{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:30:55Z","timestamp":1760851855531},"reference-count":21,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/bbrc.2001.4265","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T13:50:03Z","timestamp":1032184203000},"page":"1251-1257","source":"Crossref","is-referenced-by-count":15,"title":["Heparan N-Sulfatase: In Vitro Mutagenesis of Potential N-Glycosylation Sites"],"prefix":"10.1006","volume":"280","author":[{"given":"Paola","family":"Di Natale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borghina","family":"Vanacore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Daniele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/bbrc.2001.4265_RF1","series-title":"The Metabolic and Molecular Bases of Inherited Disease","first-page":"2645","article-title":"The mucopolysaccharidoses","author":"Neufeld","year":"1995"},{"key":"10.1006\/bbrc.2001.4265_RF2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/ng1295-465","article-title":"Cloning of the sulfamidase gene and identification of mutations in Sanfilippo A syndrome","volume":"11","author":"Scott","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1006\/bbrc.2001.4265_RF3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/dnares\/3.4.269","article-title":"Structure and sequence of the human sulphamidase gene","volume":"3","author":"Karageorgos","year":"1996","journal-title":"DNA Res."},{"key":"10.1006\/bbrc.2001.4265_RF4","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1093\/hmg\/6.9.1573","article-title":"Novel mutations in Sanfilippo A syndrome: Implications for enzyme function","volume":"6","author":"Weber","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/bbrc.2001.4265_RF5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/(SICI)1098-1004(1997)10:6<479::AID-HUMU10>3.0.CO;2-X","article-title":"Identification of 16 sulfamidase gene mutations including the common R74C in patients with mucopolysaccharidosis type IIIA (Sanfilippo A)","volume":"10","author":"Bunge","year":"1997","journal-title":"Hum. Mutat."},{"key":"10.1006\/bbrc.2001.4265_RF6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1098-1004(1998)11:4<313::AID-HUMU9>3.0.CO;2-P","article-title":"Identification of molecular defects in Italian Sanfilippo A patients including 13 novel mutations","volume":"11","author":"Di Natale","year":"1998","journal-title":"Hum. Mutat."},{"key":"10.1006\/bbrc.2001.4265_RF7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4439(99)00118-0","article-title":"Heparan N-sulfatase gene: Two novel mutations and transient expression of fifteen defects","volume":"1501","author":"Esposito","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/bbrc.2001.4265_RF8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1042\/bj2340083","article-title":"Human liver sulphamate sulphohydrolase","volume":"234","author":"Freeman","year":"1986","journal-title":"Biochem. J."},{"key":"10.1006\/bbrc.2001.4265_RF9","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1042\/bj3290145","article-title":"Recombinant human sulphamidase: Expression, amplification, purification and characterization","volume":"329","author":"Bielicki","year":"1998","journal-title":"Biochem. J."},{"key":"10.1006\/bbrc.2001.4265_RF10","doi-asserted-by":"crossref","first-page":"37193","DOI":"10.1074\/jbc.274.52.37193","article-title":"Expression and characterization of wild type and mutant recombinant human sulfamidase. Implication for Sanfilippo (mucopolysaccharidosis IIIA) syndrome","volume":"274","author":"Perkins","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.biochem.55.1.167","article-title":"Lysosomal enzymes and their receptors","volume":"55","author":"Von Figura","year":"1986","journal-title":"Annu. Rev. Biochem."},{"key":"10.1006\/bbrc.2001.4265_RF13","doi-asserted-by":"crossref","first-page":"13262","DOI":"10.1016\/S0021-9258(18)42204-1","article-title":"In vitro mutagenesis of potential N-glycosylation sites of arylsulfatase A","volume":"267","author":"Gieselmann","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF14","doi-asserted-by":"crossref","first-page":"8808","DOI":"10.1074\/jbc.272.13.8808","article-title":"Abnormal glycosylation of procathepsin L due to N-terminal point mutations correlates with failure to sort to lysosomes","volume":"272","author":"Chapman","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI112262","article-title":"Trafficking of lysosomal enzymes in normal and disease states","volume":"77","author":"Kornfeld","year":"1986","journal-title":"J. Clin. Invest."},{"key":"10.1006\/bbrc.2001.4265_RF16","doi-asserted-by":"crossref","first-page":"23586","DOI":"10.1016\/S0021-9258(18)54323-4","article-title":"Mannose 6-phosphate-independent targeting of cathepsin D to lysosomes in HepG2 cells","volume":"266","author":"Rijnboutt","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF17","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1042\/bj2890681","article-title":"Human lysosomal \u03b1-glucosidase: Functional characterization of the glycosylation sites","volume":"289","author":"Hermans","year":"1993","journal-title":"Biochem. J."},{"key":"10.1006\/bbrc.2001.4265_RF18","doi-asserted-by":"crossref","first-page":"12193","DOI":"10.1016\/S0021-9258(19)50325-8","article-title":"The role of glycosylation and phosphorylation in the expression of active human \u03b2-glucuronidase","volume":"268","author":"Shipley","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF19","doi-asserted-by":"crossref","first-page":"10039","DOI":"10.1016\/S0021-9258(19)50196-X","article-title":"Analysis of the glycosylation and phosphorylation of the \u03b1-subunit of the lysosomal enzyme, \u03b2-hexosaminidase A, by site-directed mutagenesis","volume":"267","author":"Weits","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2001.4265_RF20","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1042\/bj3260243","article-title":"Characterization of iduronate sulphatase mutants affecting N-glycosylation sites and the cysteine 84 residue","volume":"326","author":"Millat","year":"1997","journal-title":"Biochem. J."},{"key":"10.1006\/bbrc.2001.4265_RF21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(90)90161-7","article-title":"Generation of a lysosomal enzyme targeting signal in the secretory protein pepsinogen","volume":"63","author":"Baranski","year":"1990","journal-title":"Cell"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X01942652?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X01942652?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:00:23Z","timestamp":1620018023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X01942652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0006291X01942652"],"URL":"https:\/\/doi.org\/10.1006\/bbrc.2001.4265","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}