{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:00:48Z","timestamp":1791306048628,"version":"4.3.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2001,1]]},"DOI":"10.1006\/bbrc.2000.4068","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T14:49:19Z","timestamp":1032187759000},"page":"32-38","source":"Crossref","is-referenced-by-count":53,"title":["Expression Profiles of BRCA1 Splice Variants in Asynchronous and in G1\/S Synchronized Tumor Cell Lines"],"prefix":"10.1006","volume":"280","author":[{"given":"Tamas I.","family":"Orban","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Olah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/bbrc.2000.4068_RF1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.7545954","article-title":"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1","volume":"266","author":"Miki","year":"1994","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.4068_RF2","unstructured":"Breast Cancer Information Core (BIC), http:\/\/www.nhgri.nih. gov\/Intramural_research\/Lab_transfer\/Bic."},{"key":"10.1006\/bbrc.2000.4068_RF3","first-page":"1242","article-title":"Analysis of BRCA1 and BRCA2 mutations in Hungarian families with breast and breast-ovarian cancer","volume":"60","author":"Ramus","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1006\/bbrc.2000.4068_RF4","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/ng0197-14","article-title":"A breast\/ovarian cancer patient with germline mutations in both BRCA1 and BRCA2","volume":"15","author":"Ramus","year":"1997","journal-title":"Nature Genet."},{"key":"10.1006\/bbrc.2000.4068_RF5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/(SICI)1098-1004(1999)14:1<92::AID-HUMU23>3.0.CO;2-2","article-title":"Strong founder effects in BRCA1 mutation carrier breast cancer patients from Latvia","volume":"14","author":"Csokay","year":"1999","journal-title":"Hum. Mut. Mutation in Brief #258 Online"},{"key":"10.1006\/bbrc.2000.4068_RF6","first-page":"1435","article-title":"Germline mutation analysis of BRCA1 and BRCA2 genes in Yugoslav breast\/ovarian cancer families","volume":"6","author":"Papp","year":"1999","journal-title":"Oncol. Rep."},{"key":"10.1006\/bbrc.2000.4068_RF7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1155\/1999\/257257","article-title":"Molecular cancer genetics in eastern and central Europe","volume":"15","author":"Olah","year":"1999","journal-title":"Dis. Markers"},{"key":"10.1006\/bbrc.2000.4068_RF8","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/(SICI)1098-1004(200005)15:5<480::AID-HUMU13>3.0.CO;2-G","article-title":"Founder BRCA1 mutations and two novel germline BRCA2 mutations in breast and\/or ovarian cancer families from North-Eastern Poland","volume":"15","author":"van der Looij","year":"2000","journal-title":"Hum. Mut. Mutation in Brief #320 Online"},{"key":"10.1006\/bbrc.2000.4068_RF9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/ng0495-439","article-title":"Somatic mutations in the BRCA1 gene in sporadic ovarian tumours","volume":"9","author":"Merajver","year":"1995","journal-title":"Nature Genet."},{"key":"10.1006\/bbrc.2000.4068_RF10","first-page":"2433","article-title":"Frequency of germline and somatic BRCA1 mutations in ovarian cancer","volume":"4","author":"Berchuck","year":"1998","journal-title":"Clin. Cancer Res."},{"key":"10.1006\/bbrc.2000.4068_RF11","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1038\/sj.onc.1202847","article-title":"Somatic mutations in the BRCA1 gene in Chinese sporadic breast and ovarian cancer","volume":"18","author":"Khoo","year":"1999","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/(SICI)1098-2264(200003)27:3<295::AID-GCC10>3.0.CO;2-F","article-title":"A sporadic breast tumor with a somatically acquired complex genomic rearrangement in BRCA1","volume":"27","author":"van der Looij","year":"2000","journal-title":"Gene. Chrom. Cancer"},{"key":"10.1006\/bbrc.2000.4068_RF13","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/ng0495-444","article-title":"Decreased expression of BRCA1 accelerates growth and is often present during sporadic breat cancer progression","volume":"9","author":"Thompson","year":"1995","journal-title":"Nature Genet."},{"key":"10.1006\/bbrc.2000.4068_RF14","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1038\/sj.onc.1202248","article-title":"Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region","volume":"17","author":"Magdinier","year":"1998","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF15","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/sj.onc.1202086","article-title":"Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells","volume":"17","author":"Rice","year":"1998","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF16","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1038\/sj.onc.1203072","article-title":"The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells","volume":"18","author":"Budhram-Mahadeo","year":"1999","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF17","first-page":"3168","article-title":"BRCA1 is a 220-Da nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner","volume":"56","author":"Chen","year":"1996","journal-title":"Cancer Res."},{"key":"10.1006\/bbrc.2000.4068_RF18","first-page":"717","article-title":"Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells","volume":"7","author":"Gudas","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1006\/bbrc.2000.4068_RF19","first-page":"711","article-title":"BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells","volume":"7","author":"Vaughn","year":"1996","journal-title":"Cell Growth Differ."},{"key":"10.1006\/bbrc.2000.4068_RF20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0092-8674(77)90180-5","article-title":"An amazing sequence arrangement at the 5\u2032 ends of adenovirus 2 messenger RNA","volume":"12","author":"Chow","year":"1977","journal-title":"Cell"},{"key":"10.1006\/bbrc.2000.4068_RF21","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1043-2760(97)00167-7","article-title":"Alternative splicing of mRNA as a mode of endocrine regulation","volume":"8","author":"Chew","year":"1998","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1006\/bbrc.2000.4068_RF22","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.genet.32.1.279","article-title":"Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation","volume":"32","author":"Lopez","year":"1998","journal-title":"Annu. Rev. Genet."},{"key":"10.1006\/bbrc.2000.4068_RF23","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1101\/gr.9.12.1288","article-title":"Frequent alternative splicing of human genes","volume":"9","author":"Mironov","year":"1999","journal-title":"Genome Res."},{"key":"10.1006\/bbrc.2000.4068_RF24","first-page":"4578","article-title":"Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells","volume":"56","author":"Lu","year":"1996","journal-title":"Cancer Res."},{"key":"10.1006\/bbrc.2000.4068_RF25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/MCB.17.1.444","article-title":"Localization of BRCA1 and a splice variant identifies the nuclear localization signal","volume":"17","author":"Thakur","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/bbrc.2000.4068_RF26","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/(SICI)1098-2264(199702)18:2<102::AID-GCC4>3.0.CO;2-6","article-title":"Mutations and alternative splicing of the BRCA1 gene in UK breast\/ovarian cancer families","volume":"18","author":"Xu","year":"1997","journal-title":"Gene Chrom. Cancer"},{"key":"10.1006\/bbrc.2000.4068_RF27","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/bbrc.2000.3100","article-title":"Real-time PCR quantification of full-length and exon 11 spliced BRCA1 transcripts in human breast cancer cell lines","volume":"274","author":"Favy","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/bbrc.2000.4068_RF28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1200924","article-title":"Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b","volume":"14","author":"Wilson","year":"1997","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF29","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1128\/MCB.14.3.1698","article-title":"Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells","volume":"14","author":"Kulesz-Martin","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/bbrc.2000.4068_RF30","doi-asserted-by":"crossref","first-page":"11456","DOI":"10.1073\/pnas.94.21.11456","article-title":"Functional association between promoter structure and transcript alternative splicing","volume":"94","author":"Cramer","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/bbrc.2000.4068_RF31","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1006\/bbrc.2000.4068_RF32","first-page":"1175","article-title":"Expression of estrogen receptor \u03b11, \u03b12, and \u03b15 messenger RNAs in human breast tissue","volume":"59","author":"Leygue","year":"1999","journal-title":"Cancer Res."},{"key":"10.1006\/bbrc.2000.4068_RF33","doi-asserted-by":"crossref","first-page":"28630","DOI":"10.1074\/jbc.271.45.28630","article-title":"Subcellular localization and analysis of apparent 180-kDa and 220-kDa proteins of the breast cancer susceptibility gene, BRCA1","volume":"271","author":"Thomas","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2000.4068_RF34","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.onc.1201252","article-title":"BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases","volume":"15","author":"Wang","year":"1997","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF35","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0092-8674(00)81302-1","article-title":"The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse","volume":"85","author":"Hakem","year":"1996","journal-title":"Cell"},{"key":"10.1006\/bbrc.2000.4068_RF36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1097-4652(199912)181:3<385::AID-JCP2>3.0.CO;2-4","article-title":"Emerging roles of BRCA1 in transcriptional regulation and DNA repair","volume":"181","author":"Chen","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"10.1006\/bbrc.2000.4068_RF37","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1038\/sj.onc.1203334","article-title":"BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene","volume":"18","author":"Snouwaert","year":"1999","journal-title":"Oncogene"},{"key":"10.1006\/bbrc.2000.4068_RF38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81847-4","article-title":"Association of BRCA1 with Rad51 in mitotic and meiotic cells","volume":"88","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1006\/bbrc.2000.4068_RF39","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.286.5442.1162","article-title":"Requirement of ATM-dependent phosphorylation of Brca1 in the DNA damage response to double-strand breaks","volume":"286","author":"Cortez","year":"1999","journal-title":"Science"},{"key":"10.1006\/bbrc.2000.4068_RF40","doi-asserted-by":"crossref","first-page":"4843","DOI":"10.1128\/MCB.19.7.4843","article-title":"BRCA1 is phosphorylated at serine 1497 in vivo at a cyclin-dependent kinase 2 phosphorylation site","volume":"19","author":"Ruffner","year":"1999","journal-title":"Mol. Cell. Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X00940683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X00940683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T08:56:59Z","timestamp":1557305819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X00940683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,1]]}},"alternative-id":["S0006291X00940683"],"URL":"https:\/\/doi.org\/10.1006\/bbrc.2000.4068","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,1]]}}}