{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:44:25Z","timestamp":1762659865386,"version":"3.41.2"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004199","name":"Okinawa Institute of Science and Technology Graduate University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002770","name":"Cabinet Office, Government of Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Small"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fluid\u2013structure interactions lie at the heart of the complex, and often highly coordinated, motions of actively driven microscale biological systems (e.g., translating cilia, flagella, and motile cells). Due to the highly viscoelastic nature of most relevant biological fluids and the small length scales involved, the viscous and inertial forces in such flows are dominated by elasticity. However, elastic effects are often overlooked in studies seeking to address phenomena like the synchronization of beating cilia. In this study, unique microfluidic experiments are presented to demonstrate that inertia\u2010free viscoelastic flows can lead to highly regular beating of an immersed (passive) flexible structure, herein named \u201cpurely\u2010elastic\u201d fluid\u2013structure interaction. It is also shown how two such flexible structures can achieve an extraordinary degree of synchronization, with a correlation coefficient approaching unity. The synchronization is a result of the generation of localized elastic stresses in the fluid that effectively link the two objects. These purely elastic interactions may be important to consider toward developing a complete understanding of the motions of microscale biological systems.<\/jats:p>","DOI":"10.1002\/smll.201903872","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T14:46:50Z","timestamp":1574261210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Purely Elastic Fluid\u2013Structure Interactions in Microfluidics: Implications for Mucociliary Flows"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0351-2100","authenticated-orcid":false,"given":"Cameron C.","family":"Hopkins","sequence":"first","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University Onna\u2010son Okinawa 904\u20100495 Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1884-4100","authenticated-orcid":false,"given":"Simon J.","family":"Haward","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University Onna\u2010son Okinawa 904\u20100495 Japan"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-6264","authenticated-orcid":false,"given":"Amy Q.","family":"Shen","sequence":"additional","affiliation":[{"name":"Okinawa Institute of Science and Technology Graduate University Onna\u2010son Okinawa 904\u20100495 Japan"}]}],"member":"311","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bioeng.4.112601.125916"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05058"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13118"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1119\/1.10903"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.82.1590"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/35073524"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1083694"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.92.094501"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-006-9177-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/jfm.2017.15"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevFluids.3.063301"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0sm01121e"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1218869110"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2015.11.010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phpro.2012.10.070"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2018.12.005"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8SM02099J"},{"volume-title":"Fluid\u2010Structure Interactions in Low\u2010Reynolds\u2010Number Flows","year":"2016","author":"Stone H. 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