{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T06:46:11Z","timestamp":1789368371830,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,9,1]],"date-time":"1999-09-01T00:00:00Z","timestamp":936144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[1999,9]]},"DOI":"10.1006\/clim.1999.4760","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:13:49Z","timestamp":1033931629000},"page":"293-299","source":"Crossref","is-referenced-by-count":49,"title":["The Development of AIDS-Associated Burkitt's\/Small Noncleaved Cell Lymphoma Is Preceded by Elevated Serum Levels of Interleukin 6"],"prefix":"10.1006","volume":"92","author":[{"given":"Elizabeth","family":"Crabb Breen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meta","family":"van der Meijden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Cumberland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Detels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otoniel","family":"Mart\u0131\u0301nez-Maza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/clim.1999.4760_RF1","first-page":"67","article-title":"Molecular pathology of acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma","volume":"14","author":"Knowles","year":"1997","journal-title":"Semin. Diag. Pathol."},{"key":"10.1006\/clim.1999.4760_RF2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1182\/blood.V81.1.166.bloodjournal811166","article-title":"Multiple genetic lesions in acquired immunodeficiency syndrome-related non-Hodgkin's lymphoma","volume":"81","author":"Ballerini","year":"1993","journal-title":"Blood"},{"key":"10.1006\/clim.1999.4760_RF3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/annonc\/8.suppl_2.S105","article-title":"Involvement of the bcl-6 gene in AIDS-related lymphomas","volume":"8","author":"Gaidano","year":"1997","journal-title":"Ann. Oncol."},{"key":"10.1006\/clim.1999.4760_RF4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/0140-6736(91)91837-K","article-title":"EBV in AIDS-related primary central nervous system lymphoma","volume":"338","author":"MacMahon","year":"1991","journal-title":"Lancet"},{"key":"10.1006\/clim.1999.4760_RF5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/oxfordjournals.aje.a116691","article-title":"Trends in the incidence of outcomes defining acquired immunodeficiency syndrome (AIDS) in the Multicenter AIDS Cohort Study: 1985\u20131991","volume":"137","author":"Mu\u00f1oz","year":"1993","journal-title":"Am. J. Epidemiol."},{"key":"10.1006\/clim.1999.4760_RF6","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.iy.13.040195.002415","article-title":"New concepts in the immunopathogenesis of HIV infection","volume":"113","author":"Pantaleo","year":"1995","journal-title":"Annu. Rev. Immunol."},{"key":"10.1006\/clim.1999.4760_RF7","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1056\/NEJM198308253090803","article-title":"Abnormalities of B-cell activation and immunoregulation in patients with AIDS","volume":"309","author":"Lane","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/clim.1999.4760_RF8","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.4049\/jimmunol.138.11.3720","article-title":"Infection with HIV is associated with an in vivo increase in B lymphocyte activation and immaturity","volume":"138","author":"Mart\u0131&#x0301;nez-Maza","year":"1987","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF9","first-page":"410","article-title":"B cell activation in HIV infection: Relationship of spontaneous immunoglobulin secretion to various immunologic parameters","volume":"71","author":"Mizuma","year":"1988","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/clim.1999.4760_RF10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gcc.2870010103","article-title":"Multiple phenotypic consequences of the Ig\/Myc translocation in B-cell-derived tumors","volume":"1","author":"Klein","year":"1989","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1006\/clim.1999.4760_RF11","first-page":"5522s","article-title":"Pathogenetic mechanisms in B-cell non-Hodgkin's lymphomas","volume":"52","author":"Potter","year":"1992","journal-title":"Cancer Res."},{"key":"10.1006\/clim.1999.4760_RF12","first-page":"5529s","article-title":"Molecular basis of lymphomagenesis","volume":"52","author":"Magrath","year":"1992","journal-title":"Cancer Res."},{"key":"10.1006\/clim.1999.4760_RF13","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1182\/blood.V85.7.1843.bloodjournal8571843","article-title":"Elevated serum levels of soluble CD23 (sCD23) precede the appearance of AIDS-associated non-Hodgkin's lymphoma","volume":"85","author":"Yawetz","year":"1995","journal-title":"Blood"},{"key":"10.1006\/clim.1999.4760_RF14","unstructured":"Miedzinski, L, Jewell, L, Parfrey, N, Poppema, S, Preiksaitis, J, and, Larrat, L, EBV-related lymphoproliferation in AIDS, IX International Conference on AIDS, PO-B13-1619, 1993. [Abstract]"},{"key":"10.1006\/clim.1999.4760_RF15","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1002\/j.1460-2075.1987.tb02412.x","article-title":"The activation antigen BLAST-2, when shed, is an autocrine BCGF for normal and transformed B cells","volume":"6","author":"Swendeman","year":"1987","journal-title":"EMBO J."},{"key":"10.1006\/clim.1999.4760_RF16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0167-5699(89)90171-0","article-title":"CD23: A multi-functional receptor\/lymphokine","volume":"10","author":"Gordon","year":"1989","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.1999.4760_RF17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0167-5699(90)90173-7","article-title":"Biological and clinical aspects of IL6","volume":"11","author":"Hirano","year":"1990","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.1999.4760_RF18","doi-asserted-by":"crossref","first-page":"480","DOI":"10.4049\/jimmunol.144.2.480","article-title":"Infection with HIV is associated with elevated IL6 levels and production","volume":"144","author":"Breen","year":"1990","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF19","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1182\/blood.V76.11.2303.2303","article-title":"Induction of interleukin-6 during human immunodeficiency virus infection","volume":"76","author":"Birx","year":"1990","journal-title":"Blood"},{"key":"10.1006\/clim.1999.4760_RF20","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.4049\/jimmunol.145.12.4059","article-title":"Quantitative analysis of serum IL6 and its correlation with increased levels of serum IL2R in HIV-induced diseases","volume":"145","author":"Honda","year":"1990","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF21","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/00002030-199109000-00014","article-title":"Increased IL6 production is associated with disease progression in HIV infection","volume":"5","author":"Lafeuillade","year":"1991","journal-title":"AIDS"},{"key":"10.1006\/clim.1999.4760_RF22","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/aje\/126.2.310","article-title":"The multicenter AIDS cohort study: Rationale, organization and selected characteristics of the participants","volume":"126","author":"Kaslow","year":"1987","journal-title":"Am. J. Epidemiol."},{"key":"10.1006\/clim.1999.4760_RF23","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.2188\/jea.2.2sup_11","article-title":"Recent scientific contributions to understanding HIV\/AIDS from the Multicenter AIDS Cohort Study","volume":"2","author":"Detels","year":"1992","journal-title":"J. Epidemiol. (Jpn)"},{"key":"10.1006\/clim.1999.4760_RF24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/aid.1997.13.781","article-title":"Interleukin 6 and AIDS-associated Kaposi's sarcoma: A nested case control study within the Multicenter AIDS Cohort Study","volume":"13","author":"Dourado","year":"1997","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1006\/clim.1999.4760_RF25","first-page":"A39","article-title":"for the Multicenter AIDS Cohort Study, Impact of highly effective anti-retroviral therapy on the incidence of malignancies among HIV-infected individuals","volume":"17","author":"Jacobson","year":"1998","journal-title":"J. AIDS Hum. Retrovirol."},{"key":"10.1006\/clim.1999.4760_RF26","first-page":"285a","article-title":"Factors which predict for the development of non-Hodgkin's lymphomas (NHL) in patients with HIV infection receiving antiretroviral therapy","volume":"78","author":"Pluda","year":"1991","journal-title":"Blood"},{"key":"10.1006\/clim.1999.4760_RF27","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1200\/JCO.1993.11.6.1099","article-title":"Parameters affecting the development of non-Hodgkin's lymphoma in patients with severe human immunodeficiency virus infection receiving antiretroviral therapy","volume":"11","author":"Pluda","year":"1993","journal-title":"J. Clin. Oncol."},{"key":"10.1006\/clim.1999.4760_RF28","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1002\/(SICI)1097-0142(19960801)78:3<517::AID-CNCR20>3.0.CO;2-0","article-title":"Low dose methotrexate, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone with zalcitabine in patients with acquired immunodeficiency syndrome-related lymphoma","volume":"78","author":"Levine","year":"1996","journal-title":"Cancer"},{"key":"10.1006\/clim.1999.4760_RF29","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1182\/blood.V80.2.498.498","article-title":"IL-6 production in high-grade B lymphomas: Correlation with the presence of malignant immunoblasts in acquired immunodeficiency syndrome and in human immunodeficiency virus-seronegative patients","volume":"80","author":"Emilie","year":"1992","journal-title":"Blood"},{"key":"10.1006\/clim.1999.4760_RF30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1600-0609.1996.tb01390.x","article-title":"Clinical implications of serum levels of soluble CD23 and tumor necrosis factor alpha in low-grade non-Hodgkin's lymphoma","volume":"57","author":"Zinzani","year":"1996","journal-title":"Eur. J. Haematol."},{"key":"10.1006\/clim.1999.4760_RF31","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.4049\/jimmunol.154.6.2533","article-title":"Endogenous IL-6 and IL-10 contribute to the differentiation of CD40-activated human B lymphocytes","volume":"154","author":"Burdin","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF32","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1073\/pnas.89.1.232","article-title":"Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice","volume":"89","author":"Suematsu","year":"1992","journal-title":"PNAS"},{"key":"10.1006\/clim.1999.4760_RF33","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/eji.1830240823","article-title":"Soluble CD23 potentiates interleukin-1-induced secretion of interleukin-6 and interleukin-1 receptor antagonist by human monocytes","volume":"24","author":"Herbelin","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF34","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/1074-7613(95)90164-7","article-title":"CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18","volume":"3","author":"Lecoanet-Henchoz","year":"1995","journal-title":"Immunity"},{"key":"10.1006\/clim.1999.4760_RF35","first-page":"228","article-title":"Germ-line human epsilon heavy chain gene RNA transcripts utilize the full range of alternative 3\u2032 splicing seen in productive epsilon mRNA","volume":"85","author":"Zhang","year":"1995","journal-title":"Immunology"},{"key":"10.1006\/clim.1999.4760_RF36","doi-asserted-by":"crossref","first-page":"3427","DOI":"10.4049\/jimmunol.152.7.3427","article-title":"Switch circles from IL-4-directed \u03f5 class switching from human B lymphocytes","volume":"152","author":"Zhang","year":"1994","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF37","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.4049\/jimmunol.155.5.2318","article-title":"IL-4 plus CD40 monoclonal antibody induces human B cells \u03b3 subclass-specific isotype switch","volume":"155","author":"Fujieda","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4760_RF38","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1126\/science.7997879","article-title":"Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma","volume":"266","author":"Chang","year":"1994","journal-title":"Science"},{"key":"10.1006\/clim.1999.4760_RF39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nm0396-342","article-title":"Lytic growth of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in culture","volume":"2","author":"Renne","year":"1996","journal-title":"Nature Med."},{"key":"10.1006\/clim.1999.4760_RF40","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1182\/blood.V91.6.1858","article-title":"Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells","volume":"91","author":"Burger","year":"1998","journal-title":"Blood"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661699947605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661699947605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T16:22:18Z","timestamp":1680625338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661699947605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,9]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,9]]}},"alternative-id":["S1521661699947605"],"URL":"https:\/\/doi.org\/10.1006\/clim.1999.4760","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[1999,9]]}}}