{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T03:13:26Z","timestamp":1771038806682,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,2]],"date-time":"2013-01-02T00:00:00Z","timestamp":1357084800000},"content-version":"vor","delay-in-days":5449,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cell Biology International"],"published-print":{"date-parts":[[1998,2]]},"abstract":"<jats:p>Tropical spastic paraparesis\/HTLV\u2010I associated myelopathy (TSP\/HAM), is characterized by infiltration of human T cell leukaemia virus type\u2010I (HTLV\u2010I)\u2010infected T\u2010cells, anti\u2010HTLV\u2010I cytotoxic T cells and macrophages into the patients\u2019 cerebrospinal fluid and by intrathecally formed anti\u2010HTLV\u2010I antibodies. This implies that the disease involves a breakdown of the blood\u2014brain barrier. Since astrocytes play a central role in establishing this barrier, the authors investigated the hypothesis that the HTLV\u2010I infected T cells disrupt this barrier by damaging the astrocytes. The present study revealed the HTLV\u2010I\u2010producing T cells conferred a severe cytopatic effect upon monolayers of astrocytoma cell line in co\u2010cultures. Following co\u2010cultivation, HTLV\u2010I DNA and proteins appeared in the monolayer cells, but after reaching a peak their level gradually declined. This appearance of the viral components was proved to result from a fusion of the astrocytic cells with the virus\u2010producing T cells, whereas their subsequent decline reflected the destruction of the resulting syncytia. This fusion could be specifically blocked by anti HTLV\u2010I Env antibodies, indicating that it was mediated by the viral Env proteins expressed on the surface of the virus\u2010producing cells. Similar fusion was observed between the HTLV\u2010I\u2010producing cells and certain other human nervous system cell lines. If such fusion of HTLV\u2010I\u2010infected T cells occurs also with astrocytes and other nervous system cells in TSP\/HAM patients, it may account, at least partially, for the blood\u2014brain barrier breakdown and some of the neural lesions in this syndrome.<\/jats:p>","DOI":"10.1006\/cbir.1998.0241","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T14:51:08Z","timestamp":1032187868000},"page":"95-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["RAPID SYNCYTIUM FORMATION BETWEEN HUMAN T\u2010CELL LEUKAEMIA VIRUS TYPE\u2010I (HTLV\u2010I)\u2010INFECTED T\u2010CELLS AND HUMAN NERVOUS SYSTEM CELLS: A POSSIBLE IMPLICATION FOR TROPICAL SPASTIC PARAPARESIS\/HTLV\u2010I ASSOCIATED MYELOPATHY"],"prefix":"10.1002","volume":"22","author":[{"given":"NIRIT","family":"MOR\u2010VAKNIN","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"HAVA","family":"TURGEMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AMRAM","family":"TORGEMAN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARINA","family":"WOLFSON","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MAHMOUD","family":"HULEIHEL","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MORDECHAI","family":"ABOUD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,1,2]]},"container-title":["Cell Biology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1006%2Fcbir.1998.0241","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1006\/cbir.1998.0241","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T03:14:28Z","timestamp":1698462868000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1006\/cbir.1998.0241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,2]]}},"alternative-id":["10.1006\/cbir.1998.0241"],"URL":"https:\/\/doi.org\/10.1006\/cbir.1998.0241","archive":["Portico"],"relation":{},"ISSN":["1065-6995","1095-8355"],"issn-type":[{"value":"1065-6995","type":"print"},{"value":"1095-8355","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,2]]},"assertion":[{"value":"2013-01-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}