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Current approaches to monitoring of chemotherapy\u2010induced cardiotoxicity (CIC) as well as model systems that develop in vivo or in vitro CIC platforms fail to notice early signs of CIC. Moreover, breast cancer (BC) patients with preexisting cardiac dysfunctions may lead to different incident levels of CIC. Here, a model is presented for investigating CIC where not only induced pluripotent stem cell (iPSC)\u2010derived cardiac tissues are interacted with BC tissues on a dual\u2010organ platform, but electrochemical immuno\u2010aptasensors can also monitor cell\u2010secreted multiple biomarkers. Fibrotic stages of iPSC\u2010derived cardiac tissues are promoted with a supplement of transforming growth factor\u2010\u03b2\u20091 to assess the differential functionality in healthy and fibrotic cardiac tissues after treatment with doxorubicin (DOX). The production trend of biomarkers evaluated by using the immuno\u2010aptasensors well\u2010matches the outcomes from conventional enzyme\u2010linked immunosorbent assay, demonstrating the accuracy of the authors\u2019 sensing platform with much higher sensitivity and lower detection limits for early monitoring of CIC and BC progression. Furthermore, the versatility of this platform is demonstrated by applying a nanoparticle\u2010based DOX\u2010delivery system. 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