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Among these, the copper(I)\u2010catalyzed azide\u2010alkyne cycloaddition (CuAAC) has emerged as a key strategy for the green synthesis of triazole\u2010based molecules, renowned for their stability, biocompatibility, and broad\u2010spectrum biological activities. The environmentally friendly nature of click chemistry, characterized by atom economy, reduced waste, and the use of benign solvents aligns with the growing emphasis on sustainable drug discovery. This review explores recent advancements in the green synthesis of biologically active triazoles via click chemistry, with a focus on their applications in antimicrobial and anticancer research. Additionally, alternative click approaches such as strain\u2010promoted azide\u2010alkyne cycloaddition (SPAAC) is discussed in the context of biorthogonal applications, highlighting their impact on chemical biology. By integrating these sustainable strategies, the development of functionalized triazoles presents a promising avenue for biomedical innovation while addressing the urgent need for eco\u2010conscious synthetic practices.<\/jats:p>","DOI":"10.1002\/slct.202501593","type":"journal-article","created":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:52:14Z","timestamp":1756216334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Environmentally Benign Click Chemistry: A Path to Biologically Active Triazoles"],"prefix":"10.1002","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-1337","authenticated-orcid":false,"given":"Mohmmad Younus","family":"Wani","sequence":"first","affiliation":[{"name":"Department of Chemistry College of Science University of Jeddah  Jeddah 21589 Saudi Arabia"}]},{"given":"Majed Saeed Saleh","family":"Alghamdi","sequence":"additional","affiliation":[{"name":"Department 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