{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T13:37:18Z","timestamp":1761485838643,"version":"build-2065373602"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Cells, Molecules, and Diseases"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1006\/bcmd.2000.0280","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T10:51:07Z","timestamp":1032173467000},"page":"91-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Diminished Blood Levels of Reduced Glutathione and \u03b1-Tocopherol in Two Triosephosphate Isomerase-Deficient Brothers"],"prefix":"10.1006","volume":"26","author":[{"given":"Eszter","family":"Karg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"N\u00e9meth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margit","family":"Hor\u00e1nyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1ndor","family":"Pint\u00e9r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e9csei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Holl\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/bcmd.2000.0280_RF1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0098-2997(96)88345-2","article-title":"Hemolytic anemias due to erythrocyte enzyme deficiencies","volume":"17","author":"Jacobasch","year":"1996","journal-title":"Mol Aspects Med"},{"key":"10.1006\/bcmd.2000.0280_RF2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM196502042720503","article-title":"Hereditary hemolytic anaemia with triosephosphate isomerase deficiency","volume":"272","author":"Schneider","year":"1965","journal-title":"N Engl J Med"},{"key":"10.1006\/bcmd.2000.0280_RF3","series-title":"Hereditary Disorders of Erythrocyte Metabolism","first-page":"273","article-title":"Triosephosphate isomerase deficiency. B. Inherited triosephosphate isomerase deficiency: Erythrocyte carbohydrate metabolism and preliminary studies of the erythrocyte enzyme","author":"Schneider","year":"1968"},{"key":"10.1006\/bcmd.2000.0280_RF4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/BF00216456","article-title":"Hereditary triosephosphate isomerase (TPI) deficiency: Two severely affected brothers one with and one without neurological symptoms","volume":"92","author":"Holl\u00e1n","year":"1993","journal-title":"Hum Genet"},{"key":"10.1006\/bcmd.2000.0280_RF5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1073\/pnas.92.1.268","article-title":"Erythrocyte lipids in triose-phosphate isomerase deficiency","volume":"92","author":"Holl\u00e1n","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/bcmd.2000.0280_RF6","first-page":"1260","article-title":"Human triose-phosphate isomerase deficiency resulting from mutation of Phe-240","volume":"52","author":"Chang","year":"1993","journal-title":"Am J Hum Genet"},{"key":"10.1006\/bcmd.2000.0280_RF7","series-title":"Glutathione","first-page":"216","article-title":"Protection of membranes by glutathione","author":"Kosower","year":"1973"},{"key":"10.1006\/bcmd.2000.0280_RF8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1749-6632.1972.tb27849.x","article-title":"Functional and structural aspects of biological membranes: A suggested structural role for vitamin E in the control of membrane permeability and stability","volume":"18","author":"Lucy","year":"1972","journal-title":"Ann NY Acad Sci"},{"key":"10.1006\/bcmd.2000.0280_RF9","first-page":"11","article-title":"Interaction of tocopherols and ubiquinones with monolayers of phospholipids","volume":"161","author":"Maggio","year":"1977","journal-title":"Biochem J"},{"key":"10.1006\/bcmd.2000.0280_RF10","first-page":"563","article-title":"Membrane effects of vitamin E, cholesterol and other acetates on peroxidative susceptibility","volume":"22","author":"Gutteridge","year":"1978","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1006\/bcmd.2000.0280_RF11","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/226759a0","article-title":"Relationship between glutathione reductase activity and drug-induced haemolytic anaemia","volume":"226","author":"Beutler","year":"1970","journal-title":"Nature"},{"key":"10.1006\/bcmd.2000.0280_RF12","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1002\/ana.410360305","article-title":"Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia","volume":"36","author":"Sian","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1006\/bcmd.2000.0280_RF13","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ajcn\/12.2.99","article-title":"Erythrocyte survival time and reticulocyte levels after tocopherol depletion in man","volume":"12","author":"Horwitt","year":"1963","journal-title":"Am J Clin Nutr"},{"key":"10.1006\/bcmd.2000.0280_RF14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0140-6736(83)92598-9","article-title":"Vitamin E and neurologic function","volume":"i","author":"Muller","year":"1983","journal-title":"Lancet"},{"key":"10.1006\/bcmd.2000.0280_RF15","doi-asserted-by":"crossref","first-page":"10362","DOI":"10.1073\/pnas.94.19.10362","article-title":"Search for the pathogenesis of the differing phenotype in two compound heterozygote Hungarian brothers with the same genotypic triosephosphate isomerase deficiency","volume":"94","author":"Holl\u00e1n","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/bcmd.2000.0280_RF16","first-page":"929","article-title":"D\u00e9ficiences en enzymes glycolytiques et neurod\u00e9g\u00e9n\u00e9rescence","volume":"192","author":"Holl\u00e1n","year":"1998","journal-title":"C R Soc Biol"},{"key":"10.1006\/bcmd.2000.0280_RF17","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0076-6879(90)86118-F","article-title":"Oxidative reactions of hemoglobin","volume":"186","author":"Winterbourn","year":"1979","journal-title":"Methods Enzymol"},{"key":"10.1006\/bcmd.2000.0280_RF18","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1093\/clinchem\/39.12.2522","article-title":"Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: Importance of extraction pH and influence of sample preservation and storage","volume":"39","author":"Wasowicz","year":"1993","journal-title":"Clin Chem"},{"key":"10.1006\/bcmd.2000.0280_RF19","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/clinchem\/33.2.214","article-title":"Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde\u2013thiobarbituric acid adduct","volume":"33","author":"Wong","year":"1987","journal-title":"Clin Chem"},{"key":"10.1006\/bcmd.2000.0280_RF20","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/clinchem\/37.8.1423","article-title":"Free and bound malondialdehyde measured as thiobarbituric acid product by HPLC in serum and plasma","volume":"37","author":"Carbonneau","year":"1991","journal-title":"Clin Chem"},{"key":"10.1006\/bcmd.2000.0280_RF21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0891-5849(94)90036-1","article-title":"Blood glutathione redox ratio as a parameter of oxidative stress in premature infants with IRDS","volume":"16","author":"N\u00e9meth","year":"1994","journal-title":"Free Radical Biol Med"},{"key":"10.1006\/bcmd.2000.0280_RF22","first-page":"232","article-title":"Simultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase","volume":"61","author":"Hess","year":"1991","journal-title":"Int J Vit Nutr Res"},{"key":"10.1006\/bcmd.2000.0280_RF23","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/000456328602300505","article-title":"The use of different lipids to express serum tocopherol:lipid ratios for the measurement of vitamin E status","volume":"23","author":"Thurnham","year":"1986","journal-title":"Ann Clin Biochem"},{"key":"10.1006\/bcmd.2000.0280_RF24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1006\/abio.1993.1518","article-title":"A liquid chromatographic method for the simultaneous determination of \u03b1-tocopherol and tocopherolquinone in human red blood cells and other biological samples where tocopherol is easily oxidized during sample treatment","volume":"214","author":"Vatassery","year":"1993","journal-title":"Anal Biochem"},{"key":"10.1006\/bcmd.2000.0280_RF25","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/abio.1994.1511","article-title":"Single extraction method for the spectrophotometric quantification of oxidized and reduced pyridine nucleotides in erythrocytes","volume":"222","author":"Wagner","year":"1994","journal-title":"Anal Biochem"},{"key":"10.1006\/bcmd.2000.0280_RF26","series-title":"Methods in Enzymology","first-page":"258","article-title":"Glutathione reductase","author":"Goldberg","year":"1983"},{"key":"10.1006\/bcmd.2000.0280_RF27","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione S-transferases. The first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1006\/bcmd.2000.0280_RF28","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1042\/bj2540751","article-title":"Modification of the glyoxalase system in human red blood cells by glucose in vitro","volume":"254","author":"Thornalley","year":"1988","journal-title":"Biochem J"},{"key":"10.1006\/bcmd.2000.0280_RF29","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0003-2697(05)80004-1","article-title":"Fluorimetric assay of d-lactate","volume":"206","author":"McLellan","year":"1992","journal-title":"Anal Biochem"},{"key":"10.1006\/bcmd.2000.0280_RF30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0005-2736(86)90501-8","article-title":"Vitamin E in young and old human red blood cells","volume":"860","author":"Burton","year":"1986","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/bcmd.2000.0280_RF31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1203\/00006450-198803000-00012","article-title":"Cellular dehydration and immunoglobulin binding in senescent neonatal erythrocytes","volume":"23","author":"Lane","year":"1988","journal-title":"Pediatr Res"},{"key":"10.1006\/bcmd.2000.0280_RF32","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1093\/clinchem\/45.10.1781","article-title":"Overexpression of erythrocyte glutathione S-transferase in uremia and dialysis","volume":"45","author":"Galli","year":"1999","journal-title":"Clin Chem"},{"key":"10.1006\/bcmd.2000.0280_RF33","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/pd.1970060312","article-title":"Possibility of prenatal diagnosis of hereditary triose phosphate isomerase deficiency","volume":"6","author":"Rosa","year":"1986","journal-title":"Prenat Diag"},{"key":"10.1006\/bcmd.2000.0280_RF34","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1182\/blood.V71.2.512.512","article-title":"Decreased erythrocyte nicotinamide adenine dinucleotide redox potential and abnormal pyridine nucleotide content in sickle cell disease","volume":"71","author":"Zerez","year":"1988","journal-title":"Blood"},{"key":"10.1006\/bcmd.2000.0280_RF35","first-page":"1051","article-title":"Studies on human erythrocyte glutathione S-transferase from HbAA, HbAS and HbSS subjects","volume":"50","author":"Anosike","year":"1991","journal-title":"Biomed Biochim Acta"},{"key":"10.1006\/bcmd.2000.0280_RF36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0047-6374(91)90097-J","article-title":"Cell age dependent decay of human erythrocytes glutathione S-transferase","volume":"58","author":"Fazi","year":"1991","journal-title":"Mech Ageing Dev"},{"key":"10.1006\/bcmd.2000.0280_RF37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ajh.2830110203","article-title":"Characteristics of enzymes of erythrocytes from newborn infants and adults: Activity, thermostability, and electrophilic profile as a function of cell age","volume":"11","author":"Mohrenweiser","year":"1981","journal-title":"Am J Hematol"},{"key":"10.1006\/bcmd.2000.0280_RF38","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1042\/cs0910575","article-title":"Negative association between erythrocyte reduced glutathione concentration and diabetic complications","volume":"91","author":"Thornalley","year":"1996","journal-title":"Clin Sci"},{"key":"10.1006\/bcmd.2000.0280_RF39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1432-1033.1993.tb17638.x","article-title":"The formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal","volume":"212","author":"Phillips","year":"1993","journal-title":"Eur J Biochem"},{"key":"10.1006\/bcmd.2000.0280_RF40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0047-6374(89)90026-2","article-title":"Glyoxalase activity in human red blood cells fractioned by age","volume":"48","author":"McLellan","year":"1989","journal-title":"Mech Ageing Dev"},{"key":"10.1006\/bcmd.2000.0280_RF41","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/j.1432-1033.1988.tb14105.x","article-title":"The protection of ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E","volume":"174","author":"Wefers","year":"1988","journal-title":"Eur J Biochem"},{"key":"10.1006\/bcmd.2000.0280_RF42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/ajcn\/40.4.747","article-title":"Vitamin E is delivered to cells via a high affinity receptor for low density lipoprotein","volume":"40","author":"Traber","year":"1984","journal-title":"Am J Clin Nutr"},{"key":"10.1006\/bcmd.2000.0280_RF43","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/S0022-2275(20)37971-2","article-title":"The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue: Normal and abetalipoproteinemic subjects","volume":"24","author":"Kayden","year":"1983","journal-title":"J Lipid Res"},{"key":"10.1006\/bcmd.2000.0280_RF44","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0021-9150(94)90035-3","article-title":"Discrimination between RRR- and all-racemic-alpha-tocopherols labeled with deuterium by patients with abetalipoproteinemia","volume":"108","author":"Traber","year":"1994","journal-title":"Atherosclerosis"},{"key":"10.1006\/bcmd.2000.0280_RF45","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1096\/fasebj.10.5.8621054","article-title":"Absorption, metabolism, and transport of carotenoids","volume":"10","author":"Parker","year":"1996","journal-title":"FASEB J"},{"key":"10.1006\/bcmd.2000.0280_RF46","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/BF02538909","article-title":"\u03b2-Carotene transport in human lipoproteins. Comparisons with \u03b1-tocopherol","volume":"29","author":"Traber","year":"1994","journal-title":"Lipids"},{"key":"10.1006\/bcmd.2000.0280_RF47","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/ajcn\/67.1.81","article-title":"Effect of menstrual cycle phase on the concentration of individual carotenoids in lipoproteins of premenopausal women: A controlled dietary study","volume":"67","author":"Forman","year":"1998","journal-title":"Am J Clin Nutr"},{"key":"10.1006\/bcmd.2000.0280_RF48","first-page":"491","article-title":"Serum carotene, vitamin A, retinol-binding protein and lipoproteins before and after jejunoileal bypass surgery","volume":"6","author":"Vahlquist","year":"1982","journal-title":"Int J Obes"},{"key":"10.1006\/bcmd.2000.0280_RF49","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0003-9861(92)90658-J","article-title":"\u03b2-Carotene and \u03b1-tocopherol are synergistic antioxidants","volume":"297","author":"Palozza","year":"1992","journal-title":"Arch Biochem Biophys"},{"key":"10.1006\/bcmd.2000.0280_RF50","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0891-5849(92)90181-F","article-title":"The role of lipid peroxidation and antioxidants in oxidative modification of LDL","volume":"13","author":"Estrebauer","year":"1992","journal-title":"Free Radical Biol Med"}],"container-title":["Blood Cells, Molecules, and Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979600902808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1079979600902808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T12:19:15Z","timestamp":1761049155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1079979600902808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S1079979600902808"],"URL":"https:\/\/doi.org\/10.1006\/bcmd.2000.0280","relation":{},"ISSN":["1079-9796"],"issn-type":[{"type":"print","value":"1079-9796"}],"subject":[],"published":{"date-parts":[[2000,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diminished Blood Levels of Reduced Glutathione and \u03b1-Tocopherol in Two Triosephosphate Isomerase-Deficient Brothers","name":"articletitle","label":"Article Title"},{"value":"Blood Cells, Molecules, and Diseases","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/bcmd.2000.0280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}