{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:58:11Z","timestamp":1786978691505,"version":"build-2736575974"},"reference-count":58,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[1997,4]]},"DOI":"10.1006\/bcmd.1997.0124","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T20:07:46Z","timestamp":1033934866000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Molecular Genetics of Glucose-6-Phosphate Dehydrogenase Deficiency in Mexico"],"prefix":"10.1006","volume":"23","author":[{"given":"Maria Dolores","family":"Medina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Vaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Lopez-Guido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beryl","family":"Westwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernest","family":"Beutler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/bcmd.1997.0124_MD970124RF1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00005792-198809000-00003","article-title":"Genetic variation of glucose-6-phosphate dehydrogenase: a catalog and future prospects","volume":"67","author":"Beutler","year":"1988","journal-title":"Medicine"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF2","series-title":"Hematology","article-title":"Glucose-6-phosphate dehydrogenase deficiency and other enzyme abnormalities","author":"Beutler","year":"1995"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF3","series-title":"The Metabolic and Molecular Basis of Inherited Disease","first-page":"3398","article-title":"Glucose-6-phosphate dehydrogenase deficiency","author":"Luzzatto","year":"1995"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0268-960X(96)90019-3","article-title":"G-6-PD: Population genetics and clinical manifestations","volume":"10","author":"Beutler","year":"1996","journal-title":"Blood Reviews"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/bcmd.1996.0008","article-title":"Hematologically important mutations: Glucose-6-phosphate dehydro-genase","volume":"22","author":"Beutler","year":"1996","journal-title":"Blood Cells Mol Dis"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF6","first-page":"735","article-title":"An extensive search for RFLP in the human glucose-6-phosphate dehydrogenase locus has revealed a silent mutation in the coding sequence","volume":"42","author":"D'Urso","year":"1988","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF7","first-page":"1008","article-title":"The NT 1311 polymorphism of G6PD: G6PD Mediterranean mutation may have originated independently in Europe and Asia","volume":"47","author":"Beutler","year":"1990","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF8","first-page":"1013","article-title":"Origin and spread of the glucose-6-phosphate dehydrogenase variant (G6PD Mediterranean) in the Middle East","volume":"47","author":"Kurdi-Haidar","year":"1990","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF9","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.1073\/pnas.88.19.8568","article-title":"Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-","volume":"88","author":"Vulliamy","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/BF00219170","article-title":"A new polymorphic site in the G6PD gene","volume":"89","author":"Beutler","year":"1992","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF00276317","article-title":"Linkage between a Pvu II restriction fragment length polymorphism and G-6-PD A-202A\/37G\u2212","volume":"85","author":"Beutler","year":"1990","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF12","first-page":"394","article-title":"The origin of glucose-6-phosphate dehydrogenase (G-6-PD) polymorphisms in African-Americans","volume":"50","author":"Kay","year":"1992","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF13","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/geno.1993.1276","article-title":"G6PD haplotypes spanning Xq28 from F8C to red\/green color vision","volume":"17","author":"Filosa","year":"1993","journal-title":"Genomics"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/0140-6736(92)90653-K","article-title":"Studying X inactivation","volume":"339","author":"Curnutte","year":"1992","journal-title":"Lancet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1182\/blood.V81.1.269.269","article-title":"Transcriptional analysis of the active X-chromosome in normal and clonal hematopoiesis","volume":"81","author":"Prchal","year":"1993","journal-title":"Blood"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF16","first-page":"45","article-title":"Estudios sobre algunas caracteristicas geneticas hematologicas de la costa chica de Oaxaca y Guerrero","volume":"7","author":"Lisker","year":"1965","journal-title":"Salud Pub (Mex)"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF17","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/ajpa.1330300304","article-title":"Studies on several genetic hematological traits of the Mexican population. XVI. Hemoglobin S and G6PD deficiency in the East Coast","volume":"30","author":"Lisker","year":"1969","journal-title":"Am J Phys Anthrop"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF18","first-page":"454","article-title":"Aspectos hereditarios y epidemiologicos de la deficiencia de glucosa-6-fosfato deshidrogenasa eritrocitica en Mexico","volume":"111","author":"Lisker","year":"1976","journal-title":"Gac Med Mex"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF19","first-page":"255","article-title":"Screening for inborn errors of the erythrocyte metabolism in Northwestern Mexico","volume":"6","author":"Vaca","year":"1982","journal-title":"Acta Anthrop"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF20","first-page":"157","article-title":"Frequency and origin of G-6-PD deficiency among icteric newborns in the metropolitan area of Monterrey, Nuevo Leon, Mexico","volume":"8","author":"Gonzalez-Quiroga","year":"1994","journal-title":"Gene Geography"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF21","article-title":"Standardization of procedures for the study of glucose-6-phosphate dehydrogenase. Report of a WHO scientific group","author":"Betke","year":"1967","journal-title":"WHO Tech Rep Ser No. 366"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF22","first-page":"788","article-title":"Glucose-6-phosphate dehydrogenase Mexico. A new variant with enzyme deficiency, abnormal mobility and absence of hemolysis","volume":"79","author":"Lisker","year":"1972","journal-title":"J Lab Clin Med"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/BF00396481","article-title":"A variant glucose-6-phosphate dehydrogenase Gd (-) Chiapas associated with moderate enzyme deficiency and occasional hemolytic anemia","volume":"43","author":"Lisker","year":"1978","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF24","first-page":"754","article-title":"A glucose-6-phosphate dehydrogenase Gd (-) Castilla variant characterized by mild deficiency associated with drug induced hemolytic anemia","volume":"90","author":"Lisker","year":"1977","journal-title":"J Lab Clin Med"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00295523","article-title":"A new glucose-6-phosphate dehydrogenase variant, Gd (-) Tepic, characterized by moderate enzyme deficiency and mild episodes of hemolytic anemia","volume":"69","author":"Lisker","year":"1985","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF26","first-page":"209","article-title":"Glucosa-6-fosfato deshidrogenasa Gd (-) Distrito Federal. Nueva variante asociada a deficiencia enzimatica moderada y anemia hemolitica ocasional","volume":"33","author":"Lisker","year":"1981","journal-title":"Rev Invest Clin"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00274214","article-title":"G6PD Guadalajara. A new mutant associated with chronic nonspherocytic hemolytic anemia","volume":"61","author":"Vaca","year":"1982","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/BF00295674","article-title":"G-6-PD Jalisco and G-6-PD Morelia: two new Mexican variants","volume":"71","author":"Vaca","year":"1985","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF29","first-page":"259","article-title":"Glucose-6-phosphate dehydrogenase deficiency and abnormal hemoglobins in Mexican newborns with jaundice","volume":"33","author":"Vaca","year":"1981","journal-title":"Rev Invest Clin"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF30","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF00201837","article-title":"Some Mexican glucose-6-phosphate dehydrogenase variants revisited","volume":"86","author":"Beutler","year":"1991","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1182\/blood.V80.1.255.255","article-title":"New glucose-6-phosphate dehydrogenase (G-6-PD) mutations from various ethnic groups","volume":"80","author":"Beutler","year":"1992","journal-title":"Blood"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF32","first-page":"111","article-title":"Molecular heterogeneity of G-6-PD deficiency in Mexico","volume":"26","author":"Medina","year":"1995","journal-title":"Arch Med Res"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF33","series-title":"Red Cell Metabolism. A Manual of Biochemical Methods","author":"Beutler","year":"1975"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF34","first-page":"531","article-title":"Cellulose acetate electrophoresis of human glucose-6-phosphate dehydrogenase","volume":"73","author":"Sparkes","year":"1969","journal-title":"J Lab Clin Med"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF35","series-title":"Molecular cloning: a laboratory manual","author":"Sambrook","year":"1989"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF36","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1182\/blood.V74.7.2550.bloodjournal7472550","article-title":"Molecular heterogeneity of glucose-6-phosphate dehydrogenase A-","volume":"74","author":"Beutler","year":"1989","journal-title":"Blood"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/blood.V85.1.257.bloodjournal851257","article-title":"Glucose-6-phosphate dehydrogenase mutations and haplotypes in various ethnic groups","volume":"85","author":"Xu","year":"1995","journal-title":"Blood"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF38","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/BF00211017","article-title":"At least five polymorphic mutants account for the prevalence of glucose-6-phosphate dehydrogenase deficiency in Algeria","volume":"94","author":"Nafa","year":"1994","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF39","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1007\/BF00197169","article-title":"Mutation analysis of glucose-6-phosphate dehydro-genase (G6PD) variants in Costa Rica","volume":"87","author":"Beutler","year":"1991","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF40","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF00210598","article-title":"G-6-PD Ferrara I has the same two mutations as G-6-PD A-","volume":"93","author":"Capellini","year":"1994","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF41","first-page":"234a","article-title":"Diverse point mutations of glucose-6-phosphate dehydrogenase (G-6-PD) gene in Spanish and Cuban patients with hemolytic anemia","volume":"46","author":"Vives-Corrons","year":"1994","journal-title":"Rev Invest Clin"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF42","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1073\/pnas.85.11.3951","article-title":"Molecular cloning and nucleotide sequence of cDNA for human glucose-6-phosphate dehydrogenase variant A (-)","volume":"85","author":"Hirono","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF43","series-title":"Estructura genetica de la poblacion mexicana. Aspectos medicos y antropologicos","author":"Lisker","year":"1981"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF44","series-title":"Acerca de las migraciones centroeuropeas y mediterraneas a Iberoamerica: aspectos sociales y culturales","author":"Llorden","year":"1995"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF45","series-title":"Historia del Nuevo Mundo. Del Descubrimiento a la Conquista. La experiencia europea, 1492-1550","author":"Bernard","year":"1996"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF46","first-page":"281","article-title":"Identificacion de variantes moleculares de la enzima glucosa-6-fosfato deshidrogenasa (G-6-PD) mediante la tecnica de la reaccion en cadena de la polimerasa (PCR)","volume":"102","author":"Rovira","year":"1994","journal-title":"Medicina Clinica"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF47","first-page":"233","article-title":"Two point mutations are responsible for G-6-PD polymorphism in Sardinia","volume":"44","author":"De Vita","year":"1989","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF48","first-page":"527","article-title":"Genetic heterogeneity of glucose-6-phosphate dehydrogenase deficiency revealed by single-strand conformation and sequence analysis","volume":"52","author":"Calabro","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF49","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000154353","article-title":"Human enzyme polymorphism in the Canary Islands","volume":"46","author":"Cabrera","year":"1996","journal-title":"Hum Hered"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF50","first-page":"41","article-title":"Molecular characterization of glucose-6-phosphate dehydrogenase variants from Brazil","volume":"65","author":"Weimer","year":"1993","journal-title":"Human Biology"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF51","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1182\/blood.V83.11.3363.3363","article-title":"Molecular study of eight Japanese cases of glucose-6-phosphate dehydrogenase deficiency by non-radioisotopic single strand conformational polymorphism analysis","volume":"83","author":"Hirono","year":"1994","journal-title":"Blood"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF52","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2141.1995.tb03322.x","article-title":"Haptoglobin therapy for acute favism: a Japanese boy with Glucose-6-phosphate dehydrogenase Guadalajara","volume":"89","author":"Ogha","year":"1995","journal-title":"Brit J Haematol"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF53","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood.V85.5.1377.bloodjournal8551377","article-title":"New glucose-6-phosphate dehydrogenase mutations associated with chronic anemia","volume":"85","author":"Mason","year":"1995","journal-title":"Blood"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF54","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/BF00303006","article-title":"Heterogeneity of Mediterranean type glucose-6-phosphate dehydro-genase (G6PD) deficiency in Spain: a description of two new variants associated with favism","volume":"60","author":"Vives-Corrons","year":"1982","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF55","first-page":"149","article-title":"La biologia molecular del deficit de glucosa-6-fosfato deshidrogenasa","volume":"31","author":"Vives-Corrons","year":"1991","journal-title":"Sangre"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF56","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1093\/hmg\/3.5.833","article-title":"Glucose-6-phosphate dehydro-genase (G6PD) deficient variant G6PD Union (454 Arg\u2192Cys) has a worlwide distribution possible due to recurrent mutation","volume":"3","author":"Rovira","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF57","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1365-2141.1995.tb05246.x","article-title":"Molecular genetics of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Spain: identification of two new point mutations in the G6PD gene","volume":"91","author":"Rovira","year":"1995","journal-title":"Brit J Haematol"},{"key":"10.1006\/bcmd.1997.0124_MD970124RF58","first-page":"575","article-title":"Molecular genetics of G-6-PD Mediterranean variant and description of a new G-6-PD mutant G-6-PD Andalus1361A","volume":"47","author":"Vives-Corrons","year":"1990","journal-title":"Am J Hum Genet"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979697901248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979697901248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:19:30Z","timestamp":1761049170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979697901248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["S1079979697901248"],"URL":"https:\/\/doi.org\/10.1006\/bcmd.1997.0124","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[1997,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Genetics of Glucose-6-Phosphate Dehydrogenase Deficiency in Mexico","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/bcmd.1997.0124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1997 The Blood Cells Foundation. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}