{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:34:34Z","timestamp":1769308474399,"version":"3.49.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytical Biochemistry"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1006\/abio.1999.4386","type":"journal-article","created":{"date-parts":[[2003,5,19]],"date-time":"2003-05-19T12:51:21Z","timestamp":1053348681000},"page":"104-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Ion-Pairing High-Performance Liquid Chromatographic Method for the Detection of N-Acetylaspartate and N-Acetylglutamate in Cerebral Tissue Extracts"],"prefix":"10.1006","volume":"277","author":[{"given":"Barbara","family":"Tavazzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Vagnozzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donato","family":"Di Pierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Maria","family":"Amorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Fazzina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Signoretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Marmarou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Lazzarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/abio.1999.4386_RF1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1046\/j.1471-4159.1997.68020675.x","article-title":"Transient elevation of interstitial N-acetylaspartate in reversible global brain ischemia","volume":"68","author":"Sager","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1006\/abio.1999.4386_RF2","first-page":"420","article-title":"Cell type-specific fingerprinting of meningioma and meningeal cells by proton nuclear magnetic resonance spectroscopy","volume":"55","author":"Florian","year":"1995","journal-title":"Cancer Res."},{"key":"10.1006\/abio.1999.4386_RF3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1161\/01.STR.23.11.1566","article-title":"Early time course of N-acetylaspartate, creatine and phosophocreatine, and compounds containing choline in the brain after acute stroke","volume":"23","author":"Gideon","year":"1992","journal-title":"Stroke"},{"key":"10.1006\/abio.1999.4386_RF4","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0006-8993(92)90925-Y","article-title":"Decrease brain N-acetylaspartate in Huntington's disease","volume":"580","author":"Dunlop","year":"1992","journal-title":"Brain Res."},{"key":"10.1006\/abio.1999.4386_RF5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/ajmg.1320290234","article-title":"Aspartoacylase deficiency and N-acetylaspartic aciduria in patients with Canavan disease","volume":"29","author":"Matalon","year":"1988","journal-title":"Am. J. Med. Genet."},{"key":"10.1006\/abio.1999.4386_RF6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1212\/WNL.43.3_Part_1.509","article-title":"Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: In vivo1H magnetic resonance spectroscopic imaging","volume":"43","author":"Meyerhoff","year":"1993","journal-title":"Neurology"},{"key":"10.1006\/abio.1999.4386_RF7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1203\/00006450-199502000-00003","article-title":"Regional metabolic assessment of human brain during development by proton magnetic resonance spectroscopy in vivo and high-performance liquid chromatography\/gas chromatography in autopsy tissue","volume":"37","author":"H\u00fcppi","year":"1995","journal-title":"Pediatr. Res."},{"key":"10.1006\/abio.1999.4386_RF8","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1111\/j.1471-4159.1984.tb12854.x","article-title":"N-Acetyl-aspartyl-glutamate: regional levels in rat brain and the effects of brain lesions as determined by a new HPLC method","volume":"43","author":"Koller","year":"1984","journal-title":"J. Neurochem."},{"key":"10.1006\/abio.1999.4386_RF9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/jcbfm.1995.79","article-title":"Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat","volume":"15","author":"Sager","year":"1995","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1006\/abio.1999.4386_RF10","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0891-5849(92)90143-5","article-title":"MDA, oxypurines and nucleosides relate to reperfusion in short-term incomplete cerebral ischemia in the rat","volume":"123","author":"Lazzarino","year":"1992","journal-title":"Free Radical Biol. Med."},{"key":"10.1006\/abio.1999.4386_RF11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s002210050235","article-title":"Effects of increasing times of incomplete cerebral ischemia upon the energy state and lipid peroxidation in the rat","volume":"117","author":"Vagnozzi","year":"1997","journal-title":"Exp. Brain Res."},{"key":"10.1006\/abio.1999.4386_RF12","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3171\/jns.1994.80.2.0291","article-title":"A new model of diffuse brain injury in rats. I. Pathophysiology and biomechanics","volume":"80","author":"Marmarou","year":"1994","journal-title":"J. Neurosurg."},{"key":"10.1006\/abio.1999.4386_RF13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0003-2697(89)90236-4","article-title":"A method for preparing freeze-clamped tissue samples for metabolite analyses","volume":"181","author":"Lazzarino","year":"1989","journal-title":"Anal. Biochem."},{"key":"10.1006\/abio.1999.4386_RF14","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/abio.1995.0071","article-title":"An ion-pairing high-performance liquid chromatographic method for the direct simultaneous determination of nucleotides, deoxynucleotides, nicotinic coenzymes, oxypurines, nucleosides, and bases in perchloric acid cell extracts","volume":"231","author":"Di Pierro","year":"1995","journal-title":"Anal. Biochem."},{"key":"10.1006\/abio.1999.4386_RF15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0165-3806(84)90150-0","article-title":"Ontogenesis of N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in rat brain","volume":"15","author":"Koller","year":"1984","journal-title":"Dev. Brain Res."},{"key":"10.1006\/abio.1999.4386_RF16","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/BF00965688","article-title":"N-Acetyl-l-glutamate in brain: assay, levels, and regional and subcellular distribution","volume":"16","author":"Alonso","year":"1991","journal-title":"Neurochem. Res."},{"key":"10.1006\/abio.1999.4386_RF17","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0003-2697(91)90477-B","article-title":"Automated precolumn fluorescence labeling by carbodiimide activation of N-acetylaspartate and N-acetylaspartylglutamate applied to an HPLC brain tissue analysis","volume":"196","author":"Korf","year":"1991","journal-title":"Anal. Biochem."},{"key":"10.1006\/abio.1999.4386_RF18","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/BF00965747","article-title":"Brain development: 1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods","volume":"15","author":"Burri","year":"1990","journal-title":"Neurochem. Res."}],"container-title":["Analytical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269799943865?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003269799943865?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T20:18:07Z","timestamp":1757708287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003269799943865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S0003269799943865"],"URL":"https:\/\/doi.org\/10.1006\/abio.1999.4386","relation":{},"ISSN":["0003-2697"],"issn-type":[{"value":"0003-2697","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ion-Pairing High-Performance Liquid Chromatographic Method for the Detection of N-Acetylaspartate and N-Acetylglutamate in Cerebral Tissue Extracts","name":"articletitle","label":"Article Title"},{"value":"Analytical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/abio.1999.4386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}