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Metal\u2010organic frameworks (MOFs) with open metal sites are promising carriers for NO therapies but delivering it over an extended period in biological media remains a great challenge due to i) a fast degradation of the material in body fluids and\/or ii) a rapid replacement of NO by water molecules onto the Lewis acid sites. Here, a new ultra\u2010narrow pores Fe bisphosphonate MOF, denoted MIP\u2010210(Fe) or Fe(H<jats:sub>2<\/jats:sub>O)(Hmbpa) (H<jats:sub>4<\/jats:sub>mbpa = p\u2010xylenediphosphonic acid) is described that adsorbs NO due to an unprecedented sorption mechanism: coordination of NO through the Fe(III) sites is unusually preferred, replacing bound water, and creating a stable interaction with the free H<jats:sub>2<\/jats:sub>O and P\u2010OH groups delimiting the ultra\u2010narrow pores. This, associated with the high chemical stability of the MOF in body fluids, enables an unprecedented slow replacement of NO by water molecules in biological media, achieving an extraordinarily extended NO delivery time over at least 70\u00a0h, exceeding by far the NO kinetics release reported with others porous materials, paving the way for the development of safe and successful gas therapies.<\/jats:p>","DOI":"10.1002\/smll.202405649","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T07:52:33Z","timestamp":1726127553000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Ultra\u2010Microporous Fe\u2010MOF with Prolonged NO Delivery in Biological Media for Therapeutic Application"],"prefix":"10.1002","volume":"20","author":[{"given":"Rosana V.","family":"Pinto","sequence":"first","affiliation":[{"name":"CERENA Departamento de Engenharia Qu\u00edmica Instituto Superior T\u00e9cnico Universidade de Lisboa  Lisboa 1049\u2010001 Portugal"},{"name":"CQE \u2010Centro de Qu\u00edmica Estrutural Institute of Molecular Sciences Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade de Lisboa  Lisboa 1749\u2010016 Portugal"}]},{"given":"Chen\u2010Chen","family":"Cao","sequence":"additional","affiliation":[{"name":"Institut des Mat\u00e9riaux Poreux de Paris Ecole Normale Sup\u00e9rieure ESPCI Paris CNRS PSL University  Paris 75005 France"},{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510275 China"}]},{"given":"Pengbo","family":"Lyu","sequence":"additional","affiliation":[{"name":"ICGM Univ. Montpellier CNRS ENSCM  Montpellier 34293 France"},{"name":"Hunan Provincial Key Laboratory of Thin Film Materials and Devices School of Materials Science and Engineering Xiangtan University  Xiangtan 411105 China"}]},{"given":"Iurii","family":"Dovgaliuk","sequence":"additional","affiliation":[{"name":"Institut des Mat\u00e9riaux Poreux de Paris Ecole Normale Sup\u00e9rieure ESPCI Paris CNRS PSL University  Paris 75005 France"}]},{"given":"William","family":"Shepard","sequence":"additional","affiliation":[{"name":"Synchrotron SOLEIL L'Orme des Merisiers  D\u00e9partementale 128 Saint\u2010Aubin 91190 France"}]},{"given":"Eric","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"Institut de Chimie Mol\u00e9culaire et des Mat\u00e9riaux d'Orsay Universit\u00e9 Paris\u2010Saclay CNRS ICMMO  Orsay Cedex 91405 France"}]},{"given":"Cheng\u2010Yong","family":"Su","sequence":"additional","affiliation":[{"name":"MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional Materials School of Chemistry Sun Yat\u2010Sen University  Guangzhou 510275 China"},{"name":"State Key Laboratory of Applied Organic Chemistry Lanzhou University  Lanzhou 730000 China"}]},{"given":"Guillaume","family":"Maurin","sequence":"additional","affiliation":[{"name":"ICGM Univ. Montpellier CNRS ENSCM  Montpellier 34293 France"}]},{"given":"Fernando","family":"Antunes","sequence":"additional","affiliation":[{"name":"CQE \u2010Centro de Qu\u00edmica Estrutural Institute of Molecular Sciences Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade de Lisboa  Lisboa 1749\u2010016 Portugal"}]},{"given":"Jo\u00e3o","family":"Pires","sequence":"additional","affiliation":[{"name":"CQE \u2010Centro de Qu\u00edmica Estrutural Institute of Molecular Sciences Departamento de Qu\u00edmica e Bioqu\u00edmica Faculdade de Ci\u00eancias Universidade de Lisboa  Lisboa 1749\u2010016 Portugal"}]},{"given":"V\u00e2nia","family":"Andr\u00e9","sequence":"additional","affiliation":[{"name":"CQE \u2013 Centro de Qu\u00edmica Institute of Molecular Sciences Instituto Superior T\u00e9cnico Universidade de Lisboa  Av. 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