{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T06:52:03Z","timestamp":1768027923128,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Immunology"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1006\/clim.2001.5081","type":"journal-article","created":{"date-parts":[[2002,9,16]],"date-time":"2002-09-16T15:45:11Z","timestamp":1032191111000},"page":"305-313","source":"Crossref","is-referenced-by-count":34,"title":["Preeclampsia, a Pregnancy-Specific Disease, Is Associated with Fetal Monocyte Activation"],"prefix":"10.1006","volume":"100","author":[{"given":"A.","family":"Steinborn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Sayehli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Niederhut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/clim.2001.5081_RF1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0167-5699(93)90235-D","article-title":"Bidirectional cytokine interactions in the maternal fetal relationship: Is successfull pregnancy a Th2 phenomenon?","volume":"14","author":"Wegmann","year":"1993","journal-title":"Immunol Today"},{"key":"10.1006\/clim.2001.5081_RF2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1006\/clim.2001.5081_RF3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0167-5699(96)80606-2","article-title":"The expanding universe of T-cell subsets: Th1, Th2 and more","volume":"17","author":"Mosmann","year":"1996","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.2001.5081_RF4","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S0167-5699(97)01127-4","article-title":"Th1-type immunity is incompatible with successful pregnancy","volume":"18","author":"Raghupathy","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.2001.5081_RF5","first-page":"103","article-title":"Comparative cytokine production by in vitro stimulated mononucleated cells from cord blood and adult blood","volume":"25","author":"Sautois","year":"1997","journal-title":"Exp. Hematol."},{"key":"10.1006\/clim.2001.5081_RF6","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.4049\/jimmunol.160.9.4217","article-title":"Newborn mice develop balanced Th1\/Th2 primary effector response in vivo but biased to Th2 secondary response","volume":"160","author":"Adkins","year":"1998","journal-title":"J. Immunol."},{"key":"10.1006\/clim.2001.5081_RF7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/0029-7844(96)00224-4","article-title":"Elevated placental cytokine release, a process associated with preterm labor in the absence of intrauterine infection","volume":"88","author":"Steinborn","year":"1996","journal-title":"Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0029-7844(97)00680-7","article-title":"Identification of placental cytokine producing cells in term and preterm labor","volume":"91","author":"Steinborn","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF9","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1006\/cyto.1998.0399","article-title":"Cytokine release from placental endothelial cells, a process associated with preterm labor in the absence of intrauterine infection","volume":"11","author":"Steinborn","year":"1999","journal-title":"Cytokine"},{"key":"10.1006\/clim.2001.5081_RF10","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0002-9378(95)91333-5","article-title":"Placental pathologic features of preterm preeclampsia","volume":"173","author":"Salafia","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF11","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0002-9378(93)90499-9","article-title":"Maternal placental vasculopathy and infection: Two distinct subgroups among patients with preterm labor and preterm ruptured membranes","volume":"168","author":"Arias","year":"1993","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00006254-199804000-00021","article-title":"Pathogenesis of preeclampsia: A comprehensive model","volume":"53","author":"van Beck","year":"1998","journal-title":"Obstet. Gynecol. Surv."},{"key":"10.1006\/clim.2001.5081_RF13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1203\/00006450-199704000-00015","article-title":"High level interleukin-12 production but diminished interferon-\u03b3 production by cord blood mononuclear cells","volume":"41","author":"Scott","year":"1997","journal-title":"Pediatr. Res."},{"key":"10.1006\/clim.2001.5081_RF14","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.4049\/jimmunol.155.10.4604","article-title":"Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-\u03b3 and IL-2 but not IL-4 and IL-5","volume":"155","author":"Katamura","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/clim.2001.5081_RF15","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1046\/j.1365-2249.1999.00938.x","article-title":"Spontaneous labor at term is associated with fetal monocyte activation","volume":"117","author":"Steinborn","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/clim.2001.5081_RF16","first-page":"177","article-title":"The role of the spiral arteries in the pathogenesis of preeclampsia","volume":"1","author":"Brosens","year":"1972","journal-title":"Obstet. Gynecol. Annu."},{"key":"10.1006\/clim.2001.5081_RF17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1055\/s-2007-1016248","article-title":"Endothelial dysfunction in preeclampsia","volume":"16","author":"Roberts","year":"1998","journal-title":"Semin. Reprod. Endocrinol."},{"key":"10.1006\/clim.2001.5081_RF18","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0002-9378(96)70045-5","article-title":"Evidence of endothelial activation and endothelial activators in cord blood of infants of preeclamptic women","volume":"175","author":"Davidge","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF19","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0002-9378(99)70239-5","article-title":"Preeclampsia: An excessive maternal inflammatory response to pregnancy","volume":"180","author":"Redman","year":"1999","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF20","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1042\/cs0920037","article-title":"Neutrophil CD11b expression and neutrophil activation in preeclampsia","volume":"92","author":"Barden","year":"1997","journal-title":"Clin. Sci."},{"key":"10.1006\/clim.2001.5081_RF21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/S0002-9378(98)70254-6","article-title":"Normal pregnancy and preeclampsia both produce inflammatory changes in peripheral blood leukocytes akin to those of sepsis","volume":"179","author":"Sacks","year":"1998","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1471-0528.1995.tb09020.x","article-title":"Interleukin-6, tumor necrosis factor and soluble tumor necrosis factor receptors in women with preeclampsia","volume":"102","author":"Vince","year":"1995","journal-title":"Br. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF23","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1600-0897.1998.tb00372.x","article-title":"Plasma interleukin-12 is elevated in patients with preeclampsia","volume":"39","author":"Daniel","year":"1998","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1006\/clim.2001.5081_RF24","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/S0041-1345(99)00181-5","article-title":"Detection of soluble HLA-G levels in maternal serum can be predictive for a successful pregnancy","volume":"31","author":"Athanassakis","year":"1999","journal-title":"Transplant. Proc."},{"key":"10.1006\/clim.2001.5081_RF25","first-page":"1582","article-title":"Hypoxia stimulates cytokine production by villous explants from human placenta","volume":"82","author":"Benyo","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/clim.2001.5081_RF26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1471-0528.1997.tb11052.x","article-title":"Human placental syncytiotrophoblast microvillous membranes impair maternal vascular endothelial function","volume":"104","author":"Cockell","year":"1997","journal-title":"Br. J. Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/plac.1998.0351","article-title":"Purification and characterization of a complex from placental syncytiotrophoblast microvillous membranes which inhibits the proliferation of human umbilical vein endothelial cells","volume":"20","author":"Kertesz","year":"1999","journal-title":"Placenta"},{"key":"10.1006\/clim.2001.5081_RF28","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1093\/humrep\/14.4.919","article-title":"Supernatants from co-cultured endothelial cells and syncytiotrophoblast microvillous membranes activate peripheral blood leukocytes in vitro","volume":"14","author":"von Dadelszen","year":"1999","journal-title":"Hum. Reprod."},{"key":"10.1006\/clim.2001.5081_RF29","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0029-7844(98)00068-4","article-title":"Disturbed feto-maternal cell traffic in preeclampsia","volume":"91","author":"Holzgreve","year":"1998","journal-title":"Obstet. Gynecol."},{"key":"10.1006\/clim.2001.5081_RF30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0167-5699(94)90020-5","article-title":"Is restricted antigen presentation the explanation for fetal allograft survival","volume":"15","author":"Wood","year":"1994","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.2001.5081_RF31","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1046\/j.1365-2249.1999.00997.x","article-title":"Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia","volume":"117","author":"Saito","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/clim.2001.5081_RF32","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.4049\/jimmunol.129.4.1479","article-title":"Detection of IgG bound within human trophoblast","volume":"129","author":"Wood","year":"1982","journal-title":"J. Immunol."},{"key":"10.1006\/clim.2001.5081_RF33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/00007890-197508000-00011","article-title":"Transfer of HLA antibodies from the mother to the child: Complement of information","volume":"20","author":"Tongio","year":"1975","journal-title":"Transplantation"},{"key":"10.1006\/clim.2001.5081_RF34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0008-8749(90)90189-X","article-title":"Aggregated immunoglobulin and Fc fragment of IgG induce IL-6 release from human monocytes","volume":"129","author":"Ling","year":"1990","journal-title":"Cell. Immunol."},{"key":"10.1006\/clim.2001.5081_RF35","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.4049\/jimmunol.145.5.1337","article-title":"Cross-linking Fc-receptors on monocytes triggers IL-6 production: Role in anti CD3 induced T cell activation","volume":"145","author":"Krutmann","year":"1990","journal-title":"J. Immunol."},{"key":"10.1006\/clim.2001.5081_RF36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0167-5699(98)01393-0","article-title":"An innate view of human pregnancy","volume":"20","author":"Sacks","year":"1999","journal-title":"Immunol. Today"},{"key":"10.1006\/clim.2001.5081_RF37","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/S0264-410X(98)00107-8","article-title":"Human placental Fc receptors and the trapping of immune complexes","volume":"16","author":"Simister","year":"1998","journal-title":"Vaccine"}],"container-title":["Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661601950818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1521661601950818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T00:33:20Z","timestamp":1680568400000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1521661601950818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S1521661601950818"],"URL":"https:\/\/doi.org\/10.1006\/clim.2001.5081","relation":{},"ISSN":["1521-6616"],"issn-type":[{"value":"1521-6616","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}