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Advances in microfabrication and nanotechnology offer new tools to investigate the complex signaling cascade induced by the components of the extracellular matrix and consequently allow cellular responses to be tailored through the mimicking of some elements of the signaling paths. Patterning methods and selective chemical modification schemes at different length scales can provide biocompatible surfaces that control cellular interactions on the micrometer and sub\u2010micrometer scales on which cells are organized. In this review,  the potential of chemically and topographically structured micro\u2010 and nanopolymer surfaces are discussed in hopes of a better understanding of cell\u2013biomaterial interactions, including the recent use of biomimetic approaches or stimuli\u2010responsive macromolecules. Additionally, the focus will be on how the knowledge obtained using these surfaces can be incorporated to design biocompatible materials for various biomedical applications, such as tissue engineering, implants, cell\u2010based biosensors, diagnostic systems, and basic cell biology. The review focusses on the research carried out during the last decade.<\/jats:p>","DOI":"10.1002\/smll.201000233","type":"journal-article","created":{"date-parts":[[2010,9,16]],"date-time":"2010-09-16T11:51:44Z","timestamp":1284637904000},"page":"2208-2220","source":"Crossref","is-referenced-by-count":315,"title":["Controlling Cell Behavior Through the Design of Polymer Surfaces"],"prefix":"10.1002","volume":"6","author":[{"given":"Nat\u00e1lia M.","family":"Alves","sequence":"first","affiliation":[]},{"given":"Iva","family":"Pashkuleva","sequence":"additional","affiliation":[]},{"given":"Rui L.","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o F.","family":"Mano","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2010,9,16]]},"reference":[{"key":"e_1_2_7_1_2","volume-title":"Engines of creation: The coming era of nanotechnology","author":"Drexler E.","year":"1986"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1039\/b614008d"},{"key":"e_1_2_7_2_3","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5415.765"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(07)83005-6"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0286(01)00005-5"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(01)00424-0"},{"key":"e_1_2_7_5_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00427-1"},{"key":"e_1_2_7_5_4","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.200300868"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31049"},{"key":"e_1_2_7_6_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4931(01)00396-4"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.07.007"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.05.030"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.11.016"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.01.029"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4636(20000905)51:3<430::AID-JBM18>3.0.CO;2-C"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(07)83004-4"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00475-7"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.12.020"},{"key":"e_1_2_7_13_4","doi-asserted-by":"publisher","DOI":"10.1021\/bm0503423"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma990751p"},{"key":"e_1_2_7_14_3","doi-asserted-by":"publisher","DOI":"10.1021\/bm0611533"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.31697"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.101"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30870"},{"key":"e_1_2_7_17_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.10.025"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.30143"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.05.055"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.03.013"},{"key":"e_1_2_7_20_3","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2269"},{"key":"e_1_2_7_20_4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2007.12.026"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31400"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.32210"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.200803680"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1021\/ma047934i"},{"key":"e_1_2_7_24_3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tca.2005.01.066"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/bm050323t"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.tea.2007.0270"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/cm.20041"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200405004"},{"key":"e_1_2_7_28_3","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(00)00350-1"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1021\/la026403p"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986708783885219"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1021\/la803577t"},{"key":"e_1_2_7_31_3","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200400106"},{"key":"e_1_2_7_32_2","first-page":"1","volume":"102","author":"Semler E. 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