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A modified method for preparation of sterically hindered 2\u2010aminopyrimidines in two steps was demonstrated. The evaluation of their\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    activity against\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    H37Rv showed different MIC values (up to 0.91\u2005\u03bcM for ketone\n                    <jats:bold>39<\/jats:bold>\n                    ). Compound\n                    <jats:bold>35<\/jats:bold>\n                    demonstrated moderate (8.23\u2005\u03bcM), but sustainable activity toward a collection of drug\u2010resistant\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    strains. Many of the compounds (especially among 2\u2010aminopyridines\n                    <jats:bold>42<\/jats:bold>\n                    \u2013\n                    <jats:bold>56<\/jats:bold>\n                    ) exhibited good to excellent activity against different strains of pathogenic bacteria and fungi (MIC up to 0.60\u2005\u03bcM for compound\n                    <jats:bold>50<\/jats:bold>\n                    ), compared with reference antibiotics. Many of the newly designed compounds possess also\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    cytotoxicity.\n                  <\/jats:p>","DOI":"10.1002\/slct.202201339","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T07:43:16Z","timestamp":1651563796000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synthesis, Characterization and Complex Evaluation of Antibacterial Activity and Cytotoxicity of New Arylmethylidene Ketones and Pyrimidines with Camphane Skeletons"],"prefix":"10.1002","volume":"7","author":[{"given":"Ivaylo M.","family":"Slavchev","sequence":"first","affiliation":[{"name":"Institute of Organic Chemistry with Centre of Phytochemistry Bulgarian Academy of Sciences  bl. 9, Acad. G. Bonchev str. 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