{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:07:10Z","timestamp":1758816430842},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2000,6]]},"DOI":"10.1006\/bbrc.2000.2905","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T14:49:19Z","timestamp":1032187759000},"page":"95-100","source":"Crossref","is-referenced-by-count":11,"title":["1,25 Dihydroxyvitamin D3 Activates Sphingomyelin Turnover in ROS17\/2.8 Osteosarcoma Cells without Sphingolipid-Induced Changes in Cytosolic Ca2+"],"prefix":"10.1006","volume":"273","author":[{"given":"Riting","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary C.","family":"Farach-Carson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman J.","family":"Karin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/bbrc.2000.2905_RF1","series-title":"Vitamin D","first-page":"149","article-title":"Nuclear vitamin D receptor: Structure-function, phosphorylation, and control of gene transcription","author":"Haussler","year":"1997"},{"key":"10.1006\/bbrc.2000.2905_RF2","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1053\/ajkd.1998.v31.pm9531195","article-title":"Dual 1,25-dihydroxyvitamin D3 signal response pathways in osteoblasts: Cross-talk between genomic and membrane-initiated pathways","volume":"31","author":"Farach-Carson","year":"1998","journal-title":"Am. J. Kidney Dis."},{"key":"10.1006\/bbrc.2000.2905_RF3","doi-asserted-by":"crossref","first-page":"20265","DOI":"10.1016\/S0021-9258(19)47057-9","article-title":"Vitamin D3 metabolites modulate dihydropyridine-sensitive calcium currents in clonal rat osteosarcoma cells","volume":"264","author":"Caffrey","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF4","doi-asserted-by":"crossref","first-page":"8711","DOI":"10.1074\/jbc.275.12.8711","article-title":"Ribozyme ablation demonstrates that the cardiac subtype of the voltage-sensitive calcium channel is the molecular transducer of 1,25-dihydroxyvitamin D3-stimulated calcium influx in osteoblastic cells","volume":"275","author":"Liu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0039-128X(98)00099-3","article-title":"1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2","volume":"64","author":"Boyan","year":"1999","journal-title":"Steroids"},{"key":"10.1006\/bbrc.2000.2905_RF6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/jbmr.5650020204","article-title":"Rapid action of 1,25-dihydroxyvitamin D3 on calcium transport in perfused chick duodenum: effect of inhibitors","volume":"2","author":"Nemere","year":"1987","journal-title":"J. Bone Miner. Res."},{"key":"10.1006\/bbrc.2000.2905_RF7","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/0006-291X(89)91152-2","article-title":"Signal transduction in the onset of terminal keratinocyte differentiation induced by 1 alpha,25-dihydroxyvitamin D3: Role of protein kinase C translocation","volume":"163","author":"Yada","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/bbrc.2000.2905_RF8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2133.1991.tb00566.x","article-title":"1 alpha,25(OH)2 vitamin D3 increases intracellular calcium in human keratinocytes","volume":"124","author":"Bittiner","year":"1991","journal-title":"Br. J. Dermatol."},{"key":"10.1006\/bbrc.2000.2905_RF9","doi-asserted-by":"crossref","first-page":"13168","DOI":"10.1016\/S0021-9258(18)45183-6","article-title":"Effects of vitamin D3 metabolites on cytosolic free calcium in confluent mouse osteoblasts","volume":"262","author":"Lieberherr","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF10","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1210\/endo-127-5-2253","article-title":"Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells","volume":"127","author":"Civitelli","year":"1990","journal-title":"Endocrinology"},{"key":"10.1006\/bbrc.2000.2905_RF11","doi-asserted-by":"crossref","first-page":"29935","DOI":"10.1074\/jbc.273.45.29935","article-title":"Modulation of osteopontin post-translational state by 1,25-(OH)2-vitamin D3. Dependence on Ca2+ influx","volume":"273","author":"Safran","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF12","doi-asserted-by":"crossref","first-page":"19076","DOI":"10.1016\/S0021-9258(19)47268-2","article-title":"Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation","volume":"264","author":"Okazaki","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF13","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0021-9258(18)52461-3","article-title":"Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation","volume":"266","author":"Kim","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF14","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1126\/science.1313189","article-title":"Tumor necrosis factor-alpha activates the sphingomyelin signal transduction pathway in a cell-free system","volume":"255","author":"Dressler","year":"1992","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.2905_RF15","doi-asserted-by":"crossref","first-page":"20044","DOI":"10.1016\/S0021-9258(19)88663-5","article-title":"Interleukin-1-mediated PGE2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide","volume":"267","author":"Ballou","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF16","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1126\/science.8424175","article-title":"Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1 beta","volume":"259","author":"Mathias","year":"1993","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.2905_RF17","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.8079174","article-title":"Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor","volume":"265","author":"Dobrowsky","year":"1994","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.2905_RF18","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/0006-291X(90)92068-B","article-title":"Dexamethasone increases neutral sphingomyelinase activity and sphingosine levels in 3T3-L1 fibroblasts","volume":"167","author":"Ramachandran","year":"1990","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/bbrc.2000.2905_RF19","doi-asserted-by":"crossref","first-page":"19251","DOI":"10.1074\/jbc.271.32.19251","article-title":"The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation","volume":"271","author":"Auge","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1046\/j.1365-2567.1997.d01-2227.x","article-title":"Activation of neutral sphingomyelinase in human neutrophils by polyunsaturated fatty acids","volume":"91","author":"Robinson","year":"1997","journal-title":"Immunology"},{"key":"10.1006\/bbrc.2000.2905_RF21","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1084\/jem.181.6.2059","article-title":"CD28 signals through acidic sphingomyelinase","volume":"181","author":"Boucher","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1006\/bbrc.2000.2905_RF22","first-page":"1547","article-title":"Apoptotic signaling through CD95 (Fas\/Apo-1) activates an acidic sphingomyelinase","volume":"177","author":"Cifone","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1006\/bbrc.2000.2905_RF23","doi-asserted-by":"crossref","first-page":"15823","DOI":"10.1016\/S0021-9258(18)55472-7","article-title":"Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation","volume":"265","author":"Okazaki","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1084\/jem.180.2.525","article-title":"Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis","volume":"180","author":"Haimovitz-Friedman","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1006\/bbrc.2000.2905_RF25","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1006\/bbrc.1995.2339","article-title":"Effects of sphingosine derivatives on MC3T3-E1 pre-osteoblasts: Psychosine elicits release of calcium from intracellular stores","volume":"214","author":"Liu","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/bbrc.2000.2905_RF26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1996.0534","article-title":"Bradykinin increases ceramide and sphingosine content in human fibroblasts: possible involvement of glycosphingolipids","volume":"221","author":"Meacci","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/bbrc.2000.2905_RF27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification","volume":"37","author":"Bligh","year":"1959","journal-title":"Can. J. Biochem. Physiol."},{"key":"10.1006\/bbrc.2000.2905_RF28","first-page":"E599","article-title":"1,25(OH)2D3 enhances PTH-induced Ca2+ transients in preosteoblasts by activating l-type Ca2+ channels","volume":"273","author":"Li","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1006\/bbrc.2000.2905_RF29","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0955-0674(96)80061-5","article-title":"Signal transduction through lipid second messengers","volume":"8","author":"Spiegel","year":"1996","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1006\/bbrc.2000.2905_RF30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0143-4160(86)90026-6","article-title":"A model for receptor-regulated calcium entry","volume":"7","author":"Putney","year":"1986","journal-title":"Cell Calcium"},{"key":"10.1006\/bbrc.2000.2905_RF31","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1002\/jbmr.5650100506","article-title":"Inhibitors of ER Ca2+-ATPase activity deplete the ATP- and thrombin-sensitive Ca2+ pool in UMR 106-01 osteosarcoma cells","volume":"10","author":"Meszaros","year":"1995","journal-title":"J. Bone Miner. Res."},{"key":"10.1006\/bbrc.2000.2905_RF32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0005-2760(98)00145-3","article-title":"The role of ceramide in cell signaling","volume":"1436","author":"Perry","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/bbrc.2000.2905_RF33","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2643164","article-title":"Functions of sphingolipids and sphingolipid breakdown products in cellular regulation","volume":"243","author":"Hannun","year":"1989","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.2905_RF34","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.2163543","article-title":"Intracellular calcium release mediated by sphingosine derivatives generated in cells","volume":"248","author":"Ghosh","year":"1990","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.2905_RF35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0174-173X(87)80036-5","article-title":"1,25-Dihydroxyvitamin D3 regulates the biosynthesis of osteopontin, a bone-derived cell attachment protein, in clonal osteoblast-like osteosarcoma cells","volume":"7","author":"Prince","year":"1987","journal-title":"Coll. Relat. Res."},{"key":"10.1006\/bbrc.2000.2905_RF36","doi-asserted-by":"crossref","first-page":"11660","DOI":"10.1016\/S0021-9258(19)70182-3","article-title":"1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cells","volume":"255","author":"Price","year":"1980","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF37","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/BF02555007","article-title":"Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells","volume":"46","author":"Fraser","year":"1990","journal-title":"Calcif. Tissue Int."},{"key":"10.1006\/bbrc.2000.2905_RF38","doi-asserted-by":"crossref","first-page":"10009","DOI":"10.1073\/pnas.88.22.10009","article-title":"Characterization of a ceramide-activated protein kinase: Stimulation by tumor necrosis factor alpha","volume":"88","author":"Mathias","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/bbrc.2000.2905_RF39","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1016\/S0021-9258(18)82288-8","article-title":"Ceramide activates heterotrimeric protein phosphatase 2A","volume":"268","author":"Dobrowsky","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.2905_RF40","doi-asserted-by":"crossref","first-page":"19200","DOI":"10.1016\/S0021-9258(17)32152-X","article-title":"Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase","volume":"269","author":"Lozano","year":"1994","journal-title":"J. Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X0092905X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X0092905X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T04:52:36Z","timestamp":1620017556000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X0092905X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,6]]}},"alternative-id":["S0006291X0092905X"],"URL":"https:\/\/doi.org\/10.1006\/bbrc.2000.2905","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,6]]}}}