{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:14:30Z","timestamp":1789784070440,"version":"4.0.1"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[1999,4]]},"DOI":"10.1006\/bcmd.1999.0237","type":"journal-article","created":{"date-parts":[[2002,10,7]],"date-time":"2002-10-07T14:39:06Z","timestamp":1034001546000},"page":"130-138","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"title":["T Cell Numbers Relate to Bone Involvement in Gaucher Disease"],"prefix":"10.1006","volume":"25","author":[{"given":"Lucia","family":"Lacerda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Arosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Cabeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a","family":"Porto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Amaral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fortuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"McLaren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara S\u00e1","family":"Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/bcmd.1999.0237_RF1","series-title":"The Metabolic and Molecular Bases of Inherited Disease on CD-ROM","article-title":"Gaucher disease","author":"Beutler","year":"1997"},{"key":"10.1006\/bcmd.1999.0237_RF2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1399-0004.1994.tb04034.x","article-title":"Gaucher disease: N370S glucocerebrosidase gene frequency in the Portuguese population","volume":"45","author":"Lacerda","year":"1994","journal-title":"Clin Genet"},{"key":"10.1006\/bcmd.1999.0237_RF3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0950-3536(97)80033-9","article-title":"Gaucher's disease: clinical features and natural history","volume":"10","author":"Cox","year":"1997","journal-title":"Bailli\u00e8res Clin Haematol"},{"key":"10.1006\/bcmd.1999.0237_RF4","unstructured":"Rosenthal, D. Quantitative imaging of the skeleton in patients with Gaucher disease, Gaucher Clinical Perspectives3:4\u20138, 1995."},{"key":"10.1006\/bcmd.1999.0237_RF5","unstructured":"Siffert, R, Platt, G. Gaucher disease: Orthopedic considerations. In: Desnick, R, Gatt, S, Grabowski, G, eds. Gaucher disease. A Century of Delineation and ResearchNew York, Alan R Liss, pp. 617\u2013626, 1982."},{"key":"10.1006\/bcmd.1999.0237_RF6","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199105233242104","article-title":"Replacement therapy for inherited enzyme deficiency: macrophage-targeted glucocerebrosidase for Gaucher's disease","volume":"324","author":"Barton","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1006\/bcmd.1999.0237_RF7","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/bcmd.1996.0016","article-title":"Effect of low-dose enzyme replacement therapy on bones in Gaucher disease patients with severe skeletal involvement","volume":"22","author":"Elstein","year":"1996","journal-title":"Blood Cells Mol Dis"},{"key":"10.1006\/bcmd.1999.0237_RF8","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1016\/S0140-6736(96)04451-0","article-title":"Therapeutic delivery of proteins to macrophages: implications for treatment of Gaucher's disease","volume":"348","author":"Mistry","year":"1996","journal-title":"Lancet"},{"key":"10.1006\/bcmd.1999.0237_RF9","doi-asserted-by":"crossref","unstructured":"Beutler, E, Kuhl, W, Vaughan, L, M. Failure of alglucerase infused into Gaucher disease patients to localize in marrow macrophages. Mol Med1:320\u2013324.","DOI":"10.1007\/BF03401556"},{"key":"10.1006\/bcmd.1999.0237_RF10","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1210\/endo.137.6.8641199","article-title":"A role for CD8+ T lymphocytes in osteoclast differentiation in vitro","volume":"137","author":"John","year":"1996","journal-title":"Endocrinology"},{"key":"10.1006\/bcmd.1999.0237_RF11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1172\/JCI1333","article-title":"Interleukin 18 inhibits osteoclast formation via T cell production of granulocyte macrophage colony-stimulating factor","volume":"101","author":"Horwood","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1006\/bcmd.1999.0237_RF12","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1172\/JCI117084","article-title":"Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease","volume":"93","author":"Hollak","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1006\/bcmd.1999.0237_RF13","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0950-3536(97)80034-0","article-title":"Plasma and metabolic abnormalities in Gaucher's disease","volume":"10","author":"Aerts","year":"1997","journal-title":"Bailli\u00e8res Clin Haematol"},{"key":"10.1006\/bcmd.1999.0237_RF14","doi-asserted-by":"crossref","first-page":"24684","DOI":"10.1016\/S0021-9258(18)54284-8","article-title":"Cloning, sequence, and developmental expression of type 5, tartrate-resistant, acid phosphatase of rat bone","volume":"266","author":"Ek-Rylander","year":"1991","journal-title":"J. Biol Chem"},{"key":"10.1006\/bcmd.1999.0237_RF15","doi-asserted-by":"crossref","first-page":"14853","DOI":"10.1016\/S0021-9258(17)36541-9","article-title":"Dephosphorylation of osteopondin and bone sialoprotein by osteoclastic tartrate-resistant acid-phosphatase. Modulation of osteoclast adhesion in vitro","volume":"269","author":"Ek-Rylander","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1006\/bcmd.1999.0237_RF16","doi-asserted-by":"crossref","unstructured":"S\u00e1 Miranda, M, C, Aerts, J, M, Pinto, R, et al 1990. Activity of glucocerebrosidase in extracts of different cell types from type 1 Gaucher disease patients. Clin Genet38:218\u2013227, 1990.","DOI":"10.1111\/j.1399-0004.1990.tb03573.x"},{"key":"10.1006\/bcmd.1999.0237_RF17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/bmmb.1993.1011","article-title":"Type I Gaucher disease: molecular, biochemical and clinical characterization of patients from Northern Portugal","volume":"49","author":"Amaral","year":"1993","journal-title":"Biochem Med Metab Biol"},{"key":"10.1006\/bcmd.1999.0237_RF18","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/(SICI)1098-1004(1996)8:3<280::AID-HUMU15>3.0.CO;2-Z","article-title":"Type 1 Gaucher disease: identification of N396T and prevalence of glucocerebrosidase mutations in the Portuguese","volume":"8","author":"Amaral","year":"1996","journal-title":"Hum Mutat"},{"key":"10.1006\/bcmd.1999.0237_RF19","first-page":"943","article-title":"Gaucher's disease type 1: assessment of bone involvement by CT and scintigraphy","volume":"147","author":"Hermann","year":"1986","journal-title":"Am J Rad"},{"key":"10.1006\/bcmd.1999.0237_RF20","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0140-6736(89)90536-9","article-title":"Prediction of severity of Gaucher's disease by identification of mutations at DNA level","volume":"2","author":"Zimran","year":"1989","journal-title":"Lancet"},{"key":"10.1006\/bcmd.1999.0237_RF21","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0304-4165(81)90474-8","article-title":"Uptake and distribution of placental glucocerebrosidase in rat hepatic cells and effects of sequential deglycosylation","volume":"673","author":"Furbish","year":"1981","journal-title":"Biochem. Biophys. Acta"},{"key":"10.1006\/bcmd.1999.0237_RF22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000469457","article-title":"Age dependency of serum acid phosphatase in controls and Gaucher patients","volume":"32","author":"Magalh\u00e3es","year":"1984","journal-title":"Enzyme"},{"key":"10.1006\/bcmd.1999.0237_RF23","doi-asserted-by":"crossref","unstructured":"Arosa, F, da Silva, A, Godinho, et al. 1994. Decreased CD8-p56lck activity in peripheral blood T-lymphocytes from patients with hereditary haemochromatosis. Scand J Immunol39:426\u2013432, 1994.","DOI":"10.1111\/j.1365-3083.1994.tb03396.x"},{"key":"10.1006\/bcmd.1999.0237_RF24","article-title":"Multiple linear regression and finite mixture distribution modeling for sequential analysis of hematological data","author":"McLaren","year":"1999","journal-title":"Stat Med"},{"key":"10.1006\/bcmd.1999.0237_RF25","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1080\/00401706.1974.10489231","article-title":"Regression by leaps and bounds","volume":"16","author":"Furnival","year":"1974","journal-title":"Technometrics"},{"key":"10.1006\/bcmd.1999.0237_RF26","series-title":"Spline Smoothing and Nonparametric Regression","author":"Eubanks","year":"1988"},{"key":"10.1006\/bcmd.1999.0237_RF27","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/00043426-198722000-00007","article-title":"Thymic dysfunctioning histiocytosis X","volume":"9","author":"Consolini","year":"1987","journal-title":"Am J Pediatr Hematol\/Oncol"},{"key":"10.1006\/bcmd.1999.0237_RF28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0003-9969(95)00025-K","article-title":"Reduced CD8+ peripheral blood T lymphocytes in rapidly progressive periodontitis","volume":"40","author":"Nagasawa","year":"1995","journal-title":"Arch Oral Biol"},{"key":"10.1006\/bcmd.1999.0237_RF29","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0006-291X(64)90503-0","article-title":"Characterization of the main splenic glycolipids in Gaucher's disease: Evidence for the site of metabolic block","volume":"15","author":"Philipart","year":"1964","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1006\/bcmd.1999.0237_RF30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/eji.1830200121","article-title":"Chemical residues of ganglioside molecules involved in interactions with lymphocyte surface targets leading to CD4 masking and inhibition of mitogenic proliferation","volume":"20","author":"Grassi","year":"1990","journal-title":"Eur J Immunol"},{"key":"10.1006\/bcmd.1999.0237_RF31","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/S0021-9258(18)54085-0","article-title":"Mechanism of action of the monosialoganglioside GM1 as a modulator of CD4 expression","volume":"268","author":"Saggioro","year":"1993","journal-title":"J Biol Chem"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979699902371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979699902371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:18:40Z","timestamp":1761049120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979699902371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["S1079979699902371"],"URL":"https:\/\/doi.org\/10.1006\/bcmd.1999.0237","relation":{},"ISSN":["1079-9796"],"issn-type":[{"value":"1079-9796","type":"print"}],"subject":[],"published":{"date-parts":[[1999,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T Cell Numbers Relate to Bone Involvement in Gaucher Disease","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/bcmd.1999.0237","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}