{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T07:20:10Z","timestamp":1775373610363,"version":"3.50.1"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T00:00:00Z","timestamp":1643155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["chemistry-europe.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["ChemistrySelect"],"published-print":{"date-parts":[[2022,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Development of novel antibacterial agents is one of most important aims in the field of medicinal chemistry and drug discovery. A new series of bispyrazole derivatives were synthesized with moderate to excellent yields ranging from 68 to 83\u2009%. The structures of the newly synthesized compounds were confirmed using NMR, GC, IR techniques. The prepared derivatives were screened against Gram\u2010positive bacteria (\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    ) and Gram\u2010negative bacteria (\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    ). All of the new compounds exhibited good to moderate antibacterial activity against Gram\u2010positive and Gram\u2010negative bacteria compared to trimethoprim. The bispyrazole bearing (triflouromethyl)benzene\n                    <jats:bold>8<\/jats:bold>\n                    \u2009\n                    <jats:bold>d<\/jats:bold>\n                    showed significant antibacterial inhibition against all bacteria tested and was found to be more active than trimethoprim in term of inhibition zone. Minimum inhibitory concentration (MIC) showed that the bispyrazoles bearing (methylsulfonyl)benzene\n                    <jats:bold>8<\/jats:bold>\n                    \u2009\n                    <jats:bold>c<\/jats:bold>\n                    and 4\u2010chlorobenzen\n                    <jats:bold>8<\/jats:bold>\n                    \u2009\n                    <jats:bold>e<\/jats:bold>\n                    showed potent inhibition activity against\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    and\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    while The bispyrazole bearing (triflouromethyl)benzene\n                    <jats:bold>8<\/jats:bold>\n                    \u2009\n                    <jats:bold>d<\/jats:bold>\n                    displayed strong inhibitory activity against\n                    <jats:italic>S. aureus<\/jats:italic>\n                    ,\n                    <jats:italic>B. subtilis<\/jats:italic>\n                    ,\n                    <jats:italic>E. coli<\/jats:italic>\n                    and\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    compared to trimethoprim. Molecular docking was investigated for the active compounds and showed promising lead\u2010like characters. These compounds could be employed as prospective lead compounds for the synthesis of novel antibacterial agents with highly potency.\n                  <\/jats:p>","DOI":"10.1002\/slct.202103901","type":"journal-article","created":{"date-parts":[[2022,1,26]],"date-time":"2022-01-26T23:49:37Z","timestamp":1643240977000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Synthesis, Antibacterial Activity, and Molecular Docking Study of Bispyrazole\u2010Based Derivatives as Potential Antibacterial Agents"],"prefix":"10.1002","volume":"7","author":[{"given":"Ghazwan","family":"Ali Salman","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Sciences Mustansiriyah University  10052 Baghdad Iraq"}]},{"given":"Dhafer","family":"S. Zinad","sequence":"additional","affiliation":[{"name":"Applied Science Department University of Technology  Baghdad 10001 Iraq"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-3752","authenticated-orcid":false,"given":"Ahmed","family":"Mahal","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemical Analysis College of Health Technology Cihan University-Erbil, Erbil  Kurdistan Region Iraq"},{"name":"Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden Chinese Academy of Sciences  Guangzhou 510650 People's Republic of China"},{"name":"Guangzhou HC Pharmaceutical Co., Ltd  Guangzhou 510663 People's Republic of China"}]},{"given":"Mohammad","family":"Rizki Fadhil Pratama","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Health Sciences Universitas Muhammadiyah Palangkaraya  Palangka Raya 73111 Indonesia"},{"name":"Doctoral Program of Pharmaceutical Sciences Department of Pharmaceutical Sciences Faculty of Pharmacy Airlangga University  Surabaya 60115 Indonesia"}]},{"given":"Meiato","family":"Duan","sequence":"additional","affiliation":[{"name":"Bostal Drug Delivery Co., Ltd.  Guangzhou 510530 People's Republic of China"},{"name":"School of Traditional Chinese Medicine Southern Medical University  Guangzhou 510515 People's Republic of China"}]},{"given":"Anas","family":"Alkhouri","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemical Analysis College of Health Technology Cihan University-Erbil, Erbil  Kurdistan Region Iraq"}]},{"given":"Ahmed","family":"Alamiery","sequence":"additional","affiliation":[{"name":"Department of Chemical and Process Engineering Faculty of Engineering and Built Enviroment Universiti Kebangsaan Malaysia (UKM)  P. O. Box 43000 Bangi 43600 Malaysia"},{"name":"Energy and Renewable Energies Technology Center University of Technology, Industrial Street  Baghdad 10066 Iraq"}]}],"member":"311","published-online":{"date-parts":[[2022,1,26]]},"reference":[{"key":"e_1_2_8_1_1","unstructured":"World Health Organization New report calls for urgent action to avert antimicrobial resistance crisis. 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