{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:42:31Z","timestamp":1766486551237},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2004,1,29]],"date-time":"2004-01-29T00:00:00Z","timestamp":1075334400000},"content-version":"vor","delay-in-days":3894,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Yeast"],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have previously shown that the heat\u2010induced enhanced decay of yeast mRNAs encoding ribosomal proteins (rp\u2010mRNAs) requires ongoing transcription during the heat treatment [Herruer <jats:italic>et al.<\/jats:italic> (1988) <jats:italic>Nucl. Acids Res.<\/jats:italic> <jats:bold>16<\/jats:bold>, 7917]. In order to determine whether this requirement reflects the need for heat\u2010shock protein (hsp), we analysed the effect of heat shock on rp\u2010mRNA levels in several yeast strains in which each of the heat\u2010shock genes encoding hsp26, hsp35 or hsp83 had been individually disrupted. In all three strains we still observed increased degradation of rp\u2010mRNAs immediately after the temperature shift, demonstrating that hsp26, hsp35 and hsp83 are not required for this effect. Accelerated turnover of rp\u2010mRNA was also found to occur upon raising the growth temperature of a mutant strain that contains a disruption of the gene specifying the heat\u2010shock transcription factor and in wild\u2010type yeast cells treated with canavanine, an arginine analogue that will be incorporated into all known hsps and that is known to cause misfolding of the polypeptide chain. Latter observation suggests that enhanced rp\u2010mRNA decay is a more general stress\u2010related phenomenon. Taken together, these data strongly indicate that the <jats:italic>trans<\/jats:italic>\u2010acting factor required for the increase in the rate of degradation of rp\u2010mRNAs upon stress is not one of the known yeast hsps.<\/jats:p>","DOI":"10.1002\/yea.320090604","type":"journal-article","created":{"date-parts":[[2005,5,28]],"date-time":"2005-05-28T23:43:13Z","timestamp":1117323793000},"page":"583-588","source":"Crossref","is-referenced-by-count":6,"title":["Known heat\u2010shock proteins are not responsible for stress\u2010induced rapid degradation of ribosomal protein mRNAs in yeast"],"prefix":"10.1002","volume":"9","author":[{"given":"Lisete","family":"Galego","sequence":"first","affiliation":[]},{"given":"Isabel","family":"Barahona","sequence":"additional","affiliation":[]},{"given":"Ana\u2010Paula","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Claudina","family":"Rodrigues\u2010Pousada","sequence":"additional","affiliation":[]},{"given":"Peter","family":"Vreken","sequence":"additional","affiliation":[]},{"given":"Hendrik A.","family":"Rau\u00e9","sequence":"additional","affiliation":[]},{"given":"Rudi J.","family":"Planta","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,1,29]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(89)90234-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1988.tb14218.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.16.7917"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/12.17.6685"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.22.120188.003215"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.5.1602"},{"key":"e_1_2_1_8_1","first-page":"5","volume-title":"Heat Shock Response","author":"Nover L.","year":"1991"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-9525(88)90042-X"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60007-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"9094","DOI":"10.1016\/S0021-9258(19)76513-2","article-title":"Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae","volume":"263","author":"Remacha M.","year":"1988","journal-title":"J. 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