{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:04:01Z","timestamp":1773385441753,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2002,8]]},"DOI":"10.1006\/brbi.2001.0632","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T10:51:08Z","timestamp":1032173468000},"page":"333-350","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Altered Expression of Autonomic Neurotransmitter Receptors and Proliferative Responses in Lymphocytes from a Chronic Mild Stress Model of Depression: Effects of Fluoxetine"],"prefix":"10.1006","volume":"16","author":[{"given":"Valeria Ayelli","family":"Edgar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graciela A.","family":"Cremaschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Sterin-Borda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Mar\u0131\u0301a","family":"Genaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/brbi.2001.0632_RF1","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1146\/annurev.pa.30.040190.003021","article-title":"Interactions between the brain and immune system","volume":"30","author":"Ader","year":"1990","journal-title":"Ann. Rev. Pharmacol. Toxicol."},{"key":"10.1006\/brbi.2001.0632_RF2","series-title":"Diagnostic and Statistical Manual for Mental Disorders, 4th ed","year":"1994"},{"key":"10.1006\/brbi.2001.0632_RF3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0014-2999(99)00142-9","article-title":"Role of protein kinase C and cAMP in fluoxetine effects on human T-cell proliferation","volume":"372","author":"Ayelli Edgar","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/brbi.2001.0632_RF4","first-page":"204","article-title":"Decreased density of \u03b2-adrenergic receptors on peripheral blood mononuclear cells in patients with rheumatoid arthritis","volume":"19","author":"Baerwald","year":"1992","journal-title":"J. Rheumatol."},{"key":"10.1006\/brbi.2001.0632_RF5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0171-2985(99)80034-5","article-title":"Reduced catecholamine response of lymphocytes from patients with rheumatoid arthritis","volume":"200","author":"Baerwald","year":"1999","journal-title":"Immunobiology"},{"key":"10.1006\/brbi.2001.0632_RF6","series-title":"The pharmacological basis of therapeutics, 9th ed.","first-page":"459","article-title":"Drugs and treatment of psychiatric disorders","author":"Baldessarini","year":"1996"},{"key":"10.1006\/brbi.2001.0632_RF7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj1210561","article-title":"A simple and sensitive saturation method for the measurement of adenosine 3\u20325\u2032-cyclic monophosphate","volume":"121","author":"Brown","year":"1971","journal-title":"Biochem. J."},{"key":"10.1006\/brbi.2001.0632_RF8","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.4049\/jimmunol.127.6.2496","article-title":"A monoclonal antibody discriminating between subsets of T and B cells","volume":"127","author":"Bruce","year":"1981","journal-title":"J. Immunol."},{"key":"10.1006\/brbi.2001.0632_RF9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0014-5793(95)00366-H","article-title":"Down-regulation of \u03b2-adrenergic receptors induced by mitogen activation of intracellular signaling events in lymphocytes","volume":"364","author":"Cazaux","year":"1995","journal-title":"FEBS. Lett."},{"key":"10.1006\/brbi.2001.0632_RF10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0006-3223(96)00058-3","article-title":"Changes in sleep architecture following chronic mild stress","volume":"41","author":"Cheeta","year":"1997","journal-title":"Biol. Psychiatr."},{"key":"10.1006\/brbi.2001.0632_RF11","first-page":"112","article-title":"Neurotransmitters, hormones and cyclic nucleotides in lymphocyte regulation","volume":"44","author":"Coffey","year":"1985","journal-title":"Fed. Proc."},{"key":"10.1006\/brbi.2001.0632_RF12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1146\/annurev.psych.47.1.113","article-title":"Health psychology: Psychological factors and physical disease from the perspective of human psychoneuroimmunology","volume":"47","author":"Cohen","year":"1996","journal-title":"Annu. Rev. Psychol."},{"key":"10.1006\/brbi.2001.0632_RF13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0162-3109(88)90002-1","article-title":"Muscarinic cholinergic binding sites on rat lymphocytes","volume":"16","author":"Costa","year":"1988","journal-title":"Immunopharmacology"},{"key":"10.1006\/brbi.2001.0632_RF14","first-page":"1350","article-title":"Moderate stress enhances, and chronic stress suppresses, cell-mediated immunity \u201cin vivo.\u201d","volume":"22","author":"Drabhar","year":"1996","journal-title":"Abstracts Soc. Neurosci."},{"key":"10.1006\/brbi.2001.0632_RF15","first-page":"213","article-title":"Changes in blood leukocyte distribution: Interactions between catecholamine and glucocorticoid hormones","volume":"6","author":"Drabhar","year":"1999","journal-title":"Neuroimmunomodulation"},{"key":"10.1006\/brbi.2001.0632_RF16","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00006842-199407000-00003","article-title":"The effects of chronic stress on \u03b2-adrenergic receptors","volume":"56","author":"Dimsdale","year":"1994","journal-title":"Psychosom. Med."},{"key":"10.1006\/brbi.2001.0632_RF17","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0898-6568(98)00016-3","article-title":"Fluoxetine action on murine T-lymphocyte proliferation","volume":"10","author":"Edgar","year":"1998","journal-title":"Cell Signal."},{"key":"10.1006\/brbi.2001.0632_RF18","series-title":"Chemical Immunology: Neuroimmunoendocrinology","first-page":"25","article-title":"Noradrenergic and peptidic innervation of lymphoid organs","author":"Felten","year":"1992"},{"key":"10.1006\/brbi.2001.0632_RF19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0024-3205(97)00329-9","article-title":"Effects of fluoxetine on the immunosupressive response to stress in mice","volume":"60","author":"Freire-Garabal","year":"1997","journal-title":"Life Sci."},{"key":"10.1006\/brbi.2001.0632_RF20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0162-3109(89)90031-3","article-title":"Alloimmunization-induced changes in \u03b2-adrenoceptor expression and cAMP on B lymphocytes","volume":"18","author":"Genaro","year":"1989","journal-title":"Immunopharmacology"},{"key":"10.1006\/brbi.2001.0632_RF21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0162-3109(93)90063-V","article-title":"Muscarinic cholinergic receptors on murine lymphocyte subpopulations","volume":"26","author":"Genaro","year":"1993","journal-title":"Immunopharmacology"},{"key":"10.1006\/brbi.2001.0632_RF22","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1037\/0033-2909.113.3.472","article-title":"Depression and immunity: A meta-analytic review","volume":"113","author":"Herbert","year":"1993","journal-title":"Psychol Bull."},{"key":"10.1006\/brbi.2001.0632_RF23","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1096\/fasebj.6.3.1740234","article-title":"Diversity of structure, signaling, and regulation within the family of muscarinic cholinergic receptors","volume":"6","author":"Hosey","year":"1992","journal-title":"FASEB J."},{"key":"10.1006\/brbi.2001.0632_RF24","series-title":"Psychopharmacology: The Fourth Generation of Progress","first-page":"983","article-title":"Psychoneuroimmunology of depression","author":"Irwin","year":"1995"},{"key":"10.1006\/brbi.2001.0632_RF25","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/eji.1830031011","article-title":"A rapid method for the isolation of functional thymus-derived murine lymphocytes","volume":"3","author":"Julius","year":"1973","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/brbi.2001.0632_RF26","first-page":"692","article-title":"Disturbed neuroendocrine-immune interactions in chronic fatigue syndrome","volume":"85","author":"Kavelaars","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/brbi.2001.0632_RF27","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00006842-199107000-00001","article-title":"Spousal caregivers of dementia victims: Longitudinal changes in immunity and health","volume":"53","author":"Kiecolt-Glaser","year":"1991","journal-title":"Psychosom. Med."},{"key":"10.1006\/brbi.2001.0632_RF28","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00006842-198709000-00008","article-title":"Chronic stress and immunity in family caregivers of Alzheimer's disease victims","volume":"49","author":"Kiecolt-Glaser","year":"1987","journal-title":"Psychosom. Med."},{"key":"10.1006\/brbi.2001.0632_RF29","first-page":"67","article-title":"The effect of MK-801 and imipramine on beta-adrenergic and 5-HT2 receptors in the chronic mild stress model of depression in rats","volume":"46","author":"Klimek","year":"1994","journal-title":"Pol. J. Pharmacol."},{"key":"10.1006\/brbi.2001.0632_RF30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0165-5728(92)90007-8","article-title":"Stress-induced changes in muscarinic and beta-adrenergic binding sites on rat thymocytes and lymphocytes","volume":"37","author":"Kubera","year":"1992","journal-title":"J. Neuroimmunol."},{"key":"10.1006\/brbi.2001.0632_RF31","first-page":"367","article-title":"Differential regulation of mouse B-cell activation by \u03b2-adrenoceptor stimulation depending on type of mitogen","volume":"69","author":"Li","year":"1990","journal-title":"Immunology"},{"key":"10.1006\/brbi.2001.0632_RF32","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1096\/fasebj.13.6.715","article-title":"Descreased expression and activity of G protein-coupled receptor kinases by peripheral blood mononuclear cells of patients with rheumatoid arthritis","volume":"13","author":"Lombardi","year":"1999","journal-title":"FASEB J."},{"key":"10.1006\/brbi.2001.0632_RF33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0278-5846(94)00101-M","article-title":"Evidence for an immune response in major depression: A review and hypothesis","volume":"19","author":"Maes","year":"1995","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiat."},{"key":"10.1006\/brbi.2001.0632_RF34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0165-5728(88)90118-X","article-title":"Muscarinic receptors and receptor-mediated actions in rat thymocytes","volume":"17","author":"Malinski","year":"1988","journal-title":"J. Neuroimmunol."},{"key":"10.1006\/brbi.2001.0632_RF35","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00006842-199705000-00008","article-title":"Plasma catecholamine and lymphocyte \u03b22-adrenergic receptor alterations in elderly Alzheimer caregivers under stress","volume":"59","author":"Mills","year":"1997","journal-title":"Psychosom Med."},{"key":"10.1006\/brbi.2001.0632_RF36","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02246218","article-title":"Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine","volume":"117","author":"Monleon","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1006\/brbi.2001.0632_RF37","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0003-2697(80)90515-1","article-title":"Ligand, a versatile computarized approach for characterization of ligand-binding systems","volume":"107","author":"Munson","year":"1980","journal-title":"Ann. Biochem."},{"key":"10.1006\/brbi.2001.0632_RF38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF02247719","article-title":"Reversal of stress-induced anhedonia by the atypical antidepressants fluoxetine and maprotiline","volume":"109","author":"Muscat","year":"1992","journal-title":"Psychopharmacology"},{"key":"10.1006\/brbi.2001.0632_RF39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00006842-199103000-00002","article-title":"Immunological changes in young and old adults during brief laboratory stress","volume":"53","author":"Neliboff","year":"1991","journal-title":"Psychosom. Med."},{"key":"10.1006\/brbi.2001.0632_RF40","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1099-1700(1998100)14:4<261::AID-SMI811>3.0.CO;2-W","article-title":"Genetic and environmental models of stress-induced depression in rats","volume":"14","author":"Overstreet","year":"1998","journal-title":"Stress Med."},{"key":"10.1006\/brbi.2001.0632_RF41","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00006842-199805000-00013","article-title":"Circulating lymphocyte subsets in major depression and dysthimia with typical or atypical features","volume":"60","author":"Ravindran","year":"1998","journal-title":"Psychosom. Med."},{"key":"10.1006\/brbi.2001.0632_RF42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-3565(25)21378-7","article-title":"Beta-adrenoceptor mediator of enhancing effect of norepinephrine on the murine primary antibody response in vitro","volume":"230","author":"Sanders","year":"1984","journal-title":"J. Pharmacol Exp. Ther."},{"key":"10.1006\/brbi.2001.0632_RF43","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.4049\/jimmunol.157.4.1514","article-title":"Inhibition of T lymphocyte activation by cAMP is associated with down-regulation of two paralell mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-JUN N-terminal kinase","volume":"157","author":"Tamir","year":"1996","journal-title":"J. Immunol."},{"key":"10.1006\/brbi.2001.0632_RF44","doi-asserted-by":"crossref","first-page":"112","DOI":"10.4049\/jimmunol.115.1.112","article-title":"Specific mitogenic activity of 8-Br-guanosine 3\u20325\u2032-monophosphate (Br-cyclic GMP) on B lymphocytes","volume":"115","author":"Weinstein","year":"1975","journal-title":"J. Immunol."},{"key":"10.1006\/brbi.2001.0632_RF45","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1365-2680.1997.00458.x","article-title":"Chronic terbutaline treatment desensitizes beta-adrenergic inhibition of lymphocyte activation in healthy volunteers","volume":"17","author":"Werner","year":"1997","journal-title":"J. Auton. Pharmacol."},{"key":"10.1006\/brbi.2001.0632_RF46","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliabillity and utility of the chronic mild stress model of depression","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1006\/brbi.2001.0632_RF47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0149-7634(05)80194-0","article-title":"Chronic mild stress-induced anhedonia: A realistic animal model of depression","volume":"16","author":"Willner","year":"1992","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1006\/brbi.2001.0632_RF48","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1073\/pnas.71.5.1725","article-title":"Muscarinic cholinergic binding in rat brain","volume":"71","author":"Yamamura","year":"1974","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/brbi.2001.0632_RF49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/sj.npp.1380235","article-title":"Role of tegmental cholinergic neurons in dopaminergic activation, antimuscarinic psychosis and schizophrenia","volume":"12","author":"Yloman","year":"1995","journal-title":"Neuropsychopharmacology"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159101906324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159101906324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:13:49Z","timestamp":1760166829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159101906324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,8]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,8]]}},"alternative-id":["S0889159101906324"],"URL":"https:\/\/doi.org\/10.1006\/brbi.2001.0632","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2002,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered Expression of Autonomic Neurotransmitter Receptors and Proliferative Responses in Lymphocytes from a Chronic Mild Stress Model of Depression: Effects of Fluoxetine","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/brbi.2001.0632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Elsevier Science (USA). All rights reserved.","name":"copyright","label":"Copyright"}]}}