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Neonatal Fc receptor (FcRn)\u2010mediated transcytosis has been recently proposed as a strategy to increase the transport of drugs across the intestinal epithelium. FcRn\u2010targeted nanoparticles (NPs) could hijack the FcRn transcytotic pathway and cross the epithelial cell layer. In this study, a novel nanoparticulate system for insulin delivery based on porous silicon NPs is proposed. After surface conjugation with albumin and loading with insulin, the NPs are encapsulated into a pH\u2010responsive polymeric particle by nanoprecipitation. The developed NP formulation shows controlled size and homogeneous size distribution. Transmission electron microscopy (TEM) images show successful encapsulation of the NPs into pH\u2010sensitive polymeric particles. No insulin release is detected at acidic conditions, but a controlled release profile is observed at intestinal pH. Toxicity studies show high compatibility of the NPs with intestinal cells. In vitro insulin permeation across the intestinal epithelium shows approximately fivefold increase when insulin is loaded into FcRn\u2010targeted NPs. Overall, these FcRn\u2010targeted NPs offer a toolbox in the development of targeted therapies for oral delivery of insulin.<\/jats:p>","DOI":"10.1002\/smll.201800462","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T06:01:56Z","timestamp":1527832916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Engineered Multifunctional Albumin\u2010Decorated Porous Silicon Nanoparticles for FcRn Translocation of Insulin"],"prefix":"10.1002","volume":"14","author":[{"given":"Jo\u00e3o P.","family":"Martins","sequence":"first","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Roberto","family":"D'Auria","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"},{"name":"Department of Biomolecular Sciences School of Pharmacy University of Urbino  Urbino (PU) 61029 Italy"}]},{"given":"Dongfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"},{"name":"Helsinki Institute of Life Science (HiLIFE) University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"Flavia","family":"Fontana","sequence":"additional","affiliation":[{"name":"Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki  Helsinki FI\u201000014 Finland"}]},{"given":"M\u00f3nica P. 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