{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:24:30Z","timestamp":1760203470855,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cellular Immunology"],"published-print":{"date-parts":[[2001,11]]},"DOI":"10.1006\/cimm.2001.1880","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T14:32:46Z","timestamp":1033914766000},"page":"72-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Nitric Oxide Protects Thymocytes from \u03b3-Irradiation-Induced Apoptosis in Correlation with Inhibition of p53 Upregulation and Mitochondrial Damage"],"prefix":"10.1006","volume":"214","author":[{"given":"Yue","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ala","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Simmons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri R.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemary A.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/cimm.2001.1880_RF1","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/jnci\/92.13.1042","article-title":"Mitochondrion as a novel target of anticancer chemotherapy","volume":"92","author":"Costantini","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1006\/cimm.2001.1880_RF2","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/35037710","article-title":"The biochemistry of apoptosis","volume":"407","author":"Hengartner","year":"2000","journal-title":"Nature"},{"key":"10.1006\/cimm.2001.1880_RF3","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1023\/A:1020594531159","article-title":"Thymocyte apoptosis","volume":"19","author":"Yang","year":"1999","journal-title":"J. Clin. Immunol."},{"key":"10.1006\/cimm.2001.1880_RF4","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/095530099140168","article-title":"Review: Initiation of ionizing radiation-induced apoptosis","volume":"75","author":"Radford","year":"1999","journal-title":"Int. J. Radiation Biol."},{"key":"10.1006\/cimm.2001.1880_RF5","doi-asserted-by":"crossref","first-page":"S102","DOI":"10.2307\/3579812","article-title":"Radiation-induced signal transduction and stress response","volume":"150","author":"Haimovitz-Friedman","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1006\/cimm.2001.1880_RF6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1046\/j.1440-1711.1999.00824.x","article-title":"Molecular mechanisms of ionizing radiation-induced apoptosis","volume":"77","author":"Watters","year":"1999","journal-title":"Immunol. Cell. Biol."},{"key":"10.1006\/cimm.2001.1880_RF7","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/35037717","article-title":"Defying death after DNA damage","volume":"407","author":"Rich","year":"2000","journal-title":"Nature"},{"key":"10.1006\/cimm.2001.1880_RF8","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/370220a0","article-title":"p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes","volume":"370","author":"Caelles","year":"1994","journal-title":"Nature"},{"key":"10.1006\/cimm.2001.1880_RF9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/0092-8674(94)90268-2","article-title":"Nitric oxide synthase: Aspects concerning structure and catalysis","volume":"78","author":"Marletta","year":"1994","journal-title":"Cell"},{"key":"10.1006\/cimm.2001.1880_RF10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1159\/000159039","article-title":"The nitric oxide synthase family of proteins","volume":"31","author":"Sessa","year":"1994","journal-title":"J. Vasc. Res."},{"key":"10.1006\/cimm.2001.1880_RF11","doi-asserted-by":"crossref","first-page":"4110","DOI":"10.4049\/jimmunol.152.8.4110","article-title":"Inactivation of nitric oxide synthase after prolonged incubation with IFN-\u03b3 and bacterial lipopolysaccharide","volume":"152","author":"Vodovotz","year":"1994","journal-title":"J. Immunol."},{"key":"10.1006\/cimm.2001.1880_RF12","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1161\/01.RES.84.3.253","article-title":"Nitric oxide as a bifunctional regulator of apoptosis (mini review)","volume":"84","author":"Kim","year":"1999","journal-title":"Circ. Res."},{"key":"10.1006\/cimm.2001.1880_RF13","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.4049\/jimmunol.165.3.1252","article-title":"Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism","volume":"165","author":"Zhou","year":"2000","journal-title":"J. Immunol"},{"key":"10.1006\/cimm.2001.1880_RF14","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1006\/bbrc.1997.7672","article-title":"Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation","volume":"240","author":"Li","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/cimm.2001.1880_RF15","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1074\/jbc.272.2.1402","article-title":"Nitric oxide protects cultured rat hepatocytes from TNF\u03b1-induced apoptosis by inducing heat shock protein 70 expression","volume":"272","author":"Kim","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/cimm.2001.1880_RF16","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1074\/jbc.275.15.10954","article-title":"Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and casapse inhibition","volume":"275","author":"Kim","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/cimm.2001.1880_RF17","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.4049\/jimmunol.164.9.4649","article-title":"Thymic dendritic cells express inducible nitric oxide synthase and generate nitric oxide in response to self- and alloantigens","volume":"164","author":"Aiello","year":"2000","journal-title":"J. Immunol."},{"key":"10.1006\/cimm.2001.1880_RF18","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.4049\/jimmunol.155.6.2858","article-title":"Nitric oxide induces apoptosis in mouse thymocytes","volume":"155","author":"Fehsel","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/cimm.2001.1880_RF19","series-title":"Medical Radiation Biology","article-title":"Matter and energy exchange by ionizing radiations","author":"Pizzarello","year":"1982"},{"key":"10.1006\/cimm.2001.1880_RF20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2307\/3579905","article-title":"Radiation-induced apoptosis in human lymphocytes and lymphoma cells critically relies on the up-regulation of CD95\/Fas\/APO-1 ligand","volume":"149","author":"Belka","year":"1998","journal-title":"Radiat. Res."},{"key":"10.1006\/cimm.2001.1880_RF21","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.94.11.5750","article-title":"Radiation and stress-induced apoptosis: A role for Fas\/Fas ligand interactions","volume":"94","author":"Reap","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/cimm.2001.1880_RF22","doi-asserted-by":"crossref","first-page":"6130","DOI":"10.1074\/jbc.274.10.6130","article-title":"Nitric oxide fully protects against UVA-induced apoptosis in tight correlation with Bcl-2 up-regulation","volume":"274","author":"Suschek","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/cimm.2001.1880_RF23","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/(SICI)1097-4695(199912)41:4<549::AID-NEU10>3.0.CO;2-G","article-title":"Role of caspases in ionizing radiation-induced apoptosis in the developing cerebellum","volume":"41","author":"Ferrer","year":"1999","journal-title":"J. Neurobiol."},{"key":"10.1006\/cimm.2001.1880_RF24","doi-asserted-by":"crossref","first-page":"17325","DOI":"10.1074\/jbc.274.24.17325","article-title":"Nitric oxide suppresses apoptosis via interrupting caspase activation and mitochondrial dysfunction in cultured hepatocytes","volume":"274","author":"Li","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/cimm.2001.1880_RF25","doi-asserted-by":"crossref","first-page":"31138","DOI":"10.1074\/jbc.272.49.31138","article-title":"Nitric oxide inhibits apoptosis by preventing increases in caspase-3-like activity via two distinct mechanisms","volume":"272","author":"Kim","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1006\/cimm.2001.1880_RF26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(94)01161-3","article-title":"p53 Expression in nitric-oxide induced apoptosis","volume":"355","author":"Messmer","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1006\/cimm.2001.1880_RF27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"key":"10.1006\/cimm.2001.1880_RF28","doi-asserted-by":"crossref","first-page":"8823","DOI":"10.1073\/pnas.95.15.8823","article-title":"Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice","volume":"95","author":"Ambs","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/cimm.2001.1880_RF29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/362847a0","article-title":"p53 is required for radiation-induced apoptosis in mouse thymocytes","volume":"362","author":"Lowe","year":"1993","journal-title":"Nature"},{"key":"10.1006\/cimm.2001.1880_RF30","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0092-8674(00)81476-2","article-title":"Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9","volume":"94","author":"Kuida","year":"1998","journal-title":"Cell"},{"key":"10.1006\/cimm.2001.1880_RF31","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0092-8674(00)81477-4","article-title":"Differential requirement for caspase 9 in apoptotic pathways in vivo","volume":"94","author":"Hakem","year":"1998","journal-title":"Cell"},{"key":"10.1006\/cimm.2001.1880_RF32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1189\/jlb.70.1.87","article-title":"Nitric oxide induces murine thymocyte apoptosis by oxidative injury and a p53-dependent mechanism","volume":"70","author":"Gordon","year":"2001","journal-title":"J. Leukocyte Biol."},{"key":"10.1006\/cimm.2001.1880_RF33","doi-asserted-by":"crossref","first-page":"16202","DOI":"10.1074\/jbc.275.21.16202","article-title":"Death signal-induce localization of p53 protein to mitochondria","volume":"275","author":"Marchenko","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/cimm.2001.1880_RF34","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1006\/bbrc.2001.4670","article-title":"Nitric oxide as a bioregulator of apoptosis","volume":"282","author":"Chung","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/cimm.2001.1880_RF35","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1038\/sj.onc.1204575","article-title":"The adenine nucleotide translocator: A target of nitric oxide, peroxynitrite, and 4-hydroxynonenal","volume":"20","author":"Vieira","year":"2001","journal-title":"Oncogene"},{"key":"10.1006\/cimm.2001.1880_RF36","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1006\/bbrc.2001.4423","article-title":"Nitric oxide prevents \u03b3-radiation-induced cell cycle arrest by impairing p53 function in MCF-7 cells","volume":"281","author":"Chazotte-Aubert","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Cellular Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874901918805?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0008874901918805?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T22:31:01Z","timestamp":1757802661000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0008874901918805"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,11]]}},"alternative-id":["S0008874901918805"],"URL":"https:\/\/doi.org\/10.1006\/cimm.2001.1880","relation":{},"ISSN":["0008-8749"],"issn-type":[{"type":"print","value":"0008-8749"}],"subject":[],"published":{"date-parts":[[2001,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitric Oxide Protects Thymocytes from \u03b3-Irradiation-Induced Apoptosis in Correlation with Inhibition of p53 Upregulation and Mitochondrial Damage","name":"articletitle","label":"Article Title"},{"value":"Cellular Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/cimm.2001.1880","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2001 Elsevier Science (USA). All rights reserved.","name":"copyright","label":"Copyright"}]}}