{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:18:53Z","timestamp":1777504733625,"version":"3.51.4"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T00:00:00Z","timestamp":1715385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101104"],"award-info":[{"award-number":["32101104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202663"],"award-info":[{"award-number":["82202663"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2023AH053289"],"award-info":[{"award-number":["2023AH053289"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Small Science"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\nSignificance of endogenous mineralization in bone reconstruction is paramount, as it facilitates the accumulation of calcium ions for bone tissue deposition. However, conventional 3D\u2010printed scaffolds lack the capacity for calcium ion enrichment and mineralization, coupled with their low bone inductive activity. Inspired from the development of natural plant seeds, a biomimetic 3D printing scaffold is developed by implanting photosensitive black phosphorus \u201cbone seeds\u201d (BS), guiding a sequential process mirroring rooting (osteoblast recruitment), sprouting (fibrous callus mineralization), flowering (osseous callus formation), and fruiting (callus plasticity). BS were trapped onto porous 3D polycaprolactone (PCL) scaffolds with aminated surfaces <jats:italic>via<\/jats:italic> electrostatic interactions between phosphates and amino groups, creating the PCL\u2010BS scaffold that can actively capture calcium ions for accelerating the endogenous regeneration of critical bone defects. In vitro and in\u2009vivo experiments show that the PCL\u2010BS scaffold has good biocompatibility and strong osteogenic ability for rapid new bone regeneration under near\u2010infrared (NIR)\u00a0stimulation. In addition, whole transcriptome sequencing analysis is performed to reveal the transcriptomic mechanism of BS involved in signal transduction and network regulation during bone regeneration. This NIR light\u2010regulated biomimetic BS inspired by seed planting, introduces a pioneering concept in the design of 3D printing bone repair scaffolds.<\/jats:p>","DOI":"10.1002\/smsc.202300357","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T07:24:43Z","timestamp":1715412283000},"source":"Crossref","is-referenced-by-count":10,"title":["Bioinspired Bone Seed 3D\u2010Printed Scaffold via Trapping Black Phosphorus Nanosheet for Bone Regeneration"],"prefix":"10.1002","volume":"4","author":[{"given":"Zhengwei","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}]},{"given":"Zhijie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"},{"name":"Department of Orthopaedic Surgery Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 200127 P. R. China"}]},{"given":"Yuan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}]},{"given":"Liang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 200127 P. R. China"}]},{"given":"Minglong","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}]},{"given":"Ningtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics The First Affiliated Hospital of Anhui Medical University  218 Jixi Road Shushan District Hefei Anhui 230022 P. R. China"}]},{"given":"Zhanchun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Renji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai 200127 P. R. China"}]},{"given":"Catarina Leite","family":"Pereira","sequence":"additional","affiliation":[{"name":"I3\u2010Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o Em Sa\u00fade and INEB\u2010Instituto de Engenharia Biom\u00e9dica Universidade Do Porto  Rua Alfredo Allen 208 4200\u2010135 Porto Portugal"}]},{"given":"Yunhai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"},{"name":"Department of Orthopedics Wuxi Branch of Ruijin Hospital  Wuxi Jiangsu 214106 P. R. China"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5763-7553","authenticated-orcid":false,"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"I3\u2010Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o Em Sa\u00fade and INEB\u2010Instituto de Engenharia Biom\u00e9dica Universidade Do Porto  Rua Alfredo Allen 208 4200\u2010135 Porto Portugal"},{"name":"IUCS\u2010Instituto Universit\u00e1rio de Ci\u00eancias da Sa\u00fade CESPU  Rua Central de Gandra 1317 4585\u2010116 Gandra Portugal"}]},{"given":"Wenguo","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine  197 Ruijin 2nd Road Shanghai 200025 P. R. China"}]}],"member":"311","published-online":{"date-parts":[[2024,5,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00279-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0471-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2023.10.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0089"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr8004422"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.engreg.2022.09.004"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202202044"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2017.10.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120995"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200043"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/smtd.202300370"},{"key":"e_1_2_8_13_1","first-page":"e2304824","volume":"12","author":"Qiu M.","year":"2023","journal-title":"Adv. Sci."},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2020.06.007"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1063\/5.0121241"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201901560"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.8b21179"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2018.05.022"},{"key":"e_1_2_8_19_1","first-page":"12","volume":"2021","author":"Wu Z.","year":"2021","journal-title":"Research"},{"key":"e_1_2_8_20_1","first-page":"0255","volume":"6","author":"Yi X.","year":"2021","journal-title":"Research"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/SMMD.84"},{"key":"e_1_2_8_22_1","first-page":"4185","volume":"10","author":"Zhang X.","year":"2019","journal-title":"Chem. Lett."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.06.039"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004793"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202100894"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100834"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20210018"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmt.2022.11.007"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/VIW.20200060"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c09174"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.168"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.002"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0246-y"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000439"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2018.12.008"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.04.014"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.nanolett.9b03980"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04873-7"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202105586"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2022.02.024"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42765-022-00229-5"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02256-2"}],"container-title":["Small Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/smsc.202300357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T04:27:40Z","timestamp":1718771260000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smsc.202300357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,11]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/smsc.202300357"],"URL":"https:\/\/doi.org\/10.1002\/smsc.202300357","archive":["Portico"],"relation":{},"ISSN":["2688-4046","2688-4046"],"issn-type":[{"value":"2688-4046","type":"print"},{"value":"2688-4046","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,11]]},"article-number":"2300357"}}