{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:24:42Z","timestamp":1761560682022},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1999,12,1]],"date-time":"1999-12-01T00:00:00Z","timestamp":944006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[1999,12]]},"DOI":"10.1006\/clim.1999.4792","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:13:49Z","timestamp":1033931629000},"page":"274-282","source":"Crossref","is-referenced-by-count":20,"title":["Immune Complex Size and Complement Regulate Cytokine Production by Peripheral Blood Mononuclear Cells"],"prefix":"10.1006","volume":"93","author":[{"given":"James N.","family":"Jarvis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChengSu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard R.","family":"Petty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melba","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nemat","family":"Morssy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Waxman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Quintero del Rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/clim.1999.4792_RF1","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1365-2249.1995.tb03731.x","article-title":"Composition and biological behaviour of immune complexes isolated from synovial fluids of patients with juvenile rheumatoid arthritis (JRA)","volume":"100","author":"Jarvis","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/clim.1999.4792_RF2","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/art.1780401117","article-title":"In vitro induction of proinflammatory cytokine secretion by juvenile rheumatoid arthritis synovial fluid immune complexes","volume":"40","author":"Jarvis","year":"1997","journal-title":"Arthritis Rheum."},{"key":"10.1006\/clim.1999.4792_RF3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1006\/cimm.1999.1481","article-title":"Complement deposition on immune complexes reduces the frequencies of metabolic, proteolytic, and superoxide oscillations in migrating neutrophils","volume":"194","author":"Amit","year":"1999","journal-title":"Cell. Immunol."},{"key":"10.1006\/clim.1999.4792_RF4","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.4049\/jimmunol.153.4.1430","article-title":"Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation","volume":"153","author":"Chen","year":"1994","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4792_RF5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1615\/CritRevImmunol.v15.i2.10","article-title":"Complement receptors on neutrophils","volume":"15","author":"Sengel\u00f8v","year":"1995","journal-title":"Crit. Rev. Immunol."},{"key":"10.1006\/clim.1999.4792_RF6","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0167-5699(91)90011-H","article-title":"The role of C3 in the immune response","volume":"9","author":"Erdei","year":"1991","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.1999.4792_RF7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0008-8749(92)90277-V","article-title":"Distribution and quantitative expression of the complement receptor type 1 (CR1) on human peripheral blood T lymphocytes","volume":"142","author":"Yaskanin","year":"1992","journal-title":"Cell. Immunol."},{"key":"10.1006\/clim.1999.4792_RF8","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0008-8749(90)90137-G","article-title":"Regulation of human autologous T cell proliferation by endogenously generated C5a","volume":"127","author":"Montz","year":"1990","journal-title":"Cell. Immunol."},{"key":"10.1006\/clim.1999.4792_RF9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1084\/jem.173.1.55","article-title":"Intersection of the complement and immune systems: A signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19","volume":"173","author":"Matsumoto","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1006\/clim.1999.4792_RF10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.4049\/jimmunol.151.1.330","article-title":"Signaling properties of CR3 (CD11b\/18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles","volume":"151","author":"F\u00e4llman","year":"1993","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4792_RF11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0167-5699(96)30013-3","article-title":"Integrins as signal transduction devices","volume":"17","author":"Petty","year":"1996","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.1999.4792_RF12","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1159\/000467837","article-title":"Study of complement effects on the kinetics of immune precipitation","volume":"1","author":"Miletic","year":"1984","journal-title":"Complement"},{"key":"10.1006\/clim.1999.4792_RF13","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000463045","article-title":"C4-mediated inhibition of immune precipitation and differences in inhibitory action of genetic variants C4A3 and C4B1","volume":"5","author":"Paul","year":"1988","journal-title":"Complement"},{"key":"10.1006\/clim.1999.4792_RF14","first-page":"135","article-title":"IgM rheumatoid factor and the inhibition of covalent binding of C4b to IgG in immune complexes","volume":"11","author":"Jarvis","year":"1993","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1006\/clim.1999.4792_RF15","first-page":"407","article-title":"Complement-mediated inhibition of immune precipitation and solubilization generate different concentration anaphylactoins","volume":"64","author":"Schifferli","year":"1986","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/clim.1999.4792_RF16","first-page":"1124","article-title":"Complement activation and immune complexes in children with polyarticular JRA: A longitudinal study","volume":"21","author":"Jarvis","year":"1994","journal-title":"J. Rheumatol."},{"key":"10.1006\/clim.1999.4792_RF17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000229699","article-title":"A method for trace iodination of proteins for immunological studies","volume":"29","author":"McConahey","year":"1966","journal-title":"Int. Arch. All. Appl. Immunol."},{"key":"10.1006\/clim.1999.4792_RF18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0022-1759(76)90174-5","article-title":"A simple numerical method for the construction of isokinetic sucrose density gradients, and their application to the characterization of immunoglobulin complexes","volume":"10","author":"Johns","year":"1976","journal-title":"J. Appl. Immunol. Methods"},{"key":"10.1006\/clim.1999.4792_RF19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0003-2697(81)90703-X","article-title":"Iodination of proteins, glycoproteins, and peptides using a solid phase oxidating agent, 1,3,4,6-tetrachlo-3-\u03b1-6-\u03b1phenylglycuryl (Iodogen)","volume":"117","author":"Salacinski","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1006\/clim.1999.4792_RF20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00270246","article-title":"C3-containing serum immune complexes in patients with systemic lupus erythematosus: Correlation to disease activity and comparison with other rheumatic diseases","volume":"9","author":"Huber","year":"1989","journal-title":"Rheumatol. Int."},{"key":"10.1006\/clim.1999.4792_RF21","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1097\/00042560-199504120-00008","article-title":"Complement activation and immune complexes in early congenital HIV infection","volume":"8","author":"Jarvis","year":"1995","journal-title":"J. Acq. Immune Def. Syndr. Retrovirol."},{"key":"10.1006\/clim.1999.4792_RF22","first-page":"375","article-title":"Binding and catabolism of aggregated immunoglobulins bearing C3b or iC3b by U937 cells","volume":"64","author":"Daha","year":"1988","journal-title":"Immunology"},{"key":"10.1006\/clim.1999.4792_RF23","doi-asserted-by":"crossref","unstructured":"Schifferli, J., Ng, Y., and Peters, K., The role of complement and receptors in the elimination of immune complexes. N. Engl. J. Med.315, 488\u2013495.","DOI":"10.1056\/NEJM198608213150805"},{"key":"10.1006\/clim.1999.4792_RF24","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4049\/jimmunol.144.1.147","article-title":"Induction of IL-1 release through stimulation of the C3b\/C4b complement receptor type 1 (CR1, CD35) on human monocytes","volume":"144","author":"Bacle","year":"1990","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4792_RF25","doi-asserted-by":"crossref","first-page":"4861","DOI":"10.4049\/jimmunol.155.10.4861","article-title":"Triggering of complement receptor CR1 (CD35) and CR3 (CD11b\/CD18) induces nuclear translocation of NF-\u03baB (p50\/p65) in human monocytes and induces viral replication in HIV-infected cells","volume":"155","author":"Thieblemont","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4792_RF26","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jlb.63.4.477","article-title":"Ligation of CR1 attenuates Fc receptor-mediated myeloperoxidase release and HOCl production by neutrophils","volume":"63","author":"Sambandam","year":"1998","journal-title":"J. Leukocyte Biol."},{"key":"10.1006\/clim.1999.4792_RF27","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.4049\/jimmunol.150.7.3030","article-title":"Cocapping of leukoadhesin molecules complement receptor type 3 and lymphocyte function-associated antigen-1 with Fc\u03b3 receptor III on human neutrophils","volume":"150","author":"Zhou","year":"1993","journal-title":"J. Immunol."},{"key":"10.1006\/clim.1999.4792_RF28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/eji.1830260132","article-title":"The \u03b22 integrin Mac-1 but not p150,95 associates with Fc\u03b3IIA","volume":"26","author":"Annenkov","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/clim.1999.4792_RF29","first-page":"S127","article-title":"Regulation of monocytes through complement receptor CR1: Binding of C4b to immune complexes enhances IL-1\u03b2 secretion","volume":"40","author":"Jarvis","year":"1997","journal-title":"Arthritis Rheum."}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661699947927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661699947927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T16:22:11Z","timestamp":1680625331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661699947927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,12]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1999,12]]}},"alternative-id":["S1521661699947927"],"URL":"https:\/\/doi.org\/10.1006\/clim.1999.4792","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[1999,12]]}}}