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The resulting difference in curvature pressure drives the flow and creates a concentration gradient by convection. Experiments and theoretical models characterize the flows and gradient profiles and their dependence on the fluid volumes, properties, and stripe geometry. A bench\u2010top rapid prototyping method is outlined to allow the user to design and fabricate the coated slides using only tape and hydrophobic spray. The rapid prototyping method is compatible with microwell arrays, allowing soluble gradients to be applied to cells in shear\u2010protected microwells. The method\u2019s simplicity makes it accessible to virtually any researcher or student and its use of passive mechanisms makes it ideal for field use and compatible with point\u2010of\u2010care and global health initiatives.<\/jats:p>","DOI":"10.1002\/smll.201002088","type":"journal-article","created":{"date-parts":[[2011,2,26]],"date-time":"2011-02-26T15:41:22Z","timestamp":1298734882000},"page":"892-901","source":"Crossref","is-referenced-by-count":42,"title":["Surface\u2010Tension\u2010Driven Gradient Generation in a Fluid Stripe for Bench\u2010Top and Microwell Applications"],"prefix":"10.1002","volume":"7","author":[{"given":"Matthew J.","family":"Hancock","sequence":"first","affiliation":[]},{"given":"Jiankang","family":"He","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o F.","family":"Mano","sequence":"additional","affiliation":[]},{"given":"Ali","family":"Khademhosseini","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2011,2,25]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1021\/la7033164"},{"key":"e_1_2_7_1_3","doi-asserted-by":"publisher","DOI":"10.1039\/B711887B"},{"key":"e_1_2_7_1_4","doi-asserted-by":"publisher","DOI":"10.1002\/cjce.20411"},{"key":"e_1_2_7_1_5","doi-asserted-by":"publisher","DOI":"10.1039\/c0ib00055h"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac001132d"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.021"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/b706340g"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/B815990D"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2009.12.012"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04163"},{"key":"e_1_2_7_7_3","volume-title":"Microfluidics for Biotechnology","author":"Berthier J.","year":"2006"},{"key":"e_1_2_7_7_4","doi-asserted-by":"publisher","DOI":"10.1039\/B611455E"},{"key":"e_1_2_7_7_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.11.016"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810903105"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/b407623k"},{"key":"e_1_2_7_9_3","doi-asserted-by":"publisher","DOI":"10.1039\/b204381e"},{"key":"e_1_2_7_9_4","doi-asserted-by":"publisher","DOI":"10.1021\/ac0261449"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/B917493A"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.200901311"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/la052574t"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5506.1023"},{"key":"e_1_2_7_13_3","doi-asserted-by":"publisher","DOI":"10.1021\/la010589v"},{"key":"e_1_2_7_13_4","doi-asserted-by":"publisher","DOI":"10.1143\/APEX.3.085205"},{"key":"e_1_2_7_13_5","unstructured":"d)C. 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