{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:50:48Z","timestamp":1790913048048,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1006\/bbrc.2002.6683","type":"journal-article","created":{"date-parts":[[2003,4,24]],"date-time":"2003-04-24T17:03:32Z","timestamp":1051203812000},"page":"492-497","source":"Crossref","is-referenced-by-count":178,"title":["Identification of a Defect in the UGT1A1 Gene Promoter and Its Association with Hyperbilirubinemia"],"prefix":"10.1006","volume":"292","author":[{"given":"Junko","family":"Sugatani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasumi","family":"Yamakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouich","family":"Yoshinari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatomo","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Kakizaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sueyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Negishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/bbrc.2002.6683_RF1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1042\/bj1200311","article-title":"Isolation and properties of conjugated bilirubin and bile","volume":"120","author":"Ostrow","year":"1970","journal-title":"Biochem. J."},{"key":"10.1006\/bbrc.2002.6683_RF2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0021-9258(17)35280-8","article-title":"Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNA with expression in COS 1 cell","volume":"266","author":"Ritter","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/bbrc.2002.6683_RF3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00008571-199708000-00001","article-title":"The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence","volume":"7","author":"Mackenzie","year":"1997","journal-title":"Pharmacogenetics"},{"key":"10.1006\/bbrc.2002.6683_RF4","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","article-title":"The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome","volume":"333","author":"Bosma","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/bbrc.2002.6683_RF5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(96)91273-8","article-title":"Genetic variation in bilirubin UPD-glucuronosyltransferase gene promoter and Gilbert's syndrome","volume":"347","author":"Monaghan","year":"1996","journal-title":"Lancet"},{"key":"10.1006\/bbrc.2002.6683_RF6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0022-3476(99)70201-5","article-title":"Gilbert's syndrome is a contributory factor in prolonged unconjugated hyperbilirubinemia of the newborn","volume":"134","author":"Monaghan","year":"1999","journal-title":"J. Pediatr."},{"key":"10.1006\/bbrc.2002.6683_RF7","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(95)90702-5","article-title":"Analysis of genes for bilirubin UDP-glucuronosyltransferase in Gilbert's syndrome","volume":"345","author":"Aono","year":"1995","journal-title":"Lancet"},{"key":"10.1006\/bbrc.2002.6683_RF8","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1542\/peds.106.5.e59","article-title":"Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene","volume":"106","author":"Maruo","year":"2000","journal-title":"Pediatrics"},{"key":"10.1006\/bbrc.2002.6683_RF9","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1542\/peds.103.6.1224","article-title":"Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism","volume":"103","author":"Maruo","year":"1999","journal-title":"Pediatrics"},{"key":"10.1006\/bbrc.2002.6683_RF10","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0168-8278(00)80268-8","article-title":"Association of human liver bilirubin UDP-glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene","volume":"33","author":"Raijmakers","year":"2000","journal-title":"J. Hepatol."},{"key":"10.1006\/bbrc.2002.6683_RF11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0925-4439(98)00013-1","article-title":"Contribution of two missense mutations (G71R and Y486D) of the bilirubin UDP glycosyltransferase (UGT1A1) gene to phenotypes of Gilbert's syndrome and Crigler\u2013Najjar syndrome type II","volume":"1406","author":"Yamamoto","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/bbrc.2002.6683_RF12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0009-8981(97)00167-8","article-title":"Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias","volume":"266","author":"Clarke","year":"1997","journal-title":"Clin. Chim. Acta"},{"key":"10.1006\/bbrc.2002.6683_RF13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0378-4274(99)00209-X","article-title":"Drug-mediated toxicity caused by genetic deficiency of UDP-glucuronosyltransferases","volume":"112\u2013113","author":"Burchell","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1006\/bbrc.2002.6683_RF14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/1098-1004(200010)16:4<297::AID-HUMU2>3.0.CO;2-Z","article-title":"Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler\u2013Najjar and Gilbert syndromes: Correlation of genotype to phenotype","volume":"16","author":"Kadakol","year":"2000","journal-title":"Hum. Mut."},{"key":"10.1006\/bbrc.2002.6683_RF15","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1056\/NEJM196906052802303","article-title":"Hepatic bilirubin UDP-glucuronyl transferase activity in liver disease and gilbert's syndrome","volume":"280","author":"Black","year":"1969","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/bbrc.2002.6683_RF16","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/BF02776002","article-title":"Hepatic bilirubin-conjugating enzymes of man in the normal state and in liver disease","volume":"17","author":"Adachi","year":"1982","journal-title":"Gastroenterol. Jpn."},{"key":"10.1006\/bbrc.2002.6683_RF17","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1053\/jhep.2001.24172","article-title":"The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR","volume":"33","author":"Sugatani","year":"2001","journal-title":"Hepatology"},{"key":"10.1006\/bbrc.2002.6683_RF18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0925-4439(98)00030-1","article-title":"Coding defect and a TATA box mutation at the bilirubin UDP-glucuronosyltransferase gene cause Crigler\u2013Najjar type I disease","volume":"1407","author":"Ciotti","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/bbrc.2002.6683_RF19","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1203\/00006450-199406000-00002","article-title":"A new type of defect in the gene for bilirubin uridine 5\u2032-diphosphate-glucuronosyltransferase in a patient with Crigler\u2013Najjar syndrome type I","volume":"35","author":"Aono","year":"1994","journal-title":"Pediatr. Res."},{"key":"10.1006\/bbrc.2002.6683_RF20","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF02137719","article-title":"Ethanol increases liver uridine-diphosphate-glucuronyltransferase","volume":"27","author":"Ideo","year":"1971","journal-title":"Experientia"},{"key":"10.1006\/bbrc.2002.6683_RF21","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3181\/00379727-144-37603","article-title":"Effect of low caloric diet on endogenous carbon monoxide production: Normal adults and Gilbert's syndrome","volume":"144","author":"Bensinger","year":"1973","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1006\/bbrc.2002.6683_RF22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/00365517209080280","article-title":"Enhancement of heme catabolism by caloric restriction in man","volume":"30","author":"Lundh","year":"1972","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1006\/bbrc.2002.6683_RF23","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1172\/JCI117604","article-title":"Discrimination between Crigler\u2013Najjar type I and II by expression of mutant bilirubin uridine diphosphate-glucuronosyltransferase","volume":"94","author":"Seppen","year":"1994","journal-title":"J. Clin. Invest."},{"key":"10.1006\/bbrc.2002.6683_RF24","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/bbrc.1999.0453","article-title":"Glucuronidation of 7-ethyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltransferases encoded at the UGT1 locus","volume":"260","author":"Ciotti","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X02966830?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X02966830?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:36:45Z","timestamp":1620020205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X02966830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,3]]}},"alternative-id":["S0006291X02966830"],"URL":"https:\/\/doi.org\/10.1006\/bbrc.2002.6683","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,3]]}}}