agents against Dermatophytic Fungi:\n                    <i>T. rubrum<\/i>\n                    and\n                    <i>T. mentagrophytes<\/i>"],"prefix":"10.1002","volume":"6","author":[{"given":"Carmen Luc\u00eda","family":"Lopez Cisneros","sequence":"first","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Facultad de Ciencias Qu\u00edmicas Universidad de Cuenca  Av. 12 de abril s\/n. Cuenca Ecuador"}]},{"given":"Mar\u00eda Elena","family":"Cazar Ram\u00edrez","sequence":"additional","affiliation":[{"name":"Grupo de Biotecnolog\u00eda y Biodiversidad. Departamento de Qu\u00edmica Aplicada y Sistemas de Producci\u00f3n. Facultad de Ciencias Qu\u00edmicas. Universidad de Cuenca. Av. 12 de Abril s\/n. Cuenca  Ecuador"}]},{"given":"Natalia","family":"Bailon\u2010Moscoso","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud Universidad T\u00e9cnica Particular de Loja. San Cayetano Alto  calle Par\u00eds s\/n Loja Ecuador"}]},{"given":"Estela","family":"Guardado","sequence":"additional","affiliation":[{"name":"Universidad Estatal Amaz\u00f3nica  Km 2 1\/2 Via Puyo-Tena Puyo Ecuador"}]},{"given":"Fernanda","family":"Borges","sequence":"additional","affiliation":[{"name":"CIQUP\/Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  4169\u2013007 Porto Portugal"}]},{"given":"Eugenio","family":"Uriarte","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultade de Farmacia Universidade Santiago de Compostela  15782 Santiago de Compostela Spain"},{"name":"Instituto de Ciencias Qu\u00edmicas Aplicadas Universidad Aut\u00f3noma de Chile  7500912 Santiago Chile"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3470-8299","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Matos","sequence":"additional","affiliation":[{"name":"CIQUP\/Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade do Porto  4169\u2013007 Porto Portugal"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica Facultade de Farmacia Universidade Santiago de Compostela  15782 Santiago de Compostela Spain"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_7_1_1","first-page":"DC23","volume":"11","author":"Elavarashi E.","year":"2017","journal-title":"J. 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InTech 2015."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18021394"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112832"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-019-09992-x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.03.062"},{"key":"e_1_2_7_14_1","first-page":"801","volume":"6","author":"Sousa M. G.","year":"2015","journal-title":"Front. Microbiol."},{"journal-title":"Dermatology","year":"2021","author":"Shen J. 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Available online: http:\/\/www.molinspiration.com\/services\/properties.html (accessed on 26 July 2021)."}],"container-title":["ChemistrySelect"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/slct.202103099","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/slct.202103099","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/slct.202103099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:01:35Z","timestamp":1761483695000},"score":1,"resource":{"primary":{"URL":"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/slct.202103099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,4]]},"references-count":24,"journal-issue":{"issue":"37","published-print":{"date-parts":[[2021,10,6]]}},"alternative-id":["10.1002\/slct.202103099"],"URL":"https:\/\/doi.org\/10.1002\/slct.202103099","archive":["Portico"],"relation":{},"ISSN":["2365-6549","2365-6549"],"issn-type":[{"type":"print","value":"2365-6549"},{"type":"electronic","value":"2365-6549"}],"subject":[],"published":{"date-parts":[[2021,10,4]]},"assertion":[{"value":"2021-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}